Relationship between the Pineal Gland and Experimentally Induced Malignant Tumors

1997 ◽  
pp. 99-106 ◽  
Author(s):  
M. Karasek
Keyword(s):  
Pineal Gland ◽  
Malignant Tumors ◽  
Experimentally Induced

scholarly journals Relationship of the content of vitamin D and melatonin in blood serum and pineal gland calcifications in patients with malignant bone tumors

2021 ◽  
Vol 9 (1) ◽  
pp. 63-69
Author(s):  
Oleg Drobotun ◽  
Mykola Kolotilov ◽  
Mykola Safonov
Keyword(s):  
Vitamin D ◽  
Pineal Gland ◽  
Blood Serum ◽  
Vitamin D Deficiency ◽  
Bone Tumors ◽  
Malignant Tumors ◽  
Lower Extremities ◽  
Malignant Bone Tumors ◽  
Relationship Of ◽  
The Relationship

The aim of the study was to investigate the relationship between the vitamin D content, melatonin and the characteristics of pineal gland calcifications in patients with malignant tumors of the bones of the lower extremities. Vitamin D deficiency and pineal gland calcifications are observed in almost 100 % of patients with malignant tumors of the lower extremities’ bones. The high heterogeneity of calcifications and its dynamics during the treatment of patients may indicate the processes of their litholysis and dissolution.

scholarly journals Pineal gland calcifications in patients with benign and malignant tumors of the larynx, pharynx, paranasal sinuses and auditory nerve

2020 ◽  
pp. 18-27
Author(s):  
Nikolay Kolotilov
Keyword(s):  
Pineal Gland ◽  
Paranasal Sinuses ◽  
Auditory Nerve ◽  
Malignant Tumors ◽  
Prostate Gland ◽  
The Body ◽  
Surgical Interventions ◽  
Lateral Ventricles ◽  
Body Tissues ◽  
Choroid Plexuses

Calcifications of the brain – pineal gland, choroid plexuses of the lateral ventricles – are a long-known phenomenon. Calcification in such functionally important organs as the pineal gland and choroid plexuses of the lateral ventricles cannot be physiological (it is enough to recall the formation of stones in the gallbladder, kidneys, prostate gland, calcinosis of the heart valves and coronary vessels) or relatively neutral process in the body and not affect the activity of these organs. The purpose of the investigation is to study the nosological predisposition of calcifications and the incidence of calcification of the pineal gland and choroid plexuses of the lateral ventricles in benign and malignant tumors of the larynx, pharynx, paranasal sinuses and auditory nerve. Material and research methods. The analysis of CT images of 425 persons was carried out (data archive of the Institute): 50 practically healthy persons from 22 to 60 years without any chronic diseases of the head and neck and a history of surgical interventions; 23 – from 61 to 74 years with normal body aging, not taking any medications, with healthy lifestyle; 235 – from 22 to 74 years with maxillary sinus cysts; 61 – from 28 to 71 years with acoustic neuromas; 56 – from 14 to 74 years with benign and malignant tumors of the larynx, nasal pharynx and paranasal sinuses. Conclusions. Pineal gland calcifications – can be considered as: mobile depot or cemetery of calcium; the result of an organ and/or a tumor-bearing organism protective reaction; a sign of a normal or decreased pineal gland function. The formation and growth of calcifications of the pineal gland and choroid plexuses of the lateral ventricles is associated with the growth and development of the body, benign and malignant tumors of the larynx, pharynx, paranasal sinuses and the auditory nerve (very likely, the tumors of other localizations as well). The formation and growth of calcifications of the pineal gland and choroid plexuses of the lateral ventricles indicates an increase of the heterogeneity of the human body tissues and organs with age and the acquisition of diseases.

Dose-related preventive and therapeutic effects of antioxidants-anticarcinogens on experimentally induced malignant tumors in Wistar rats

1997 ◽  
Vol 115 (1) ◽  
pp. 105-111 ◽  
Author(s):  
A. Evangelou ◽  
G. Kalpouzos ◽  
S. Karkabounas ◽  
R. Liasko ◽  
A. Nonni ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Malignant Tumors ◽  
Therapeutic Effects ◽  
Experimentally Induced

Experimental Amyloidosis Induced by Immune Complex

1971 ◽  
Vol 29 ◽  
pp. 582-583
Author(s):  
A. Kawaoi
Keyword(s):  
Immune Complex ◽  
Systemic Amyloidosis ◽  
Human Diseases ◽  
Experimental Amyloidosis ◽  
Freund’S Complete Adjuvant ◽  
Freund's Complete Adjuvant ◽  
Immunological Approach ◽  
Experimentally Induced

Numbers of immunological approach have been made to the amyloidosis through the variety of predisposing human diseases and the experimentally induced animals by the greater number of agents. The results suggest an important role of impaired immunity involving both humoral and cell-mediated aspects.Recently the author has succeeded in producing amyloidosis in the rabbits and mice by the injections of immune complex of heat denatured DNA.The aim of this report is to demonstrate the details of the ultrastructure of the amyloidosis induced by heterologous insoluble immune complex. Eleven of twelve mice, dd strain, subcutaneously injected twice a week with Freund's complete adjuvant and four of seven animals intraperitonially injected developed systemic amyloidosis two months later from the initial injections. The spleens were electron microscopically observed.

