Improving Survival after Ischemic Stroke and Prevention of Recurrent Ischemic Stroke in African-Americans: Medical and Surgical Intervention

1998 ◽  
pp. 142-155
Author(s):  
G.H. Friday ◽  
E.S. Cooper ◽  
H.L. Mignott
Keyword(s):  
Ischemic Stroke ◽  
African Americans ◽  
Surgical Intervention

scholarly journals Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke

2015 ◽  
Vol 6 (6) ◽  
pp. 430-436 ◽  
Author(s):  
Candice M. Brown ◽  
Cheryl D. Bushnell ◽  
Gregory P. Samsa ◽  
Larry B. Goldstein ◽  
Carol A. Colton
Keyword(s):  
Ischemic Stroke ◽  
African Americans ◽  
Immune Dysfunction ◽  
Small Vessel

Abstract P104: Incidence, Characteristics and Outcomes of Large Vessel Stroke in Covid-19: An International Multicenter Study

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Priyank Khandelwal ◽  
Fawaz Al-Mufti ◽  
Ambooj Tiwari ◽  
Amit Singla ◽  
Adam A Dmytriw ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
African Americans ◽  
Acute Ischemic Stroke ◽  
Multicenter Study ◽  
Significant Risk ◽  
Large Vessel ◽  
Large Vessel Occlusion ◽  
Vessel Occlusion ◽  
International Multicenter Study ◽  
International Multicenter

Background: While there are reports of acute ischemic stroke (AIS) in COVID-19 patients, the overall incidence of acute ischemic stroke and clinical characteristics of large vessel occlusion in such patient remains to be established. Methods: A retrospective, international multicenter study of large vessel occlusion (LVO) was undertaken from March 1 to May 1, 2020 at 12 stroke centers from 4 countries. Detailed data were collected on consecutive LVOs in hospitalized patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the incidence of AIS/LVO was measured. Among patients who underwent mechanical thrombectomy, stroke outcomes along with COVID-19 symptoms were reported. Results: Out of a total of 6698 COVID-19 patients admitted to 10 stroke centers, the incidence of stroke was found to be 1.3% (range 0.6-2.6%). The median age of patients who presented with LVO was 51 years (range 27-87) and in the US centers, African Americans comprised 28% of all patients. Ten patients (16 %) were less than 50 years of age with no significant risk factors for LVOs the vast majority. Among the LVOs eligible for MT, the average time to presentation from symptom onset to presentation was 9.3 hours. Successful revascularization was achieved in 81% of patients and the intracranial hemorrhage rate was 14% with no symptomatic hemorrhages. Twenty-one (50%) patients were either discharged to home or to acute rehabilitation facilities. Conclusion: LVOs was predominant in patients with AIS and COVID-19, occurring at a significantly younger age and affecting African Americans disproportionately.

Abstract 3060: Racial Disparities in Early Institution of “Do Not Resuscitate” Orders Influence Survival in Acute Ischemic Strokes.

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Pratik Bhattacharya ◽  
Ambooj Tiwari ◽  
Sam Watson ◽  
Scott Millis ◽  
Seemant Chaturvedi ◽  
...  
Keyword(s):  
Critical Care ◽  
African American ◽  
Ischemic Stroke ◽  
African Americans ◽  
Acute Ischemic Stroke ◽  
Racial Differences ◽  
Racial Disparity ◽  
Retrospective Chart Review ◽  
Do Not Resuscitate ◽  
Dnr Orders

