CNS Drug Delivery for Movement Disorders

2000 ◽  
pp. 371-380
Author(s):  
R.D. Penn ◽  
J.S. Kroin
Keyword(s):  
Drug Delivery ◽  
Movement Disorders ◽  
Cns Drug Delivery

Nanocarriers as CNS Drug Delivery Systems for Enhanced Neuroprotection

2017 ◽  
pp. 33-55 ◽  
Author(s):  
Asya Ozkizilcik ◽  
Parker Davidson ◽  
Hulusi Turgut ◽  
Hari S. Sharma ◽  
Aruna Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cns Drug Delivery

scholarly journals NanoART, neuroAIDS and CNS drug delivery

Nanomedicine ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. 557-574 ◽  
Author(s):  
Ari Nowacek ◽  
Howard E Gendelman
Keyword(s):  
Drug Delivery ◽  
Cns Drug Delivery

Nasal-to-CNS drug delivery: where are we now and where are we heading? An industrial perspective

2012 ◽  
Vol 3 (2) ◽  
pp. 195-208 ◽  
Author(s):  
Margaret S Landis ◽  
Tracey Boyden ◽  
Simon Pegg
Keyword(s):  
Drug Delivery ◽  
Cns Drug Delivery

The use of microdialysis in CNS drug delivery studies

2000 ◽  
Vol 45 (2-3) ◽  
pp. 283-294 ◽  
Author(s):  
Margareta Hammarlund-Udenaes
Keyword(s):  
Drug Delivery ◽  
Cns Drug Delivery

Abstract 6251: Blood brain barrier opening by TTFields: a future CNS drug delivery strategy

2020 ◽  
Author(s):  
Ellaine Salvador ◽  
Almuth F. Kessler ◽  
Julia Hörmann ◽  
Malgorzata Burek ◽  
Catherine T. Brami ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Delivery Strategy ◽  
Cns Drug Delivery ◽  
Blood Brain ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

scholarly journals Shortcut Approaches to Substance Delivery into the Brain Based on Intranasal Administration Using Nanodelivery Strategies for Insulin

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5188
Author(s):  
Toshihiko Tashima
Keyword(s):  
Drug Delivery ◽  
Olfactory Epithelium ◽  
Olfactory Nerve ◽  
Brain Drug Delivery ◽  
Cns Drug Delivery ◽  
Capillary Endothelial Cells ◽  
Alternative Approaches ◽  
Cns Drugs ◽  
Direct Delivery ◽  
The Brain

The direct delivery of central nervous system (CNS) drugs into the brain after administration is an ideal concept due to its effectiveness and non-toxicity. However, the blood–brain barrier (BBB) prevents drugs from penetrating the capillary endothelial cells, blocking their entry into the brain. Thus, alternative approaches must be developed. The nasal cavity directly leads from the olfactory epithelium to the brain through the cribriform plate of the skull bone. Nose-to-brain drug delivery could solve the BBB-related repulsion problem. Recently, it has been revealed that insulin improved Alzheimer’s disease (AD)-related dementia. Several ongoing AD clinical trials investigate the use of intranasal insulin delivery. Related to the real trajectory, intranasal labeled-insulins demonstrated distribution into the brain not only along the olfactory nerve but also the trigeminal nerve. Nonetheless, intranasally administered insulin was delivered into the brain. Therefore, insulin conjugates with covalent or non-covalent cargos, such as AD or other CNS drugs, could potentially contribute to a promising strategy to cure CNS-related diseases. In this review, I will introduce the CNS drug delivery approach into the brain using nanodelivery strategies for insulin through transcellular routes based on receptor-mediated transcytosis or through paracellular routes based on escaping the tight junction at the olfactory epithelium.

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