Inflammatory Response and Adhesion Molecules in Focal Cerebral Ischemia

1997 ◽  
pp. 46-64
Author(s):  
Z.G. Zhang ◽  
M. Chopp
Keyword(s):  
Cerebral Ischemia ◽  
Inflammatory Response ◽  
Adhesion Molecules ◽  
Focal Cerebral Ischemia

Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats

2013 ◽  
Vol 24 (12) ◽  
pp. 2127-2137 ◽  
Author(s):  
Cheng-Yi Chang ◽  
Yu-Hsiang Kuan ◽  
Jian-Ri Li ◽  
Wen-Ying Chen ◽  
Yen-Chuan Ou ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Docosahexaenoic Acid ◽  
Inflammatory Response ◽  
Focal Cerebral Ischemia ◽  
Cellular Inflammatory Response

scholarly journals Deficiency of Intercellular Adhesion Molecule 1 Attenuates Microcirculatory Disturbance and Infarction Size in Focal Cerebral Ischemia

1998 ◽  
Vol 18 (12) ◽  
pp. 1336-1345 ◽  
Author(s):  
Kazuo Kitagawa ◽  
Masayasu Matsumoto ◽  
Takuma Mabuchi ◽  
Yoshiki Yagita ◽  
Toshiho Ohtsuki ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Knockout Mice ◽  
Focal Cerebral Ischemia ◽  
Focal Ischemia ◽  
Intercellular Adhesion Molecule ◽  
Wild Type ◽  
Intercellular Adhesion Molecule 1 ◽  
Transient Focal Ischemia

Recent evidence has shown crucial roles for cell-adhesion molecules in inflammation-induced rolling, adhesion, and accumulation of neutrophils in tissue. Intercellular adhesion molecule-1 (ICAM-1) is one of these adhesion molecules. Previous studies have shown marked reduction in the size of infarction after focal cerebral ischemia by depletion of granulocytes and administration of the antibody against ICAM-1. In the present study we investigated the role of ICAM-1 in the size of ischemic lesions, accumulation of granulocytes, and microcirculatory compromise in focal cerebral ischemia by using ICAM-1–knockout mice. Ischemic lesions were significantly mitigated in knockout mice after permanent and transient focal ischemia, even though the number of granulocytes in the infarcted tissue was almost the same between knockout and wild-type mice. Depletion of granulocytes further decreased the size of ischemic lesions after transient focal ischemia in ICAM-1–knockout mice. Microcirculation was reduced after focal ischemia, but it was better preserved in the cerebral cortex of knockout mice than that of wild-type mice. The present study demonstrated that ICAM-1 played a role in microcirculatory failure and subsequent development and expansion of infarction after focal cerebral ischemia. However, it is highly unlikely that ICAM-1 played a key role in accumulation of granulocytes after focal cerebral ischemia.

scholarly journals Suppression of the inflammatory response by diphenyleneiodonium after transient focal cerebral ischemia

2012 ◽  
Vol 123 ◽  
pp. 98-107 ◽  
Author(s):  
Simon Nagel ◽  
Gina Hadley ◽  
Karin Pfleger ◽  
Caesar Grond-Ginsbach ◽  
Alastair Mitchell Buchan ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Inflammatory Response ◽  
Focal Cerebral Ischemia ◽  
Transient Focal Cerebral Ischemia

Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats

2013 ◽  
Vol 247 ◽  
pp. 188-201 ◽  
Author(s):  
Tsung-Kuei Kao ◽  
Cheng-Yi Chang ◽  
Yen-Chuan Ou ◽  
Wen-Ying Chen ◽  
Yu-Hsiang Kuan ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Inflammatory Response ◽  
Focal Cerebral Ischemia ◽  
Cellular Inflammatory Response
Sign in / Sign up

Export Citation Format

Share Document