Background: The importance of early institution of “Do Not Resuscitate” (DNR) orders in determining outcomes from intracerebral hemorrhage is established. In the setting of acute ischemic stroke, African Americans tend to utilize critical care interventions more and palliative care options less than Caucasians. Recent epidemiological studies in acute ischemic stroke have shown a somewhat better survival for African Americans compared with Caucasians. Our hypothesis was that racial differences in early institution of DNR orders would influence mortality in acute ischemic stroke. Methods: a retrospective chart review was conducted on consecutive admissions for acute ischemic stroke across 10 hospitals in Michigan for the year 2006. Subjects with self reported race as African American or Caucasian were selected. Demographics, stroke risk factors, pre morbid status, DNR by day 2 of admission, stroke outcome and discharge destination were abstracted. Results: The study included 574 subjects (144 African American, 25.1%; 430 Caucasian, 74.9%). In-hospital mortality was significantly higher among Caucasians (8.6% vs. 1.4% amongst African Americans, p=0.003). More Caucasians had institution of DNR by day 2 than African Americans (22.5% vs. 4.3%, p<0.0001). When adjusted for racial differences in DNR by day 2 status, Caucasian race no longer predicted mortality. Caucasians were significantly older than African Americans (median age 76 vs. 63.5 years, p<0.0001); and age was a significant predictor of DNR by day 2 and mortality. In the adjusted analysis, however, age marginally influenced the racial disparity in mortality ( table ). Caucasians with coronary disease, atrial fibrillation, severe strokes and unable to walk prior to the stroke tend to be made DNR by day 2 more frequently. Only 27.1% of Caucasians with early DNR orders died in the hospital, whereas 20.8% were eventually discharged home. Conclusions: Early DNR orders result in a racial disparity in mortality from acute ischemic stroke. A substantial proportion of patients with early DNR orders eventually go home. Postponing the use of DNR orders may allow aggressive critical care interventions that may potentially mitigate the racial differences in mortality.

scholarly journals Renal impairment in stroke patients: A comparison between the haemorrhagic and ischemic variants

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1531
Author(s):  
Pratyush Shrestha ◽  
Shalima Thapa ◽  
Shikher Shrestha ◽  
Subash Lohani ◽  
Suresh BK ◽  
...  
Keyword(s):  
Renal Function ◽  
Ischemic Stroke ◽  
Renal Impairment ◽  
Estimated Glomerular Filtration Rate ◽  
Surgical Intervention ◽  
Haemorrhagic Stroke ◽  
Contributing Factors ◽  
Stroke Patients ◽  
The Mean ◽  
Function Testing

Background: Renal impairment is regularly seen in hospitalized stroke patients, affecting the outcome of patients, as well as causing difficulties in their management. A prospective cohort study was conducted to assess the trend of renal function in hospitalized ischemic and haemorrhagic stroke patients. The incidence of renal impairment in these subgroups, the contributing factors and the need for renal replacement in renal impaired patients was evaluated. Methods: Alternate day renal function testing was performed in hospitalized stroke patients. Estimated glomerular filtration rate (e-GFR) was calculated and the trend of renal function in the two stroke subgroups (haemorrhagic and ischemic) was assessed, with renal impairment defined as e-GFR < 60mL/ minute per 1.73m2. Results: Among 52 patients, 25 had haemorrhagic stroke (mean age 59.81 ± 14.67) and 27 had ischemic stroke (mean age 56.12 ± 13.08). The mean e-GFR (mL/minute per 1.732m2) at admission in the haemorrhagic stroke subgroup was 64.79 ± 25.85 compared to 86.04 ± 26.09 in the ischemic stroke subgroup (p=0.005). Sixteen out of 25 (64%) patients in the haemorrhagic stroke subgroup and 9 out of 27 (33.3%) patients in the ischemic subgroup developed renal impairment (p=0.027). The location of the bleed (p=0.8), volume of hematoma (p=0.966) and surgical intervention (p=0.4) did not predispose the patients to renal impairment. One out of 16 patients with haemorrhagic stroke (who eventually died), and 2 out of 9 patients with ischemic stroke required renal replacement. Conclusion: Renal impairment is commonly seen in stroke patients, more so in patients who suffered haemorrhagic strokes.  The impairment, however, is transient and rarely requires renal replacement therapy.

scholarly journals Association of Sickle Cell Trait With Ischemic Stroke Among African Americans

2018 ◽  
Vol 75 (7) ◽  
pp. 802 ◽  
Author(s):  
Hyacinth I. Hyacinth ◽  
Cara L. Carty ◽  
Samantha R. Seals ◽  
Marguerite R. Irvin ◽  
Rakhi P. Naik ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
African Americans ◽  
Sickle Cell ◽  
Sickle Cell Trait

scholarly journals Renal impairment in stroke patients: A comparison between the haemorrhagic and ischemic variants

