Comparison of the Effectiveness of Scanning Laser Polarimetry and Optical Coherence Tomography for Estimating Optic Nerve Fibre Layer Thickness in Patients with Glaucoma

2002 ◽  
Vol 216 (3) ◽  
pp. 168-174 ◽  
Author(s):  
Mieko Furuichi ◽  
Kenji Kashiwagi ◽  
Yoshiharu Furuichi ◽  
Shigeo Tsukahara
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Scanning Laser ◽  
Optical Coherence ◽  
Scanning Laser Polarimetry ◽  
Laser Polarimetry ◽  
Optic Nerve Fibre ◽  
Nerve Fibre Layer

scholarly journals Retinal nerve fibre layer thickness measurements in childhood glaucoma: the role of scanning laser polarimetry and optical coherence tomography

2021 ◽  
Author(s):  
Mael Lever ◽  
Christian Halfwassen ◽  
Jan Darius Unterlauft ◽  
Nikolaos E. Bechrakis ◽  
Anke Manthey ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Scanning Laser ◽  
Optical Coherence ◽  
Scanning Laser Polarimetry ◽  
Laser Polarimetry ◽  
Nerve Fibre Layer ◽  
Thickness Measurements ◽  
Inferior Quadrant

Abstract Purpose A central diagnostic tool in adult glaucoma is the peripapillary retinal nerve fibre layer (pRNFL) thickness. It can be assessed by scanning laser polarimetry (SLP) or optical coherence tomography (OCT). However, studies investigating the relevance of pRNFL measurements in children are rare. This study aims to compare the glaucoma diagnosing ability of SLP and OCT pRNFL thickness measurements in a paediatric population. Methods This retrospective study included 105 children (glaucoma: 22 (21.0%); healthy glaucoma suspects: 83 (79.0%)) aged 4–18 years, examined with SLP (GDxPro/ECC, Carl Zeiss Meditec) and spectral-domain OCT (SPECTRALIS®, Heidelberg Engineering). The thickness of pRNFL sectors was compared between diseased and healthy participants. Areas under the receiver-operating characteristic curves (AUC) and logistic regression results were used to compare the glaucoma discriminative capacity between SLP and OCT measurements. Results Using OCT, pRNFL thickness was decreased in the superior, nasal, and inferior quadrants of glaucoma patients compared to healthy controls (P < 0.001, each). With SLP, such a difference was only observed in the inferior quadrant (P = 0.011). A correlation between glaucoma diagnosis and OCT-measured pRNFL thickness was found in all quadrants (P < 0.001) other than the temporal. With SLP, a correlation was found for the total average thickness (P = 0.037) and inferior quadrant (P = 0.0019). Finally, the AUCs of OCT measurements were markedly higher than those of SLP (e.g., inferior quadrant: OCT 0.83, SLP 0.68). Conclusion pRNFL thickness measurements using both OCT and SLP, correlate notably with the presence of glaucoma. In general, the diagnostic performance of pRNFL thickness measurements seems higher for OCT than for SLP. Thus, pRNFL thickness measurements could provide important information, complementing conventional clinical and functional parameters in the diagnostic process of paediatric glaucoma.

Detecting optic nerve head swelling on ultrasound and optical coherence tomography in children and young people: an observational study

2017 ◽  
Vol 102 (3) ◽  
pp. 318-322 ◽  
Author(s):  
Annegret Hella Dahlmann-Noor ◽  
Gillian W Adams ◽  
Moritz Claudius Daniel ◽  
Alison Davis ◽  
Joanne Hancox ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Young People ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Diagnostic Workup ◽  
Optical Coherence ◽  
Children And Young People ◽  
Fibre Layer ◽  
Nerve Fibre Layer

BackgroundFollowing high-profile cases, referrals for evaluation of ‘suspicious optic discs’ to eye clinics in the UK have sharply increased, asking ophthalmologists to reliably distinguish between true and pseudopapilloedema. Optic nerve sheath dilatation (ONSD) on ocular ultrasound (US) is considered a reliable sign of true papilloedema, but this test is not widely available. Recently, anterior bowing of Bruch’s membrane (BM) and increased retinal nerve fibre layer thickness on optical coherence tomography (OCT) have emerged as indicators of intracranial hypertension, and OCT is widely available. We aimed to evaluate safety and efficacy of the diagnostic workup in our service, with particular emphasis of diagnostic reliability of US and OCT.MethodsRetrospective service evaluation/cohort study of children and young people younger than 16 years investigated for ‘suspicious discs’ over a 7-month period in 2016 at a single eye care provider in London, UK. 61 children and young people underwent clinical assessment, US scan and OCT.ResultsOf 61 cases, 3 had intracranial pathology. At presentation, only one had ONSD on US and anterior bowing of BM on OCT. Increased nerve fibre layer thickness in at least one of three relevant sectors was observed in two cases. All three cases of intracranial pathology, however, had significant points in their presenting or medical history.ConclusionOphthalmologists and optometrists must not rely on funduscopy and ocular imaging when assessing a child for possible intracranial disease; history and basic neurological assessment are critical in the diagnostic workup.

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