Chemoprotection against Cytosine Nucleoside Analogs Using the Human Cytidine Deaminase Gene

1999 ◽  
pp. 124-142 ◽  
Author(s):  
N. Eliopoulos ◽  
C. Beaus�jour ◽  
R.L. Momparler
Keyword(s):  
Cytidine Deaminase ◽  
Nucleoside Analogs

scholarly journals Selection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene

2001 ◽  
Vol 8 (9) ◽  
pp. 669-676 ◽  
Author(s):  
Christian M Beauséjour ◽  
Nicoletta Eliopoulos ◽  
Louise Momparler ◽  
Ngoc Loan Oanh Le ◽  
Richard L Momparler
Keyword(s):  
Cytidine Deaminase ◽  
Nucleoside Analogs ◽  
Drug Resistant ◽  
Selection Of

Sensitivity of some arabinosylcytosine derivatives to enzymatic deamination by cytidine deaminase from mouse kidney

1982 ◽  
Vol 47 (10) ◽  
pp. 2824-2830 ◽  
Author(s):  
Jindřich Kára ◽  
Markyta Bártová ◽  
Miloš Ryba ◽  
Hubert Hřebabecký ◽  
Josef Brokeš ◽  
...  
Keyword(s):  
Cytidine Deaminase ◽  
Nucleoside Analogs ◽  
Mouse Kidney ◽  
Derivatives Of ◽  
Uracil Derivative

Enzymatic deamination of derivatives of arabinosylcytosine by partially purified cytidine deaminase isolated from mouse kidney is studied. The rate of deamination of 5'-chloroarabinosylcytosine (Ia), 5'-bromoarabinosylcytosine (Ib), 5'-chlorocyclocytidine (II), and 2',5'-anhydroarabinosylcytosine (III) is compared with that of arabinosylcytosine, of its N4-acetyl-, tri-O-acetyl-, tetraacetyl derivatives and of cyclocytidine. The deamination of the anhydro derivative III to the corresponding uracil derivative IV proceeds significantly slower than that of arabinosylcytosine, and comparably to that of cyclocytidine. The deamination of the 5'-halogeno derivatives Ia, Ib and II proceeds via the anhydro derivative III to IV. Some of the known arabinosylcytosine derivatives, cyclocytidine, N4-acetyl-, tetraacetyl- and tri-O-acetyl derivatives, show a resistance to enzymatic deamination. Different nucleoside analogs are tested as inhibitors of deaminase; only 2-β-D-ribofuranosyl-1,2,4-triazol-3-one possesses some activity.

Sign in / Sign up

Export Citation Format

Share Document