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1531 ◽  
Author(s):  
Pratyush Shrestha ◽  
Shalima Thapa ◽  
Shikher Shrestha ◽  
Subash Lohani ◽  
Suresh BK ◽  
...  
Keyword(s):  
Renal Function ◽  
Ischemic Stroke ◽  
Renal Impairment ◽  
Estimated Glomerular Filtration Rate ◽  
Surgical Intervention ◽  
Haemorrhagic Stroke ◽  
Contributing Factors ◽  
Stroke Patients ◽  
The Mean ◽  
Function Testing

Background: Renal impairment is regularly seen in hospitalized stroke patients, affecting the outcome of patients, as well as causing difficulties in their management. A prospective cohort study was conducted to assess the trend of renal function in hospitalized ischemic and haemorrhagic stroke patients. The incidence of renal impairment in these subgroups, the contributing factors and the need for renal replacement in renal impaired patients was evaluated. Methods: Alternate day renal function testing was performed in hospitalized stroke patients. Estimated glomerular filtration rate (e-GFR) was calculated and the trend of renal function in the two stroke subgroups (haemorrhagic and ischemic) was assessed, with renal impairment defined as e-GFR < 60mL/ minute per 1.73m2. Results: Among 52 patients, 25 had haemorrhagic stroke (mean age 59.81 ± 14.67) and 27 had ischemic stroke (mean age 56.12 ± 13.08). The mean e-GFR (mL/minute per 1.732m2) at admission in the haemorrhagic stroke subgroup was 64.79 ± 25.85 compared to 86.04 ± 26.09 in the ischemic stroke subgroup (p=0.005). Sixteen out of 25 (64%) patients in the haemorrhagic stroke subgroup and 9 out of 27 (33.3%) patients in the ischemic subgroup developed renal impairment (p=0.27). The location of the bleed (p=0.8), volume of hematoma (p=0.966) and surgical intervention (p=0.4) did not predispose the patients to renal impairment. One out of 16 patients with haemorrhagic stroke (who eventually died), and 2 out of 9 patients with ischemic stroke required renal replacement. Conclusion: Renal impairment is commonly seen in stroke patients, more so in patients who suffered haemorrhagic strokes.  The impairment, however, is transient and rarely requires renal replacement therapy.

Abstract W MP57: Illicit Cocaine Use and Risk of Ischemic Stroke: The Stroke Prevention in Young Adults Study

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Yu-Ching Cheng ◽  
Saad A Qadwai ◽  
Kathleen A Ryan ◽  
John W Cole ◽  
Steven J Kittner
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
African Americans ◽  
African American Men ◽  
Smoking Status ◽  
Cocaine Use ◽  
Stroke Risk Factors ◽  
Increased Risk ◽  
History Of ◽  
Ethnic Subgroups

Background: Cocaine use has been associated with increased risk of ischemic stroke (IS). The prevalence of illicit cocaine use in the population differs by gender and ethnicity. The goal of this study was to determine the effect of cocaine on young-onset IS in Caucasian and African American men and women. Methods: A total of 1,101 cases and 1,154 controls, aged 15 to 49 years old, were recruited from the greater Baltimore-Washington area between 1992 and 2008. Cases and controls were interviewed to assess the presence of stroke risk factors and history of illicit drug use. Logistic regression was used to determine the association between cocaine use and IS. Results: In this study, 28% of cases and 26% of controls reported a history of illicit cocaine use. Men were twice as likely as women to report a history of cocaine use (36% vs. 18%, P<0.0001), and African Americans slightly more likely than Caucasians (30% vs. 26%, P=0.01). Having a history of illicit cocaine use was not associated with IS in the overall sample or any of the gender and ethnic subgroups. However, reporting acute use of cocaine in the 24 hours prior to stroke was strongly associated with increased risk of IS in the overall sample (2.4% of cases vs. 0.4% of controls; age-adjusted OR=7.1, 95% CI: 2.4-20.3), and the strength of association was similar in Caucasians (age-adjusted OR=6.1, p=0.10) and African Americans (age-adjusted OR=6.7, p=0.002). Interestingly, the effect of acute cocaine use appeared to be stronger in females (OR=12.8, p=0.01) than males (OR=2.5, p=0.17) after adjusting for the effect of age, ethnicity and current smoking status although the gender difference in ORs was not statistically significant. Conclusions: Our data suggests that acute cocaine use significantly increases IS risk in young adults, and that the effect appears to be stronger in women despite the lower frequency of cocaine use in this subgroup.

