Renal Biopsy Findings and Clinical Course

2001 ◽  
pp. 97-105
Author(s):  
S.-i. Nishi ◽  
M. Ueno ◽  
F. Gejyo
Keyword(s):  
Renal Biopsy ◽  
Clinical Course

scholarly journals Difficult Renal Pathological Classification in a Case of Pediatric Nephrotic Syndrome

2017 ◽  
Vol 7 (3) ◽  
pp. 161-166
Author(s):  
Hiroshi Yamaguchi ◽  
Atsutoshi Shiratori ◽  
Taku Nakagawa ◽  
Kyoko Kanda ◽  
Shigeo Hara ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Complete Remission ◽  
Renal Biopsy ◽  
Clinical Course ◽  
Minimal Change ◽  
Albumin Infusion ◽  
Dense Deposits ◽  
Old Japanese ◽  
Foot Process ◽  
The Impact

The underlying histopathology is very important in determining patient management, as the histopathology usually has direct repercussions on the treatment response and clinical course. However, the impact of the method used to assess renal biopsies, i.e., light microscopy (LM), immunofluorescence (IF), and electron microscopy (EM), on the occurrence of a difficult biopsy classification in the native kidneys of pediatric nephrotic patients is unknown. A 12-month-old Japanese boy was diagnosed with nephrotic syndrome (NS); he was administered prednisolone (60 mg/m2/day), and a continuous albumin infusion was started. A renal biopsy using LM revealed minimal change. However, an IF study showed granular staining for immunoglobulin G along the glomerular basement membrane. Therefore, he was diagnosed with membranous nephropathy (MN). As his proteinuria was so severe, we started immunosuppressant therapy and continued the albumin infusion for more than 2 months. However, he did not attain complete remission. A month later, EM examination of his renal biopsy showed extensive foot process fusion without electron-dense deposits. Although the result of the IF study suggested MN, the results of the LM and EM studies indicated minimal change. We finally diagnosed the patient with minimal change NS, in consideration of his clinical condition and course. Because of the failure of previous treatments, pulse steroid therapy was started. After five rounds of therapy the patient attained complete remission. A difficult renal biopsy finding classification, dependent on the diagnostic method used, might occur in the native kidneys of pediatric nephrotic patients. Therefore, a diagnosis should be made after considering all renal biopsy findings and the clinical course.

scholarly journals Protracted Clinical Course of Postinfectious Glomerulonephritis in a Previously Healthy Child

2016 ◽  
Vol 6 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Camilla Grøndahl ◽  
Søren Rittig ◽  
Johan Vestergaard Povlsen ◽  
Kostantinos Kamperis
Keyword(s):  
Respiratory Tract ◽  
Renal Biopsy ◽  
Healthy Child ◽  
Clinical Course ◽  
Skin Infections ◽  
Upper Respiratory Tract ◽  
Postinfectious Glomerulonephritis ◽  
Upper Respiratory ◽  
Gross Haematuria ◽  
Nephrotic Range Proteinuria

Acute postinfectious glomerulonephritis (PIGN) affects children typically after upper respiratory tract or skin infections with streptococci but can complicate the course of other infections. In children, it is generally a self-limiting disease with excellent prognosis. This paper reports a previously healthy 4-year-old boy who experienced a protracted course of PIGN with persisting episodes of gross haematuria, proteinuria, decreased complement C3c levels but normal P-creatinine levels. Due to the protracted course and the nephrotic-range proteinuria, a renal biopsy was performed 6 months after the initial presentation and the overall pathology was consistent with acute endocapillary glomerulonephritis.

The renal scan as an aid in percutaneous renal biopsy

JAMA ◽  
1966 ◽  
Vol 195 (11) ◽  
pp. 913-915 ◽  
Author(s):  
S. Baum
Keyword(s):  
Renal Biopsy ◽  
Percutaneous Renal Biopsy ◽  
Renal Scan

74: How Septic is Urosepsis? Treatment and Clinical Course of Infected Hydronephrosis

2005 ◽  
Vol 173 (4S) ◽  
pp. 21-21
Author(s):  
Frank Christoph ◽  
Steffen Weikert ◽  
Markus Müller ◽  
Kurt Miller
Keyword(s):  
Clinical Course ◽  
Infected Hydronephrosis
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