Changing Epidemiology of Bacterial Infection in Neutropenic Patients with Cancer

1999 ◽  
pp. 1-9
Author(s):  
J. Carratalà ◽  
F. Gudiol
Keyword(s):  
Bacterial Infection ◽  
Patients With Cancer ◽  
Neutropenic Patients

Neutropenic diets to prevent cancer infections: updated systematic review and meta-analysis

2019 ◽  
pp. bmjspcare-2018-001742 ◽  
Author(s):  
Mohamad Bassam Sonbol ◽  
Tania Jain ◽  
Belal Firwana ◽  
Talal Hilal ◽  
Thomas Deleon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Cell Transplant ◽  
Regular Diet ◽  
Patients With Cancer ◽  
Transplant Patients ◽  
Haematopoietic Cell ◽  
Significant Difference ◽  
Neutropenic Patients ◽  
Meta Analyses

IntroductionMultiple studies have questioned the benefit of neutropenic diets in decreasing infections in patients with cancer, but recent surveys showed that such diets are still prescribed. In this study, we sought to evaluate the effectiveness of neutropenic diet in decreasing infection and mortality in neutropenic patients with cancer with neutropenia. This review is an update of a previously published systematic review.Materials and methodsWe searched different databases to identify comparative studies that investigated the effect of neutropenic diet compared with regular diet in neutropenic adults and children with cancer. We conducted random‐effects meta‐analyses using the Der‐Simonian and Laird method to pool treatment effects from included studies. Outcomes of interest were mortality, bacteremia/fungemia, major infections, quality of life, and the composite outcome for neutropenic fever and/or infection.ResultsWe included six studies (five randomised) with 1116 patients, with 772 (69.1%) having underwent haematopoietic cell transplant. There was no statistically significant difference between neutropenic diet and regular diet in the rates of major infections (relative risk [RR] 1.16; 95% CI 0.94 to 1.42) or bacteremia/fungemia (RR 0.96; 95% CI 0.60 to 1.53). In haematopoietic cell transplant patients, neutropenic diet was associated with a slightly higher risk of infections (RR 1.25; 95% CI 1.02 to 1.54). No difference in mortality was seen between neutropenic diet and regular diet (RR 1.08, 95% CI 0.78 to 1.50).ConclusionThere is currently no evidence to support the use of neutropenic diet or other food restrictions in neutropenic patients with cancer. Patients and clinicians should continue to follow the safe food-handling guidelines as recommended by the U.S. Food and Drug Administration.

scholarly journals Efficacy and Safety of Linezolid Compared with Vancomycin in a Randomized, Double-Blind Study of Febrile Neutropenic Patients with Cancer

2006 ◽  
Vol 42 (5) ◽  
pp. 597-607 ◽  
Author(s):  
B. Jaksic ◽  
G. Martinelli ◽  
J. P. Oteyza ◽  
C. S. Hartman ◽  
L. B. Leonard ◽  
...  
Keyword(s):  
Blind Study ◽  
Double Blind Study ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Patients With Cancer ◽  
Neutropenic Patients
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