The Role of Radiosurgery in the Treatment of Giant Arteriovenous Malformations

Radiosurgery ◽  
2002 ◽  
pp. 42-53
Author(s):  
S.D. Chang ◽  
R.P. Levy ◽  
M.P. Marks ◽  
M. Marcellus ◽  
G.K. Steinberg
Keyword(s):  
Arteriovenous Malformations

scholarly journals The Role Of Decompressive Hemnicraniectomies As Damage Control For Ruptured Intracranial Arteriovenous Malformations

2021 ◽  
pp. 101270
Author(s):  
Raphael Bertani ◽  
Stefan W. Koester ◽  
Karl R. Abi-Aad ◽  
Anna R. Kimata ◽  
Kevin L. Ma ◽  
...  
Keyword(s):  
Arteriovenous Malformations ◽  
Damage Control ◽  
Intracranial Arteriovenous Malformations

Advances in Radiosurgery for Arteriovenous Malformations of the Brain

Neurosurgery ◽  
2014 ◽  
Vol 74 (suppl_1) ◽  
pp. S50-S59 ◽  
Author(s):  
Benjamin A. Rubin ◽  
Andrew Brunswick ◽  
Howard Riina ◽  
Douglas Kondziolka
Keyword(s):  
Natural History ◽  
Stereotactic Radiosurgery ◽  
Endovascular Therapy ◽  
Arteriovenous Malformations ◽  
Morbidity And Mortality ◽  
Cerebral Arteriovenous Malformations ◽  
History Of ◽  
The Brain ◽  
Management Algorithms

Abstract Arteriovenous malformations of the brain are a considerable source of morbidity and mortality for patients who harbor them. Although our understanding of this disease has improved, it remains in evolution. Advances in our ability to treat these malformations and the modes by which we address them have also improved substantially. However, the variety of patient clinical and disease scenarios often leads us into challenging and complex management algorithms as we balance the risks of treatment against the natural history of the disease. The goal of this article is to provide a focused review of the natural history of cerebral arteriovenous malformations, to examine the role of stereotactic radiosurgery, to discuss the role of endovascular therapy as it relates to stereotactic radiosurgery, and to look toward future advances.

scholarly journals Arterial endoglin does not protect against arteriovenous malformations

Angiogenesis ◽  
2020 ◽  
Vol 23 (4) ◽  
pp. 559-566 ◽  
Author(s):  
Esha Singh ◽  
Rachael E. Redgrave ◽  
Helen M. Phillips ◽  
Helen M. Arthur
Keyword(s):  
Arteriovenous Malformations ◽  
Distal Part ◽  
Capillary Endothelium ◽  
Hereditary Haemorrhagic Telangiectasia ◽  
Vascular Disorder ◽  
Loss Of Function ◽  
Similar Frequency ◽  
Arterial Involvement ◽  
Time Point

Abstract Introduction Endoglin (ENG) forms a receptor complex with ALK1 in endothelial cells (ECs) to promote BMP9/10 signalling. Loss of function mutations in either ENG or ALK1 genes lead to the inherited vascular disorder hereditary haemorrhagic telangiectasia (HHT), characterised by arteriovenous malformations (AVMs). However, the vessel-specific role of ENG and ALK1 proteins in protecting against AVMs is unclear. For example, AVMs have been described to initiate in arterioles, whereas ENG is predominantly expressed in venous ECs. To investigate whether ENG has any arterial involvement in protecting against AVM formation, we specifically depleted the Eng gene in venous and capillary endothelium whilst maintaining arterial expression, and investigated how this affected the incidence and location of AVMs in comparison with pan-endothelial Eng knockdown. Methods Using the mouse neonatal retinal model of angiogenesis, we first established the earliest time point at which Apj-Cre-ERT2 activity was present in venous and capillary ECs but absent from arterial ECs. We then compared the incidence of AVMs following pan-endothelial or venous/capillary-specific ENG knockout. Results Activation of Apj-Cre-ERT2 with tamoxifen from postnatal day (P) 5 ensured preservation of arterial ENG protein expression. Specific loss of ENG expression in ECs of veins and capillaries led to retinal AVMs at a similar frequency to pan-endothelial loss of ENG. AVMs occurred in the proximal as well as the distal part of the retina consistent with a defect in vascular remodelling during maturation of the vasculature. Conclusion Expression of ENG is not required in arterial ECs to protect against AVM formation.

scholarly journals Role of Superselective Angiography in the Detection and Endovascular Treatment of Ruptured Occult Arteriovenous Malformations

2001 ◽  
Vol 7 (4) ◽  
pp. 303-311 ◽  
Author(s):  
M. Tanaka ◽  
A. Valavanis
Keyword(s):  
Intracerebral Hemorrhage ◽  
Cerebral Angiography ◽  
Arteriovenous Malformations ◽  
Perimesencephalic Subarachnoid Hemorrhage ◽  
First Case ◽  
Superselective Embolization ◽  
Venous Filling ◽  
Superselective Angiography ◽  
Endovascular Approach

Three cases of occult micro-arteriovenous malformations not identified by cerebral angiography or other imaging modalities were detected by superselective angiography. The first case had a small intracerebral hemorrhage in the superior colliculus, the second had a perimesencephalic subarachnoid hemorrhage, and the third presented with intracerebral hemorrhage combined with massive intraventricular hematoma. While repeated selective cerebral angiography (four-vessel study) was negative, superselective angiography clearly demonstrated each lesion with small early venous filling in accordance with the location of hematoma. Successful superselective embolization with polyvinyl alcohol particles was performed in each micro-arteriovenous malformation by flow-guided microcatheter without postoperative complications. Our experience suggests that superselective angiography is necessary to visualize micro-arteriovenous malformations in patients with cerebral hemorrhage and negative four-vessel angiography. Furthermore, the superselective endovascular approach has the advantage of offering immediate obliteration of the micro-shunt, thereby reducing or eliminating the risk of further hemorrhage.

The Role of Radiosurgery for Infratentorial Arteriovenous Malformations

2014 ◽  
Vol 82 (1-2) ◽  
pp. e85-e86
Author(s):  
Aditya Iyer ◽  
Steven D. Chang
Keyword(s):  
Arteriovenous Malformations

Assessing the Role of Preoperative Embolization in the Surgical Management of Cerebral Arteriovenous Malformations

2017 ◽  
Vol 104 ◽  
pp. 430-441 ◽  
Author(s):  
Andrew S. Luksik ◽  
Jody Law ◽  
Wuyang Yang ◽  
Tomas Garzon-Muvdi ◽  
Justin M. Caplan ◽  
...  
Keyword(s):  
Surgical Management ◽  
Arteriovenous Malformations ◽  
Preoperative Embolization ◽  
Cerebral Arteriovenous Malformations
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