New Approaches in Molecular Diagnostics of Human Infections Caused by Bartonella henselae

1998 ◽  
pp. 130-142
Author(s):  
D. Goldenberger ◽  
M. Altwegg
Keyword(s):  
Molecular Diagnostics ◽  
Bartonella Henselae ◽  
New Approaches ◽  
Human Infections

scholarly journals Molecular Diagnosis of Abdominal Armillifer grandis Pentastomiasis in the Democratic Republic of Congo

2015 ◽  
Vol 53 (7) ◽  
pp. 2362-2364 ◽  
Author(s):  
Dennis Tappe ◽  
Mihály Sulyok ◽  
Lajos Rózsa ◽  
Birgit Muntau ◽  
Alexandra Haeupler ◽  
...  
Keyword(s):  
Rural Area ◽  
Molecular Diagnostics ◽  
Morphological Study ◽  
Parasite Species ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Content Type ◽  
Remote Areas ◽  
Human Infections ◽  
The Tropics

Pentastomiasis is an emerging snake-borne parasitic zoonosis in the tropics. We describe a molecular and morphological study to diagnose a cluster of asymptomatic abdominal human infections caused byArmillifer grandis.The findings may indicate a silent epidemic in a rural area where severe symptomatic ocular cases with the same parasite species have recently surfaced. Molecular diagnostics are of increasing importance when patient material from remote areas cannot be thoroughly examined locally for logistic reasons.

scholarly journals Implementation of scanning probe microscopy for the solution of molecular diagnostics tasks

2014 ◽  
Vol 60 (5) ◽  
pp. 543-547
Author(s):  
E.V. Dubrovin ◽  
G.V. Presnova ◽  
M.Yu. Rubtsova ◽  
V.G. Grigorenko ◽  
A.I. Ivanin ◽  
...  
Keyword(s):  
Molecular Diagnostics ◽  
Scanning Probe Microscopy ◽  
Scanning Probe ◽  
Automatic Calculation ◽  
Probe Microscopy ◽  
New Approaches ◽  
Specific Hybridization

We present new approaches to improve the efficiency of DNA by scanning probe microscopy using a highly specific hybridization on affine surfaces and nanostructures of gold as a labels. Scanning probe microscopy allows to register of individual acts of hybridization by the detection of gold labels on the surface affinity followed by automatic calculation of the total.

The Trick of the Hedgehog: Case Report and Short Review About Archaeopsylla erinacei (Siphonaptera: Pulicidae) in Human Health

2019 ◽  
Vol 57 (1) ◽  
pp. 318-323 ◽  
Author(s):  
Valentin Greigert ◽  
Julie Brunet ◽  
Basma Ouarti ◽  
Maureen Laroche ◽  
Alexander W Pfaff ◽  
...  
Keyword(s):  
Human Health ◽  
Homo Sapiens ◽  
Bartonella Henselae ◽  
Short Review ◽  
Rickettsia Felis ◽  
Key Characteristics ◽  
Human Pathology ◽  
Archaeopsylla Erinacei ◽  
Human Infections ◽  
Hematophagous Arthropods

Abstract Fleas are ectoparasites of various animals, including Homo sapiens Linnaeus, 1758 (Primates: Hominidae). Among the species relevant to the human health field, either due to their dermatopathological potential or because of their role as vectors of microorganisms responsible for infectious diseases, such as plague or murine typhus, are the human flea, oriental rat flea, closely related cat and dog fleas, and chigoe flea. However, other species can accidentally infest humans. We have herein reported two unusual cases of humans infested and bitten by Archaeopsylla erinacei, the hedgehog flea. This species has been identified using stereomicroscopy, on the base of key characteristics. Furthermore, a brief literature review has revealed that hedgehog fleas could carry human-infectious agents, such as Rickettsia felis Bouyer et al. 2001 (Rickettsiales: Rickettsiaceae) or Bartonella henselae Regnery et al.1992 (Rhizobiales: Bartonellaceae). Using molecular biology, we thus tested nine A. erinacei specimens taken from these patients, for several bacteria species commonly associated with hematophagous arthropods, implicated in human pathology. However, all our samples were proven negative. The role of A. erinacei in human epidemiology has never been evaluated to date. This report sought to remind us that these fleas can be accidental parasites in humans. In addition, recent findings pertaining to bacteria of medical interest that are present in these insects should be brought to the fore, given that the question of their role as vectors in human infections remains unanswered and deserves further investigation.