The application of electron microscopy to diagnosis in gynecologic neoplasms and tumor-like conditions

1984 ◽  
Vol 42 ◽  
pp. 102-105
Author(s):  
Lawrence M. Roth
Keyword(s):  
Electron Microscopy ◽  
Reproductive Tract ◽  
Malignant Tumors ◽  
Frozen Section ◽  
Cost Effective ◽  
Female Reproductive Tract ◽  
Ultrastructural Examination ◽  
Specific Diagnosis ◽  
Potential Value ◽  
Gynecologic Neoplasms

The female reproductive tract may be the site of a wide variety of benign and malignant tumors, as well as non-neoplastic tumor-like conditions, most of which can be diagnosed by light microscopic examination including special stains and more recently immunoperoxidase techniques. Nevertheless there are situations where ultrastructural examination can contribute substantially to an accurate and specific diagnosis. It is my opinion that electron microscopy can be of greatest benefit and is most cost effective when applied in conjunction with other methodologies. Thus, I have developed an approach which has proved useful for me and may have benefit for others. In cases where it is deemed of potential value, glutaraldehyde-fixed material is obtained at the time of frozen section or otherwise at operation. Coordination with the gynecologic oncologist is required in the latter situation. This material is processed and blocked and is available if a future need arises.

Ultrastructure of Cryptorchidism and Seminoma

1981 ◽  
Vol 39 ◽  
pp. 540-541
Author(s):  
Shirley Siew ◽  
Susan C. James
Keyword(s):  
Malignant Tumors ◽  
Frozen Section ◽  
Malignant Potential ◽  
Genetic Influences ◽  
Endocrine Gland ◽  
Medial Aspect ◽  
Left Testis ◽  
Bilateral Orchiectomy

Testicular maldescent is the most common endocrine gland abnormality, as 2.7% of mature neonates are cryptorchid. The significant complications are that there is a disturbance of normal maturation which results in diminished fertility and there is an increase in the malignant potential which is 35 times greater in the undescended than the descended testis. It is considered that genetic influences may be of etiological importance and recurrence has been described in some families. It is of interest, that the case reported here has 2 siblings who have also presented with cryptorchidism and malignant tumors.The propositus is 14 years old. He is well developed (described by some as obese) and shows normal secondary male characteristics except for an immature scrotum. Laparotomy showed both testes to be intraabdominal. A hard nodule (0.5cm) was palpated on the medial aspect of the left testis. Frozen section showed the presence of seminoma and bilateral orchiectomy was performed.

Hepatocyte ultrastructural alterations in perimetastatic areas

1996 ◽  
Vol 54 ◽  
pp. 768-769
Author(s):  
H. J. Finol ◽  
M. E. Correa ◽  
L.A. Sosa ◽  
A. Márquez ◽  
N.L. Díaz
Keyword(s):  
Malignant Tumor ◽  
Malignant Tumors ◽  
Surrounding Tissue ◽  
Ultrastructural Changes ◽  
Pancreas Carcinoma ◽  
Duct Carcinoma ◽  
Tissue Samples ◽  
Primary Malignant Tumor ◽  
Transmission Electron ◽  
Remote Sites

In classical oncological literature two mechanisms for tissue aggression in patients with cancer have been described. The first is the progressive invasion, infiltration and destruction of tissues surrounding primary malignant tumor or their metastases; the other includes alterations produced in remote sites that are not directly affected by any focus of disease, the so called paraneoplastic phenomenon. The non-invaded tissue which surrounds a primary malignant tumor or its metastases has been usually considered a normal tissue . In this work we describe the ultrastructural changes observed in hepatocytes located next to metastases from diverse malignant tumors.Hepatic biopsies were obtained surgically in patients with different malignant tumors which metatastized in liver. Biopsies included tumor mass, the zone of macroscopic contact between the tumor and the surrounding tissue, and the tissue adjacent to the tumor but outside the macroscopic area of infiltration. The patients (n = 5), 36–75 years old, presented different tumors including rhabdomyosarcoma, leiomyosarcoma, pancreas carcinoma, biliar duct carcinoma and colon carcinoma. Tissue samples were processed with routine techniques for transmission electron microscopy and observed in a Hitachi H-500 electron microscope.

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