Protection of Bone Marrow Cells from Toxicity of Chemotherapeutic Agents Targeted toward Thymidylate Synthase by Transfer of Mutant Forms of Human Thymidylate Synthase cDNA

1999 ◽  
pp. 107-114 ◽  
Author(s):  
D. Banerjee ◽  
Y. Tong ◽  
X. Liu-Chen ◽  
G. Capiaux ◽  
E.A. Ercikan-Abali ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Thymidylate Synthase ◽  
Bone Marrow Cells ◽  
Chemotherapeutic Agents ◽  
Mutant Forms ◽  
Marrow Cells

scholarly journals Studies on the Uptake of Synthetic Conjugated Folates by Human Marrow Cells

Blood ◽  
1973 ◽  
Vol 42 (1) ◽  
pp. 141-146 ◽  
Author(s):  
A. V. Hoffbrand ◽  
Edith Tripp ◽  
Catherine M. Houlihan ◽  
J. M. Scott
Keyword(s):  
Bone Marrow ◽  
Folic Acid ◽  
Dna Synthesis ◽  
Lactobacillus Casei ◽  
Bone Marrow Cells ◽  
Megaloblastic Anemia ◽  
Chemotherapeutic Agents ◽  
Hemopoietic Cells ◽  
Marrow Cells

Abstract Pteroyltriglutamate shows little abiility (between 1% and 5%), compared to pteroylmonoglutamate (folic acid), to enter human marrow cells and to act as a coenzyme in intracellular DNA synthesis. This was shown by comparing the effectiveness of these two forms of the vitamin at stimulating folate-dependent pyrimidine incorporation into DNA in vitro in the bone marrow cells and lymphocytes of patients with megaloblastic anemia. It, therefore, appears that human hemopoietic cells (like Streptococcus fecalis rather than Lactobacillus casei) are unable to take up efficiently polyglutamyl forms of folate. The suggestion that polyglutamyl analogues of the antifolates might be more effective chemotherapeutic agents than corresponding monoglutamates, while biochemically possible, would appear to be precluded because of failure of transport of these compounds into human hemopoietic cells.

Transplanted Bone Marrow Cells Do Not Provide New Oocytes But Rescue Fertility in Female Mice Following Treatment With Chemotherapeutic Agents

2012 ◽  
Vol 14 (2) ◽  
pp. 123-129 ◽  
Author(s):  
Nicolas Santiquet ◽  
Luc Vallières ◽  
François Pothier ◽  
Marc-André Sirard ◽  
Claude Robert ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Chemotherapeutic Agents ◽  
Female Mice ◽  
Marrow Cells

CABG and intramyocardial delivery of CD133+ bone marrow cells: 3-years follow-up on safety and efficacy

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
C Stamm ◽  
YH Choi ◽  
A Liebold ◽  
HD Kleine ◽  
S Dunkelmann ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Safety And Efficacy ◽  
Intramyocardial Delivery ◽  
Marrow Cells
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