scholarly journals New Approaches to Sepsis: Molecular Diagnostics and Biomarkers

2012 ◽  
Vol 25 (4) ◽  
pp. 609-634 ◽  
Author(s):  
K. Reinhart ◽  
M. Bauer ◽  
N. C. Riedemann ◽  
C. S. Hartog
Keyword(s):  
Molecular Diagnostics ◽  
New Approaches

New Approaches to Molecular Diagnostics of Prenatal Pathology

2011 ◽  
Vol 151 (5) ◽  
pp. 567-570 ◽  
Author(s):  
T. N. Pogorelova ◽  
V. I. Orlov ◽  
V. O. Gunko
Keyword(s):  
Molecular Diagnostics ◽  
New Approaches

Beyond autism: Challenging unexamined assumptions about social motivation in typical development

2019 ◽  
Vol 42 ◽  
Author(s):  
Karen Bartsch ◽  
David Estes
Keyword(s):  
Social Interest ◽  
Social Motivation ◽  
Typical Development ◽  
Typically Developing ◽  
New Approaches

Abstract In challenging the assumption of autistic social uninterest, Jaswal & Akhtar have opened the door to scrutinizing similar unexamined assumptions embedded in other literatures, such as those on children's typically developing behaviors regarding others’ minds and morals. Extending skeptical analysis to other areas may reveal new approaches for evaluating competing claims regarding social interest in autistic individuals.

The zoonotic potential of bat-borne coronaviruses

2020 ◽  
Vol 4 (4) ◽  
pp. 365-381
Author(s):  
Ny Anjara Fifi Ravelomanantsoa ◽  
Sarah Guth ◽  
Angelo Andrianiaina ◽  
Santino Andry ◽  
Anecia Gentles ◽  
...  
Keyword(s):  
Genetic Material ◽  
Field Research ◽  
Sympatric Species ◽  
Animal Origin ◽  
Mammalian Host ◽  
Past Century ◽  
The Past ◽  
Novel Host ◽  
Horseshoe Bat ◽  
Human Infections

Seven zoonoses — human infections of animal origin — have emerged from the Coronaviridae family in the past century, including three viruses responsible for significant human mortality (SARS-CoV, MERS-CoV, and SARS-CoV-2) in the past twenty years alone. These three viruses, in addition to two older CoV zoonoses (HCoV-229E and HCoV-NL63) are believed to be originally derived from wild bat reservoir species. We review the molecular biology of the bat-derived Alpha- and Betacoronavirus genera, highlighting features that contribute to their potential for cross-species emergence, including the use of well-conserved mammalian host cell machinery for cell entry and a unique capacity for adaptation to novel host environments after host switching. The adaptive capacity of coronaviruses largely results from their large genomes, which reduce the risk of deleterious mutational errors and facilitate range-expanding recombination events by offering heightened redundancy in essential genetic material. Large CoV genomes are made possible by the unique proofreading capacity encoded for their RNA-dependent polymerase. We find that bat-borne SARS-related coronaviruses in the subgenus Sarbecovirus, the source clade for SARS-CoV and SARS-CoV-2, present a particularly poignant pandemic threat, due to the extraordinary viral genetic diversity represented among several sympatric species of their horseshoe bat hosts. To date, Sarbecovirus surveillance has been almost entirely restricted to China. More vigorous field research efforts tracking the circulation of Sarbecoviruses specifically and Betacoronaviruses more generally is needed across a broader global range if we are to avoid future repeats of the COVID-19 pandemic.

Sign in / Sign up

Export Citation Format

Share Document