Role of Homeodomain Transcription Factor IPF-1 in the Pathogenesis of Diabetes mellitus

2000 ◽  
pp. 197-208 ◽  
Author(s):  
J.F. Habener ◽  
D.A. Stoffers ◽  
D. Elahi ◽  
E.H. Hani ◽  
P. Froguel
Keyword(s):  
Diabetes Mellitus ◽  
Transcription Factor ◽  
Homeodomain Transcription Factor

Novel Homeodomain Transcription Factor Nkx2.2 in the Brain Tumor Development

2020 ◽  
Vol 20 (5) ◽  
pp. 335-340 ◽  
Author(s):  
Mubeena P.M. Mariyath ◽  
Mehdi H. Shahi ◽  
Shirin Farheen ◽  
Mohd Tayyab ◽  
Nabeela Khanam ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transcription Factor ◽  
Tumor Development ◽  
Normal Growth ◽  
Vital Role ◽  
Homeodomain Transcription Factor ◽  
Shh Pathway ◽  
Potential Biomarker

Background: Complex central nervous system (CNS) is made up of neuronal cells and glial cells. Cells of central nervous system are able to regenerate after injury and during repairing. Sonic hedgehog pathway initiated by Shh-N a glycoprotein plays vital role in CNS patterning growth, development and now tumorigenesis. Nkx2.2 homeodomain transcription factor is an effecter molecule, which is positively regulated by Shh during normal growth. Nkx2.2 is essential for V3 domain specification during neural tube patterning at embryonic stage. MBP + oligodendrocytes are differentiated from progenitor cells which express Olig2. Nx2.2 is co-expressed with Olig2 in oligodendrocytes and is essential for later stage of oligodendrocyte maturation. Objective: This review paper explores the potential role of Nkx2.2 transcription factor in glioblastoma development. Conclusion: Shh pathway plays a vital role in oligodendrocytes differentiation and Nkx2.2 transcription factor is essential for oligodendrocytes differentiation and maturation. Intriguingly, down regulation of Nkx2.2 transcription factor with aberrant Shh signaling pathway is reported in glioma samples. So here it is suggested that Nkx2.2 expression pattern could be used as a potential biomarker for the early diagnosis of glioma.

scholarly journals S08-10 The role of homeodomain transcription factor HNF1B in nephrogenesis

2009 ◽  
Vol 126 ◽  
pp. S34
Author(s):  
Gerhart U. Ryffel ◽  
Magdalena Roose ◽  
Kathrin Sauert ◽  
Christiane Drews ◽  
Christoph Waldner
Keyword(s):  
Transcription Factor ◽  
Homeodomain Transcription Factor

scholarly journals Role of homeodomain transcription factor Six1 in olfactory sensory neuron development

2006 ◽  
Vol 295 (1) ◽  
pp. 408
Author(s):  
Keiko Ikeda ◽  
Zen-ichi Ando ◽  
Shigeo Oowakara ◽  
Kiyoshi Kawakami
Keyword(s):  
Transcription Factor ◽  
Sensory Neuron ◽  
Olfactory Sensory Neuron ◽  
Neuron Development ◽  
Homeodomain Transcription Factor

Possible Role of Prep1 Homeodomain Transcription Factor in Cardiac Mesenchymal Stromal Cells

2021 ◽  
Vol 55 (6) ◽  
pp. 847-853
Author(s):  
Y. S. Stafeev ◽  
E. K. Shevchenko ◽  
M. A. Boldireva ◽  
D. N. Penkov
Keyword(s):  
Transcription Factor ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Homeodomain Transcription Factor

scholarly journals Role of the Homeodomain Transcription Factor Bapx1 in Mouse Distal Stomach Development

2009 ◽  
Vol 136 (5) ◽  
pp. 1701-1710 ◽  
Author(s):  
Michael P. Verzi ◽  
Monique N. Stanfel ◽  
Kelvin A. Moses ◽  
Byeong-Moo Kim ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Distal Stomach ◽  
Homeodomain Transcription Factor

AMPK AND SIRT1 IN THE REGULATION OF LIVER METABOLISM IN OBESE PATIENTS WITH TYPE 2 DIABETES MELLITUS

2021 ◽  
Author(s):  
Мария Александровна Вульф ◽  
Дарья Александровна Скуратовская ◽  
Александра Андреевна Комар ◽  
Лариса Сергеевна Литвинова
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Transcription Factor ◽  
Carbohydrate Metabolism ◽  
Liver Metabolism ◽  
Protective Role ◽  
Obese Patients

У больных ожирением выявлены взаимосвязи основных регуляторов метаболизма (AMPK и SITRT1) в печени с нарушениями со стороны липидного и углеводного обменов. Установлена протекторная роль SIRT1 в подавлении экспрессии транскрипционного фактора NF-kB в печени, способствующего переходу стеатоза в стеатогепатит. In obese patients, interrelations of the main regulators of metabolism (AMPK and SITRT1) in the liver with lipid and carbohydrate metabolism disorders were revealed. The protective role of SIRT1 in suppressing the expression of the transcription factor NF-kB in the liver, which promotes the transition of steatosis to steatohepatitis, has been established.

The role of Phox2b in synchronizing pan-neuronal and type-specific aspects of neurogenesis

Development ◽  
2002 ◽  
Vol 129 (22) ◽  
pp. 5241-5253
Author(s):  
Véronique Dubreuil ◽  
Marie-Rose Hirsch ◽  
Caroline Jouve ◽  
Jean-François Brunet ◽  
Christo Goridis
Keyword(s):  
Nervous System ◽  
Transcription Factor ◽  
Neuronal Differentiation ◽  
Genetic Interactions ◽  
Homeodomain Transcription Factor ◽  
Dual Action ◽  
Separate Pathway ◽  
Neuronal Subtype ◽  
Necessary And Sufficient

Within the developing vertebrate nervous system, specific subclasses of neurons are produced in vastly different numbers at defined times and locations. This implies the concomitant activation of a program that controls pan-neuronal differentiation and of a program that specifies neuronal subtype identity, but how these programs are coordinated in time and space is not well understood. Our previous loss- and gain-of-function studies have defined Phox2b as a homeodomain transcription factor that coordinately regulates generic and type-specific neuronal properties. It is necessary and sufficient to impose differentiation towards a branchio- and viscero-motoneuronal phenotype and at the same time promotes generic neuronal differentiation. We have examined the underlying genetic interactions. We show thatPhox2b has a dual action on pan-neuronal differentiation. It upregulates the expression of proneural genes (Ngn2) when expressed alone and upregulates the expression of Mash1 when expressed in combination with Nkx2.2. By a separate pathway, Phox2brepresses expression of the inhibitors of neurogenesis Hes5 andId2. The role of Phox2b in the specification of neuronal subtype identity appears to depend in part on its capacity to act as a patterning gene in the progenitor domain. Phox2b misexpression represses the Pax6 and Olig2 genes, which should inhibit a branchiomotor fate, and induces Nkx6.1 and Nkx6.2, which are expressed in branchiomotor progenitors. We further show that Phox2b behaves like a transcriptional activator in the promotion of both, generic neuronal differentiation and expression of the motoneuronal marker Islet1. These results provide insights into the mechanisms by which a homeodomain transcription factor through interaction with other factors controls both generic and type-specific features of neuronal differentiation.

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