Osmoregulation of Liver Cell Function: Signalling, Osmolytes and Cell Heterogeneity

1998 ◽  
pp. 185-204 ◽  
Author(s):  
D. H�ussinger
Keyword(s):  
Liver Cell ◽  
Cell Function ◽  
Cell Heterogeneity

Liver cell hydration and integrin signaling

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Michele Bonus ◽  
Dieter Häussinger ◽  
Holger Gohlke
Keyword(s):  
Cell Volume ◽  
Liver Cell ◽  
Cell Function ◽  
The Other ◽  
Signaling Cascades ◽  
Integrin Signaling ◽  
Volume Changes ◽  
The One ◽  
And Oxidative Stress

Abstract Liver cell hydration (cell volume) is dynamic and can change within minutes under the influence of hormones, nutrients, and oxidative stress. Such volume changes were identified as a novel and important modulator of cell function. It provides an early example for the interaction between a physical parameter (cell volume) on the one hand and metabolism, transport, and gene expression on the other. Such events involve mechanotransduction (osmosensing) which triggers signaling cascades towards liver function (osmosignaling). This article reviews our own work on this topic with emphasis on the role of β1 integrins as (osmo-)mechanosensors in the liver, but also on their role in bile acid signaling.

Liver Cell Heterogeneity: Functions of Non-Parenchymal Cells

Enzyme ◽  
1992 ◽  
Vol 46 (1-3) ◽  
pp. 155-168 ◽  
Author(s):  
Luc Bouwens ◽  
Pieter De Bleser ◽  
Karin Vanderkerken ◽  
Bert Geerts ◽  
Eddie Wisse
Keyword(s):  
Liver Cell ◽  
Cell Heterogeneity ◽  
Parenchymal Cells

Liver Cell Heterogeneity in Biotransformation of Carcinogenic Polycyclic Hydrocarbons

1988 ◽  
pp. 265-272
Author(s):  
A. Schlenker ◽  
S. A. E. Finch ◽  
W. Kühnle ◽  
J. Sidhu ◽  
A. Stier
Keyword(s):  
Liver Cell ◽  
Cell Heterogeneity ◽  
Polycyclic Hydrocarbons

Zonal Liver Cell Heterogeneity

Enzyme ◽  
1992 ◽  
Vol 46 (1-3) ◽  
pp. I-III
Keyword(s):  
Liver Cell ◽  
Cell Heterogeneity
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