Neurobiology of OB Protein (Leptin)

1999 ◽  
pp. 1-11
Author(s):  
L.A. Campfield
Keyword(s):  
Ob Protein

Interaction of the OB protein pathway with other brain mechanisms: Impact on metabolic state

2009 ◽  
Vol 105 (S 03) ◽  
pp. 34-35 ◽  
Author(s):  
L. Arthur Campfield ◽  
Françoise J. Smith ◽  
Jarema P. Kochan ◽  
Keith A. Yagaloff ◽  
Paul Burn
Keyword(s):  
Metabolic State ◽  
Ob Protein

OB Protein: A Peripheral Signal Linking Adiposity and Central Neural Networks

Appetite ◽  
1996 ◽  
Vol 26 (3) ◽  
pp. 302 ◽  
Author(s):  
L.A. CAMPFIELD ◽  
F.J. SMITH ◽  
R. DEVOS ◽  
P. BURN ◽  
Y. GUISEZ
Keyword(s):  
Neural Networks ◽  
Protein A ◽  
Ob Protein

scholarly journals Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats

1997 ◽  
Vol 272 (2) ◽  
pp. R726-R730 ◽  
Author(s):  
T. E. Thiele ◽  
G. Van Dijk ◽  
L. A. Campfield ◽  
F. J. Smith ◽  
P. Burn ◽  
...  
Keyword(s):  
Side Effects ◽  
Food Intake ◽  
Consummatory Behavior ◽  
Central Administration ◽  
Short Term ◽  
Nonspecific Effects ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Ob Protein

Leptin (ob protein) and glucagon-like peptide-1-(7-36) amide (GLP-1) are peptides recently proposed to be involved in the regulation of food intake. Although the ability of exogenous leptin and GLP-1 to modulate consummatory behavior is consistent with the suggestion that these peptides are endogenous regulatory agents, central administration of these peptides may have aversive side effects, which could explain the anorexia. In the present experiment, exposure to a saccharine taste was immediately followed by central administration of leptin or GLP-1 to determine if these drugs could produce a conditioned taste aversion (CTA) in rats. At doses equated for producing comparable reductions in short-term food intake, GLP-1, but not leptin, generated a robust CTA. Although leptin caused no aversion, this peptide was the only drug to cause relatively long-term reductions in food consumption (16 h) and body weight (24 h). Hence, the results indicate that central GLP-1 produces aversive side effects, and it is argued that these nonspecific effects may explain the anorectic actions of GLP-1.

Efficient Secretion of Biologically Active Recombinant OB Protein (Leptin) inEscherichia coli,Purification from the Periplasm and Characterization

1998 ◽  
Vol 12 (2) ◽  
pp. 249-258 ◽  
Author(s):  
Yves Guisez ◽  
Ina Faché ◽  
L.Arthur Campfield ◽  
Françoise J. Smith ◽  
Adrienne Farid ◽  
...  
Keyword(s):  
Biologically Active ◽  
Inescherichia Coli ◽  
Ob Protein

Mode of action of OB protein (leptin) on feeding

1998 ◽  
Vol 275 (1) ◽  
pp. R174-R179 ◽  
Author(s):  
Mark C. Flynn ◽  
Thomas R. Scott ◽  
Thomas C. Pritchard ◽  
Carlos R. Plata-Salamán
Keyword(s):  
Food Intake ◽  
Wistar Rats ◽  
Feeding Rate ◽  
Meal Size ◽  
Meal Frequency ◽  
Dependent Manner ◽  
Intracerebroventricular Administration ◽  
Ad Libitum ◽  
Ob Protein ◽  
Dose Dependent

OB protein (leptin) decreases food intake in a variety of species. Here we investigated the effects of the intracerebroventricular administration of recombinant murine OB protein on food consumption and meal parameters in Wistar rats maintained ad libitum. The intracerebroventricular administration of OB protein (0.56–3.5 μg/rat) decreased feeding in a dose-dependent manner. Computer analysis of meal parameters demonstrated that OB protein (3.5 μg/rat, n = 10) decreased nighttime meal size by 42%, whereas meal frequency and meal duration were unaffected. Derived analyses for the nighttime also showed that OB protein decreased the feeding rate (meal size/meal duration) by 30%, whereas the satiety ratio (intermeal intervals/meal size) increased by 100%. A similar profile was observed during the daytime and total daily periods. The intracerebroventricular administration of heat-inactivated OB protein (3.5 μg/rat, n = 10) had no effect on any meal parameter. The results show that OB protein administered intracerebroventricularly inhibits feeding through a specific reduction of meal size.

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

Science ◽  
1995 ◽  
Vol 269 (5223) ◽  
pp. 546-549 ◽  
Author(s):  
L. Campfield ◽  
F. Smith ◽  
Y Guisez ◽  
R Devos ◽  
P Burn
Keyword(s):  
Neural Networks ◽  
Recombinant Mouse ◽  
Ob Protein

scholarly journals Overview: neurobiology of OB protein (leptin)

1998 ◽  
Vol 57 (3) ◽  
pp. 429-440 ◽  
Author(s):  
L. Arthur Campfield ◽  
Françoise J. Smith
Keyword(s):  
Ob Protein

scholarly journals Decreased food intake does not completely account for adiposity reduction after ob protein infusion.

1996 ◽  
Vol 93 (4) ◽  
pp. 1726-1730 ◽  
Author(s):  
N. Levin ◽  
C. Nelson ◽  
A. Gurney ◽  
R. Vandlen ◽  
F. de Sauvage
Keyword(s):  
Food Intake ◽  
Ob Protein

scholarly journals Recombinant ob protein reduces feeding and body weight in the ob/ob mouse.

1995 ◽  
Vol 96 (4) ◽  
pp. 2065-2070 ◽  
Author(s):  
D S Weigle ◽  
T R Bukowski ◽  
D C Foster ◽  
S Holderman ◽  
J M Kramer ◽  
...  
Keyword(s):  
Body Weight ◽  
Ob Protein

OB Protein

2010 ◽  
pp. 909-909
Author(s):  
Tooru M. Mizuno ◽  
Ashwini Padhi ◽  
Naomi Fineberg ◽  
Naomi A. Fineberg ◽  
Ashwini Padhi ◽  
...  
Keyword(s):  
Ob Protein
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