Sensorineural Hearing Impairment, Non-Syndromic: DFNB5, 6, 7

2000 ◽  
pp. 152-157 ◽  
Author(s):  
K. Fukushima ◽  
Y. Ueki ◽  
R.J.H. Smith
Keyword(s):  
Hearing Impairment ◽  
Sensorineural Hearing ◽  
Sensorineural Hearing Impairment

scholarly journals MTHFR 677T Is a Strong Determinant of the Degree of Hearing Loss Among Polish Males with Postlingual Sensorineural Hearing Impairment

2012 ◽  
Vol 31 (7) ◽  
pp. 1267-1273 ◽  
Author(s):  
Agnieszka Pollak ◽  
Malgorzata Mueller-Malesinska ◽  
Urszula Lechowicz ◽  
Agata Skorka ◽  
Lech Korniszewski ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hearing Impairment ◽  
Sensorineural Hearing ◽  
Sensorineural Hearing Impairment

scholarly journals Consumption of betel quid contributes to sensorineural hearing impairment through arecoline-induced oxidative stress

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yen-Hui Chan ◽  
Tien-Chen Liu ◽  
Chun-Kang Liao ◽  
Yen-Fu Cheng ◽  
Ching-Hui Tsai ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hearing Impairment ◽  
Ex Vivo ◽  
Cell Activity ◽  
Reproductive Organs ◽  
Sensorineural Hearing ◽  
Betel Quid ◽  
Tissue Explants ◽  
Sensorineural Hearing Impairment ◽  
Z Scores

Abstract Betel quid is one of the most widely used psychoactive substances, and is consumed by approximately 10% of the world’s population. In addition to its carcinogenicity, betel quid has also been reported to affect many organs, including the brain, heart, lungs, gastrointestinal tract, and reproductive organs. As betel quid contains several neurotoxic ingredients, we hypothesize that it also possesses ototoxicity and may lead to sensorineural hearing impairment (SNHI). In this study, we investigated the contribution of betel quid consumption to SNHI in a large clinical cohort, and validated the pathogenetic mechanisms in ex vivo tissue explants. We enrolled a total of 2364 volunteers, and determined their audiologic results based on Z-scores converted from their original frequency-specific hearing thresholds. Using generalized linear regression, we identified a positive correlation between betel quid consumption and the Z-scores across different frequencies. Subsequently, we explored the toxicity of arecoline, the main neuroactive component of betel quid, on tissue explants from murine cochleae. Arecoline reduced cell activity in the explant cultures and induced apoptosis in the hair cells, probably through the effects of oxidative stress. These findings have expanded the potential hazards of betel quid to common neurological disorders, and provide insights into preventive strategies against SNHI caused by neurotoxic substances.

scholarly journals Bilateral sensorineural hearing impairment due to Streptococcus suis meningitis 20 days after swine bite

2013 ◽  
Vol 53 (9) ◽  
pp. 732-735 ◽  
Author(s):  
Kousuke Mori ◽  
Nobuyuki Ishii ◽  
Hitoshi Mochizuki ◽  
Akitoshi Taniguchi ◽  
Kazutaka Shiomi ◽  
...  
Keyword(s):  
Hearing Impairment ◽  
Streptococcus Suis ◽  
Sensorineural Hearing ◽  
Sensorineural Hearing Impairment
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