Transforming Genes of Human Cytomegalovirus and Human Herpesvirus 6

2001 ◽  
pp. 88-106
Author(s):  
S. Muralidhar ◽  
L.J. Rosenthal
Keyword(s):  
Human Cytomegalovirus ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Transforming Genes

Quantitative analysis of human herpesvirus-6 and human cytomegalovirus in blood and saliva from patients with acute leukemia

2014 ◽  
Vol 87 (3) ◽  
pp. 451-460 ◽  
Author(s):  
Faten Nefzi ◽  
Nabil Abid Ben Salem ◽  
Abderrahim Khelif ◽  
Salma Feki ◽  
Mahjoub Aouni ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Acute Leukemia ◽  
Human Cytomegalovirus ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

scholarly journals A 6-Aminoquinolone Compound, WC5, with Potent and Selective Anti-Human Cytomegalovirus Activity

2008 ◽  
Vol 53 (1) ◽  
pp. 312-315 ◽  
Author(s):  
Beatrice Mercorelli ◽  
Giulia Muratore ◽  
Elisa Sinigalia ◽  
Oriana Tabarrini ◽  
Maria Angela Biasolo ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Human Herpesvirus ◽  
Selectivity Index ◽  
Murine Cytomegalovirus ◽  
Drug Resistant ◽  
Human Herpesvirus 6 ◽  
Hcmv Replication ◽  
Herpesvirus 6

ABSTRACT We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of ∼500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was ∼10-fold less active against murine cytomegalovirus. Thus, WC5 may represent a lead for the development of new, potent, and selective anti-HCMV compounds.

Human herpesvirus 6 is closely related to human cytomegalovirus.

1990 ◽  
Vol 64 (1) ◽  
pp. 287-299 ◽  
Author(s):  
G L Lawrence ◽  
M Chee ◽  
M A Craxton ◽  
U A Gompels ◽  
R W Honess ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

scholarly journals Impact of Human Cytomegalovirus and Human Herpesvirus 6 Infection on the Expression of Factors Associated with Cell Fibrosis and Apoptosis: Clues for Implication in Systemic Sclerosis Development

2020 ◽  
Vol 21 (17) ◽  
pp. 6397
Author(s):  
Maria-Cristina Arcangeletti ◽  
Maria D’Accolti ◽  
Clara Maccari ◽  
Irene Soffritti ◽  
Flora De Conto ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Human Cytomegalovirus ◽  
Human Herpesvirus ◽  
Dermal Fibroblasts ◽  
Target Cells ◽  
Human Herpesvirus 6 ◽  
Factors Associated ◽  
Herpesvirus 6

Systemic sclerosis (SSc) is a severe autoimmune disorder characterized by vasculopathy and multi-organ fibrosis; its etiology and pathogenesis are still largely unknown. Herpesvirus infections, particularly by human cytomegalovirus (HCMV) and human herpesvirus 6 (HHV-6), have been suggested among triggers of the disease based on virological and immunological observations. However, the direct impact of HCMV and/or HHV-6 infection on cell fibrosis and apoptosis at the cell microenvironment level has not yet been clarified. Thus, this study aimed to investigate the effects of HCMV and HHV-6 infection on the induction of pro-fibrosis or pro-apoptosis conditions in primary human dermal fibroblasts, one of the relevant SSc target cells. The analysis, performed by microarray in in vitro HCMV- or HHV-6-infected vs. uninfected cells, using specific panels for the detection of the main cellular factors associated with fibrosis or apoptosis, showed that both viruses significantly modified the expression of at least 30 pro-fibrotic and 20 pro-apoptotic factors. Notably, several recognized pro-fibrotic factors were highly induced, and most of them were reported to be involved in vivo in the multifactorial and multistep pathogenic process of SSc, thus suggesting a potential role of both HCMV and HHV-6.

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