Pathogenesis of Renal Cell Adenomas and Carcinomas in Animal Models

1999 ◽  
pp. 99-125 ◽  
Author(s):  
P. Bannasch ◽  
H. Zerban
Keyword(s):  
Animal Models ◽  
Renal Cell

scholarly journals Does Fingolimod have anticancer effects? A meta-analysis and systematic review based on experimental animal models of various cancers

2020 ◽  
Author(s):  
Yuze Ge ◽  
Ping Zhou ◽  
Lu Kong
Keyword(s):  
Renal Cell Carcinoma ◽  
Animal Models ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Meta Analysis ◽  
Signal Pathways ◽  
Bias Analysis ◽  
Immunodeficient Mice ◽  
Anticancer Effects

Abstract Background: Numerous studies have explored the anticancer effect of FTY720 (Fingolimod) in animal models, a sphingosine-1-phosphate (S1P) receptor antagonist and an immunosuppressant, but little clinical evidence guides the use of FTY720 in cancer patients.Methods: Strictly, only related published articles about the treatment with FTY720 for various cancers in vivo from January 1998 to January 2020 were selected from PubMed, Web of Science, Ovid, Embase, CNKI and Cochrane databases, and which were qualified. We acquired agreement through discussion. Then, we conducted meta-analysis, subgroups analysis, publication bias analysis and sensitivity analysis based on selected studies. In the last two sections, we summaried and compared side effects, drug combination effects and molecular pathways from selected studies.Results: In the 31 articles included from 2002 to 2019, FTY720 was found to reduce tumor volume (SMD =-2.58, 95% CI: -3.42, -1.75, Z = 6.09, P = 0.000), tumor weight (SMD = -3.69, 95% CI: -5.17, -2.21, Z = 4.88, P = 0.000) and body weight (SMD = -0.86, 95% CI: -1.61, -0.11, Z = 2.23, P = 0.025) in 14 types of cancer. Relevant frequent signal pathways include the Akt pathway, S1PRs-Caspase pathway and the STAT3-PP2A pathway. FTY720 has significant independent or in combination anticancer effects and a lower toxicity in renal cell carcinoma and neuroblastoma mice models. However, it should be noted that FTY720 achieved a significant therapeutic effect in immunodeficient mice, not in immunecompetent mice. Also, the dosage-safety of FTY720 alone in clinical use is a noteworthy issue. In mouse models, the mechanism of the FTY720 treatment of tumors lies in inducing the tumor cells apoptosis through important signaling moleculars.Conclusions: FTY720 alone or in combination exerted significant anti-tumor effects for neuroblastoma and renal cell carcinoma, however not for melanoma. Due to insufficient evidence, more specific studies of FTY720 only and in combination included in immunity, inflammation and melanoma should be carried out in the future preclinical and clinical studies.

scholarly journals Successful Combination of Sunitinib and Girentuximab in Two Renal Cell Carcinoma Animal Models: A Rationale for Combination Treatment of Patients with Advanced RCC

Neoplasia ◽  
2015 ◽  
Vol 17 (2) ◽  
pp. 215-224 ◽  
Author(s):  
Jeannette C. Oosterwijk-Wakka ◽  
Mirjam C.A. de Weijert ◽  
Gerben M. Franssen ◽  
William P.J. Leenders ◽  
Jeroen A.W.M. van der Laak ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Animal Models ◽  
Cell Carcinoma ◽  
Combination Treatment ◽  
Renal Cell

Use of animal models in diagnosis and treatment of renal cell carcinoma

1991 ◽  
Vol 9 (4) ◽  
pp. 192-197 ◽  
Author(s):  
R. J. A. van Moorselaar ◽  
J. A. Schalken ◽  
G. O. N. Oosterhof ◽  
F. M. J. Debruyne
Keyword(s):  
Renal Cell Carcinoma ◽  
Animal Models ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Diagnosis And Treatment

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

INTRINSIC RENAL CELL DERIVED IL‐12 IS AN EFFECTOR OF RENAL GLOMERULAR INJURY IN CRESCENTIC GLOMERULONEPHRITIS

Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. A98-A98
Author(s):  
Timoshanko Jr ◽  
Kitching Ar ◽  
Holdsworth Sr ◽  
Tipping PG.
Keyword(s):  
Renal Cell ◽  
Crescentic Glomerulonephritis ◽  
Glomerular Injury

1253: Different Survival in PT3A Renal Cell Carcinoma with Sinus Fat Invasion or Perinephric Fat Invasion

2007 ◽  
Vol 177 (4S) ◽  
pp. 413-413
Author(s):  
Marco Roscigno ◽  
Roberto Bertini ◽  
Cesare Cozzarini ◽  
Alessandra Pasta ◽  
Mattia Sangalli ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Perinephric Fat
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