Mouse Models of Blood-Stage Malaria Infections: Immune Responses and Cytokines Involved in Protection and Pathology

2002 ◽  
pp. 204-228 ◽  
Author(s):  
J. Langhorne ◽  
S.J. Quin ◽  
L.A. Sanni
Keyword(s):  
Immune Responses ◽  
Mouse Models ◽  
Blood Stage ◽  
Blood Stage Malaria

scholarly journals Protection against malaria in mice is induced by blood stage–arresting histamine-releasing factor (HRF)–deficient parasites

2016 ◽  
Vol 213 (8) ◽  
pp. 1419-1428 ◽  
Author(s):  
Claudia Demarta-Gatsi ◽  
Leanna Smith ◽  
Sabine Thiberge ◽  
Roger Peronet ◽  
Pierre-Henri Commere ◽  
...  
Keyword(s):  
Immune Responses ◽  
Plasmodium Berghei ◽  
Blood Cells ◽  
Housekeeping Genes ◽  
Blood Stage ◽  
Parasite Development ◽  
Rodent Models ◽  
Cell Responses ◽  
Blood Stage Malaria

Although most vaccines against blood stage malaria in development today use subunit preparations, live attenuated parasites confer significantly broader and more lasting protection. In recent years, Plasmodium genetically attenuated parasites (GAPs) have been generated in rodent models that cause self-resolving blood stage infections and induce strong protection. All such GAPs generated so far bear mutations in housekeeping genes important for parasite development in red blood cells. In this study, using a Plasmodium berghei model compatible with tracking anti–blood stage immune responses over time, we report a novel blood stage GAP that lacks a secreted factor related to histamine-releasing factor (HRF). Lack of HRF causes an IL-6 increase, which boosts T and B cell responses to resolve infection and leave a cross-stage, cross-species, and lasting immunity. Mutant-induced protection involves a combination of antiparasite IgG2c antibodies and FcγR+ CD11b+ cell phagocytes, especially neutrophils, which are sufficient to confer protection. This immune-boosting GAP highlights an important role of opsonized parasite-mediated phagocytosis, which may be central to protection induced by all self-resolving blood stage GAP infections.

scholarly journals Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2

2020 ◽  
Vol 6 (9) ◽  
pp. eaay9269
Author(s):  
Yong Fu ◽  
Yan Ding ◽  
Qinghui Wang ◽  
Feng Zhu ◽  
Yulong Tan ◽  
...  
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Natural Killer ◽  
Underlying Mechanism ◽  
Innate Immune ◽  
Blood Stage ◽  
Innate Immune Responses ◽  
Malaria Parasites ◽  
Monocyte Chemoattractant Protein 1 ◽  
Blood Stage Malaria

Malaria parasites suppress host immune responses to facilitate their survival, but the underlying mechanism remains elusive. Here, we found that blood-stage malaria parasites predominantly induced CD4+Foxp3+CD25+ regulatory T cells to release soluble fibrinogen-like protein 2 (sFGL2), which substantially enhanced the infection. This was attributed to the capacity of sFGL2 to inhibit macrophages from releasing monocyte chemoattractant protein-1 (MCP-1) and to sequentially reduce the recruitment of natural killer/natural killer T cells to the spleen and the production of interferon-γ. sFGL2 inhibited c-Jun N-terminal kinase phosphorylation in the Toll-like receptor 2 signaling pathway of macrophages dependent on FcγRIIB receptor to release MCP-1. Notably, sFGL2 were markedly elevated in the sera of patients with malaria, and recombinant FGL2 substantially suppressed Plasmodium falciparum from inducing macrophages to release MCP-1. Therefore, we highlight a previously unrecognized immune suppression strategy of malaria parasites and uncover the fundamental mechanism of sFGL2 to suppress host innate immune responses.

scholarly journals Dichotomous miR expression and immune responses following primary blood-stage malaria

JCI Insight ◽  
2017 ◽  
Vol 2 (15) ◽  
Author(s):  
Julie G. Burel ◽  
Simon H. Apte ◽  
Penny L. Groves ◽  
Michelle J. Boyle ◽  
Christine Langer ◽  
...  
Keyword(s):  
Immune Responses ◽  
Blood Stage ◽  
Blood Stage Malaria

scholarly journals Lipocalin 2 Bolsters Innate and Adaptive Immune Responses to Blood-Stage Malaria Infection by Reinforcing Host Iron Metabolism

2012 ◽  
Vol 12 (5) ◽  
pp. 705-716 ◽  
Author(s):  
Hong Zhao ◽  
Aki Konishi ◽  
Yukiko Fujita ◽  
Masanori Yagi ◽  
Keiichi Ohata ◽  
...  
Keyword(s):  
Immune Responses ◽  
Iron Metabolism ◽  
Malaria Infection ◽  
Blood Stage ◽  
Lipocalin 2 ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Blood Stage Malaria

Immune Responses to Whole-Organism Blood-Stage Malaria Vaccines

Malaria ◽  
2017 ◽  
pp. 197-210
Author(s):  
Amber I. Raja ◽  
Danielle I. Stanisic ◽  
Michael F. Good
Keyword(s):  
Immune Responses ◽  
Blood Stage ◽  
Malaria Vaccines ◽  
Blood Stage Malaria
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