Mapping Genes Regulating Lymphocyte Function: Correlations with Autoimmunity?

1999 ◽  
pp. 226-246
Author(s):  
D. Lo ◽  
N. Aftahi ◽  
C. Reilly ◽  
H. Neal ◽  
B. Sim ◽  
...  
Keyword(s):  
Lymphocyte Function

Lymphocyte function in rheumatic disorders

1975 ◽  
Vol 135 (10) ◽  
pp. 1324-1328 ◽  
Author(s):  
J. H. Vaughan
Keyword(s):  
Lymphocyte Function

Influence of chronic hyperprolactinemia on lymphocyte function in patients with prolactinoma

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
K Reschke ◽  
M Kopp ◽  
A Ittenson ◽  
S Ansorge ◽  
H Lehnert
Keyword(s):  
Lymphocyte Function

THE EFFECT OF SUBACUTE INTOXICATION WITH ETHYLENE CHLOROHYDRIN ON IMMUNE RESPONSES, TH1 AND TH2 LYMPHOCYTE FUNCTION AND CYTOKINE LEVELS IN RATS BLOOD

2017 ◽  
pp. 27-30
Author(s):  
P. F. Zabrodskii ◽  
V. V. Maslyakov ◽  
M. S. Gromov
Keyword(s):  
Immune Responses ◽  
Inflammatory Cytokine ◽  
Albino Rats ◽  
Lymphocyte Function ◽  
Ethylene Chlorohydrin ◽  
Immunoregulatory Cytokines ◽  
Cytokine Levels ◽  
Th1 And Th2 Lymphocytes ◽  
Cellular Immune ◽  
Th1 And Th2

In experiments on outbred albino rats, it was established that subacute intoxication with ethylene chlorohydrin (0.2 LD50 daily for 4 days) causes a decrease in Th1 and Th2 lymphocytes function to the same extent, diminishes parameters of humoral and cellular immune responses and the content of immunoregulatory cytokines IFN- , IL-2, IL-4 in blood, increases concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10.

scholarly journals Oxidative Stress Compromises Lymphocyte Function in Neonatal Dairy Calves

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 255
Author(s):  
Wilmer Cuervo ◽  
Lorraine M. Sordillo ◽  
Angel Abuelo
Keyword(s):  
Oxidative Stress ◽  
Immune Responses ◽  
Immune Cell ◽  
Lymphocyte Activation ◽  
Dairy Calves ◽  
Lymphocyte Function ◽  
Newborn Calves ◽  
Ifn Γ ◽  
The Impact

Dairy calves are unable to mount an effective immune response during their first weeks of life, which contributes to increased disease susceptibility during this period. Oxidative stress (OS) diminishes the immune cell capabilities of humans and adult cows, and dairy calves also experience OS during their first month of life. However, the impact that OS may have on neonatal calf immunity remains unexplored. Thus, we aimed to evaluate the impact of OS on newborn calf lymphocyte functions. For this, we conducted two experiments. First, we assessed the association of OS status throughout the first month of age and the circulating concentrations of the cytokines interferon-gamma (IFN-γ) and interleukin (IL) 4, as well as the expression of cytokine-encoding genes IFNG, IL2, IL4, and IL10 in peripheral mononuclear blood cells (PBMCs) of 12 calves. Subsequently, we isolated PBMCs from another 6 neonatal calves to investigate in vitro the effect of OS on immune responses in terms of activation of lymphocytes, cytokine expression, and antibody production following stimulation with phorbol 12-myristate 13-acetate or bovine herpesvirus-1. The results were compared statistically through mixed models. Calves exposed to high OS status in their first month of age showed higher concentrations of IL-4 and expression of IL4 and IL10 and lower concentrations of IFN-γ and expression of IFNG and IL2 than calves exposed to lower OS. In vitro, OS reduced lymphocyte activation, production of antibodies, and protein and gene expression of key cytokines. Collectively, our results demonstrate that OS can compromise some immune responses of newborn calves. Hence, further studies are needed to explore the mechanisms of how OS affects the different lymphocyte subsets and the potential of ameliorating OS in newborn calves as a strategy to augment the functional capacity of calf immune cells, as well as enhance calves’ resistance to infections.

Lymphocyte function in experimental African trypanosomiasis

1981 ◽  
Vol 63 (1) ◽  
pp. 210-215 ◽  
Author(s):  
John M. Mansfield ◽  
Rita F. Levine ◽  
Walla L. Dempsey ◽  
Sam R. Wellhausen ◽  
Carl T. Hansen
Keyword(s):  
Lymphocyte Function ◽  
African Trypanosomiasis

OP0195 Genetic and Pharmacologic Inhibition of MST1 Blocks Lymphocyte Function and Protects Against Inflammation and Autoimmunity

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A118.3-A118
Author(s):  
T. Oravecz ◽  
W. C. Chang ◽  
K. G. Jhaver ◽  
A. Al-Shami ◽  
T. C. Jessop ◽  
...  
Keyword(s):  
Lymphocyte Function ◽  
Pharmacologic Inhibition
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