scholarly journals Changing Epidemiology of Stroke in Nepalese Population

2018 ◽  
Vol 15 (1) ◽  
pp. 10-18
Author(s):  
Amit Thapa ◽  
Bidur KC ◽  
Bikram Shakya ◽  
Dipesh Kumar Yadav ◽  
Karjome Lama ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Teaching Hospital ◽  
Hemorrhagic Stroke ◽  
Surgical Intervention ◽  
Vegetative State ◽  
College Teaching ◽  
Diabetic Patients ◽  
Medical College ◽  
First Time

Corrigendum:The article published in Nepal Journal of Neurosciences 2018;15:10-18 by Amit Thapa et al was mistakenlypublished with wrong affi liation of some of the co-authors. The correct affi liation of the co-authors should read asBikram Shakya, MBBS, MS, MChLecturerDepartment of Neurological SurgeryKathmandu Medical College Teaching Hospital (KMCTH)Sinamangal, Kathmandu, NepalDipesh Kumar Yadav, MBBSMedical OfficerDepartment of Neurological SurgeryKathmandu Medical College Teaching Hospital (KMCTH)Sinamangal, Kathmandu, NepalKarjome Lama, MBBSMedical OfficerDepartment of Neurological SurgeryKathmandu Medical College Teaching Hospital (KMCTH)Sinamangal, Kathmandu, Nepal Abstract: We are witnessing changing patterns in stroke in our practice. Documenting changes in epidemiological profile are important for public health policy. We hereby present analysis of patients with stroke to stress upon the dynamics and update the improvement in their care. We retrospectively studied all patients with first time stroke presenting in Kathmandu Medical College Teaching Hospital during June 2012 till November 2015. Diagnosis was made on clinico-radiological basis with prospective follow up for at least 1 year from the event. Risk factors as well outcome in terms of Glasgow outcome score were studied. Statistical analysis was performed on SPSS. A total of 1017 patients of 16260 patients admitted to the hospital during the study period had first time stroke, a hospital based annual incidence of stroke of 64 per thousand admissions was hence calculated. Mean age was 55 years with 60.5% males. 503 patients (49.5%) had infarction with 20 patients having hemorrhagic conversion while 3 had TIA. 50.2% had hemorrhagic stroke. 56.7% females had ischemic stroke whereas 54.9% of males had hemorrhagic stroke (p=0.002). Common risk factors like HTN (54.7%), Smoking (41.5%), Alcohol (39.2%), dyslipidemia (34.1%) and DM (4.8%) were seen with stroke however, active smoker were more at risk of hemorrhagic stroke (p=0.000) while diabetic patients for ischemic stroke (p=0.000). Due to availability of neurosurgical services, 14.6% patient could undergo procedures like decompressive craniectomy, hematoma evacuation, CSF diversion procedures and carotid endarterectomy for stroke. 66.9% patients required surgical intervention within 48 hours of admission. We had 30 days mortality of 0.5% mortality in this series (majority in hemorrhagic stroke), however over 3 years duration of study mortality rose to 8.3% (majority in ischemic stroke). Almost 88.5% patients achieved mRS< Nepal Journal of Neuroscience, Volume 15, Number 1, 2018 11 2 over a period of 3 years. Persistent vegetative state was seen in 7.6% cases after 1 year. We observe a very high incidence of hemorrhagic stroke in general with higher than reported proportion of females being involved with ischemic stroke in our series. Most of the vegetative state conditions occurred in ischemic stroke patients however early mortality was common in hemorrhagic stroke. This change in pattern of stroke as well as need of surgical intervention mandates early involvement of neurosurgical services. Poor long term prognosis in ischemic stroke may be reversed by timely thrombolytic services and prevented by mitigating risk factors. Nepal Journal of Neuroscience 15:10-18, 2018

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