Modulation of Melatonin Secretion in Cancer Patients. Possible Mechanisms and Significance for Prognosis, Diagnosis and Treatment

1997 ◽  
pp. 115-124
Author(s):  
C. Bartsch ◽  
H. Bartsch
Keyword(s):  
Cancer Patients ◽  
Diagnosis And Treatment ◽  
Melatonin Secretion

Serum Levels of Melatonin in Cancer Patients and their Relation to Body Sizes

1988 ◽  
Vol 3 (3) ◽  
pp. 193-196 ◽  
Author(s):  
S. Barni ◽  
P. Lissoni ◽  
S. Crispino ◽  
F. Rovelli ◽  
G. Esposti ◽  
...  
Keyword(s):  
Body Weight ◽  
Body Size ◽  
Cancer Patients ◽  
Serum Levels ◽  
Blood Levels ◽  
Melatonin Secretion ◽  
Normal Range ◽  
Blood Concentrations ◽  
Patients With Cancer ◽  
Body Sizes

Melatonin secretion is often enhanced in patients with cancer. In the light of a reported correlation between melatonin levels and body size, we investigated blood levels of this pineal hormone in a group of 72 patients affected by cancer, 30 of whom had body weight within the normal range, 30 were obese and the last 12 cases had body weight below the normal range, in order to establish whether in fact melatonin blood concentrations were related to body size. Melatonin levels were high in 19/72 patients (26%). The mean levels of the pineal hormone were similar in patients with normal, low and high body weight. Finally, there was no significant correlation between melatonin values and body weight, height or surface. Melatonin secretion thus does not appear to be influenced by body size in cancer patients.

376 Single MRI can be used in both diagnosis and treatment planning in head and neck cancer patients

2005 ◽  
Vol 76 ◽  
pp. S167-S168
Author(s):  
M. Gardner ◽  
P. Halimi ◽  
D. Valinta ◽  
M.M. Plantet ◽  
A. Banal ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Treatment Planning ◽  
Neck Cancer ◽  
Diagnosis And Treatment

scholarly journals Ten-year experience of the Pirogov Center in the organization of oncological care in a multi-field hospital

2019 ◽  
Vol 24 (3) ◽  
pp. 115-123
Author(s):  
Yu. L. Shevchenko ◽  
O. E. Karpov ◽  
V. O. Sarzhevskiy ◽  
S. A. Fateev ◽  
P. S. Vetshev ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Medical Care ◽  
Cancer Patients ◽  
Multidisciplinary Approach ◽  
Diagnosis And Treatment ◽  
High Tech ◽  
Care Organization ◽  
Field Hospital ◽  
National Medical ◽  
Oncological Care

Organizational aspects of specialized including high-tech oncological medical care in a multi-field hospital are shown. A 10-year experience of the Pirogov National Medical and Surgical Center regarding optimization of the treatment of cancer patients is reported. Effectiveness of oncological care organization in a multi-field hospital is preliminary concluded. It is emphasized that multidisciplinary approach is essential for selecting a personalized program of cancer treatment in these patients. The need for further searching for ways to improve the diagnosis and treatment of cancer patients by accumulating and analyzing large clinical material is marked.

The pathway to diagnosis and treatment for surgically managed lung cancer patients

2019 ◽  
Author(s):  
Victoria White ◽  
Rebecca J Bergin ◽  
Robert J Thomas ◽  
Kathryn Whitfield ◽  
David Weller
Keyword(s):  
Lung Cancer ◽  
Primary Care ◽  
Cancer Patients ◽  
Secondary Care ◽  
Primary Care Physicians ◽  
Treatment Time ◽  
Early Stage ◽  
Diagnosis And Treatment ◽  
Early Stage Disease ◽  
Lung Cancer Patients

Abstract Background Most lung cancer is diagnosed at an advanced stage, resulting in poor survival. This study examined diagnostic pathways for patients with operable lung cancer to identify factors contributing to early diagnosis. Methods Surgically treated lung cancer patients (aged ≥40, within 6 months of diagnosis), approached via the population-based Cancer Registry, with their primary care physicians (PCPs) and specialists completed cross-sectional surveys assessing symptoms, diagnostic route (symptomatic or ‘investigation’ of other problem), tests, key event dates and treatment. Time intervals to diagnosis and treatment were determined, and quantile regression examined differences between the two diagnostic routes. Cox proportional hazard regression analyses examined associations between survival and diagnostic route adjusting for stage, sex and age. Results One hundred and ninety-two patients (36% response rate), 107 PCPs and 55 specialists participated. Fifty-eight per cent of patients had a symptomatic diagnostic route reporting an average of 1.6 symptoms, most commonly cough, fatigue or haemoptysis. Symptomatic patients had longer median primary care interval than ‘investigation’ patients (12 versus 9 days, P < 0.05) and were more likely to report their PCP first-ordered imaging tests. Secondary care interval was shorter for symptomatic (median = 43 days) than investigation (median = 62 days, P < 0.05) patients. However, 56% of all patients waited longer than national recommendations (6 weeks). While survival estimates were better for investigation than symptomatic patients, these differences were not significant. Conclusion Many operable lung cancer patients are diagnosed incidentally, highlighting the difficulty of symptom-based approaches to diagnosing early stage disease. Longer than recommended secondary care interval suggests the need for improvements in care pathways.

scholarly journals The lingering mysteries of metastatic recurrence in breast cancer

2020 ◽  
Vol 124 (1) ◽  
pp. 13-26
Author(s):  
Alessandra I. Riggio ◽  
Katherine E. Varley ◽  
Alana L. Welm
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Metastatic Disease ◽  
Systemic Therapy ◽  
Initial Diagnosis ◽  
Diagnosis And Treatment ◽  
Breast Cancer Patients ◽  
Key Factors ◽  
Metastatic Recurrence ◽  
Metastatic Relapse

AbstractDespite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or systemic therapy, owing to relapse or recurrence. In the case of breast cancer, metastatic relapse can occur months to decades after initial diagnosis and treatment. In this review, we provide an overview of the known key factors that influence metastatic recurrence, with the goal of highlighting the critical unanswered questions that still need to be addressed to make a difference in the mortality of breast cancer patients.

scholarly journals Diagnosis and treatment pattern among rural and urban breast cancer patients in Southwest China from 2005 to 2009

Oncotarget ◽  
2016 ◽  
Vol 7 (47) ◽  
pp. 78168-78179 ◽  
Author(s):  
Zuxiang Peng ◽  
Jia Wei ◽  
Xuesong Lu ◽  
Hong Zheng ◽  
Xiaorong Zhong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Southwest China ◽  
Treatment Pattern ◽  
Diagnosis And Treatment ◽  
Breast Cancer Patients ◽  
Rural And Urban

Distress Management

2007 ◽  
Vol 5 (1) ◽  
pp. 66 ◽  
Author(s):  
_ _
Keyword(s):  
Clinical Practice ◽  
Cancer Patients ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Cancer Care ◽  
Diagnosis And Treatment ◽  
Ambulatory Setting ◽  
Waiting Room ◽  
Patients Experience ◽  
Recent Version

All patients experience some level of distress at various stages of the diagnosis and treatment of cancer. Physicians' ability to recognize patients' distress has become more challenging as cancer care has shifted to the ambulatory setting, where visits are often short and rushed. Therefore, using clinical practice guidelines for managing psychosocial distress in cancer patients is critical. These guidelines recommend that each new patient be rapidly assessed in the office or clinic waiting room for evidence of distress. For the most recent version of the guidelines, please visit NCCN.org

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