Sign Language Activated the Auditory Cortex of a Congenitally Deaf Subject: Revealed by Positron Emission Tomography

2000 ◽  
pp. 60-62
Author(s):  
H. Nishimura ◽  
K. Doi ◽  
T. Iwaki ◽  
K. Hashikawa ◽  
T. Nishimura ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Auditory Cortex ◽  
Sign Language ◽  
Emission Tomography ◽  
Positron Emission ◽  
Deaf Subject

scholarly journals Regulation of Noise-Induced Loss of Serotonin Transporters with Resveratrol in a Rat Model Using 4-[18F]-ADAM/Small-Animal Positron Emission Tomography

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1344 ◽  
Author(s):  
I-Hsun Li ◽  
Jui-Hu Shih ◽  
Yun-Tin Jhao ◽  
Hsin-Chien Chen ◽  
Chuang-Hsin Chiu ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Auditory Cortex ◽  
Auditory System ◽  
Noise Exposure ◽  
Afferent Fiber ◽  
Serotonergic System ◽  
Emission Tomography ◽  
Serotonin Transporters ◽  
Positron Emission ◽  
Brainstem Response

Serotonin (5-HT) plays a crucial role in modulating the afferent fiber discharge rate in the inferior colliculus, auditory cortex, and other nuclei of the ascending auditory system. Resveratrol, a natural polyphenol phytoalexin, can inhibit serotonin transporters (SERT) to increase synaptic 5-HT levels. In this study, we investigated the effects of resveratrol on noise-induced damage in the serotonergic system. Male Sprague-Dawley rats were anaesthetized and exposed to an 8-kHz tone at 116 dB for 3.5 h. Resveratrol (30 mg/kg, intraperitoneal injection [IP]) and citalopram (20 mg/kg, IP), a specific SERT inhibitor used as a positive control, were administered once a day for four consecutive days, with the first treatment occurring 2 days before noise exposure. Auditory brainstem response testing and positron emission tomography (PET) with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM, a specific radioligand for SERT) were used to evaluate functionality of the auditory system and integrity of the serotonergic system, respectively, before and after noise exposure. Finally, immunohistochemistry was performed 1 day after the last PET scan. Our results indicate that noise-induced serotonergic fiber loss occurred in multiple brain regions including the midbrain, thalamus, hypothalamus, striatum, auditory cortex, and frontal cortex. This noise-induced damage to the serotonergic system was ameliorated in response to treatment with resveratrol and citalopram. However, noise exposure increased the hearing threshold in the rats regardless of drug treatment status. We conclude that resveratrol has protective effects against noise-induced loss of SERT.

High metabolic activity demonstrated by positron emission tomography in human auditory cortex in case of deafness of early onset

1993 ◽  
Vol 623 (2) ◽  
pp. 287-292 ◽  
Author(s):  
Mitzi Catalán-Ahumada ◽  
Naïma Deggouj ◽  
Anne De Volder ◽  
Jacques Melin ◽  
Christian Michel ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Auditory Cortex ◽  
Metabolic Activity ◽  
Early Onset ◽  
Emission Tomography ◽  
Positron Emission ◽  
Human Auditory Cortex ◽  
High Metabolic Activity

Tonotopic organization in human auditory cortex revealed by positron emission tomography

1985 ◽  
Vol 20 (3) ◽  
pp. 199-205 ◽  
Author(s):  
Judith L. Lauter ◽  
Peter Herscovitch ◽  
Craig Formby ◽  
Marcus E. Raichle
Keyword(s):  
Positron Emission Tomography ◽  
Auditory Cortex ◽  
Emission Tomography ◽  
Tonotopic Organization ◽  
Positron Emission ◽  
Human Auditory Cortex

Auditory cortex activity changes in long-term sensorineural deprivation during crude cochlear electrical stimulation: Evaluation by positron emission tomography

1995 ◽  
Vol 86 (1-2) ◽  
pp. 34-42 ◽  
Author(s):  
Eric Truy ◽  
Marie-Pierre Deiber ◽  
Luc Cinotti ◽  
François Mauguière ◽  
Jean-Claude Froment ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Electrical Stimulation ◽  
Auditory Cortex ◽  
Emission Tomography ◽  
Positron Emission

Positron Emission Tomography of Cocaine Binding Sites on the Dopamine Transporter

1994 ◽  
Author(s):  
Bertha K. Madras ◽  
◽  
David R. Elmaleh ◽  
Peter C. Meltzer ◽  
Anna Y. Liung ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Dopamine Transporter ◽  
Binding Sites ◽  
Emission Tomography ◽  
Positron Emission
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