The Role of CD26/DPP IV in Chemokine Processing

Role of zonulin and GLP-1/DPP-IV in alleviation of diabetes mellitus by peptide/polypeptide fraction of Aloe vera in streptozotocin- induced diabetic wistar rats

Journal of Ethnopharmacology ◽

10.1016/j.jep.2021.113949 ◽

2021 ◽

Vol 272 ◽

pp. 113949

Author(s):

Spoorthy N. Babu ◽

S. Govindarajan ◽

M.A. Vijayalakshmi ◽

Ayesha Noor

Keyword(s):

Diabetes Mellitus ◽

Wistar Rats ◽

Aloe Vera ◽

Dpp Iv

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2437Insulin triggers oxidative stress in the vascular wall of patients with atherosclerosis, independently of systemic insulin resistance: the beneficial role of DPP-IV inhibition

European Heart Journal ◽

10.1093/eurheartj/ehy565.2437 ◽

2018 ◽

Vol 39 (suppl_1) ◽

Cited By ~ 1

Author(s):

I Akoumianakis ◽

L Herdman ◽

M Margaritis ◽

R Sayeed ◽

G Krasopoulos ◽

...

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Vascular Wall ◽

Beneficial Role ◽

Dpp Iv ◽

Systemic Insulin Resistance

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Critical Role of Dipeptidyl Peptidase IV: A Therapeutic Target for Diabetes and Cancer

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557518666180423112154 ◽

2018 ◽

Vol 19 (2) ◽

pp. 88-97 ◽

Cited By ~ 7

Author(s):

Sourav De ◽

Subhasis Banerjee ◽

S.K. Ashok Kumar ◽

Priyankar Paira

Keyword(s):

Drug Targets ◽

Critical Role ◽

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Dpp Iv ◽

Protease Enzyme ◽

Target Disease ◽

Dimeric Form ◽

Epithelium Cells

Diabetes mellitus is an emerging predator and affecting around 422 million adults worldwide. Higher levels of circulating insulin and increased pressure on the pancreas to produce insulin have been inferred as possible etiology for diabetes leading to a higher risk of pancreatic cancer. Out of several drug targets in hypoglycemic discovery, Dipeptidyl peptidase-IV (DPP-IV) has been considered an emerging target. It is a protease enzyme which inactivates incretin hormones i.e., Glucagonlike peptide 1 (GLP-1) and glucose-dependent insulin tropic polypeptide (GIP). Inhibition of DPP-4 results in the longer action of GLP-1 and GIP, therefore, DPP-4 inhibitors play an important role in maintaining glucose homeostasis. In comparison to early oral hypoglycemic, DPP-IV inhibitors are well tolerated and provide a better glycemic control over a longer period. These enzymes are expressed in a dimeric form on the surface of different cells such as prostate, liver and small intestinal epithelium cells. Disruption of the local signaling environment is an emerging factor in cancer development. Till date, not even a single DPP-IV inhibitor as anticancer has been developed. This review focuses on various features of the enzyme and their suitable inhibitors for target disease.

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Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9

FEBS Letters ◽

10.1016/j.febslet.2011.10.009 ◽

2011 ◽

Vol 585 (21) ◽

pp. 3409-3414 ◽

Cited By ~ 10

Author(s):

Hung-Kuan Tang ◽

Ku-Chuan Chen ◽

Gan-Guang Liou ◽

Shu-Chun Cheng ◽

Chia-Hui Chien ◽

...

Keyword(s):

Enzymatic Activity ◽

Quaternary Structure ◽

Dpp Iv

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Inhibition of CD26/DPP IV attenuates ischemia/reperfusion injury in orthotopic mouse lung transplants: The pivotal role of vasoactive intestinal peptide

Peptides ◽

10.1016/j.peptides.2009.12.012 ◽

2010 ◽

Vol 31 (4) ◽

pp. 585-591 ◽

Cited By ~ 30

Author(s):

Wolfgang Jungraithmayr ◽

Ingrid De Meester ◽

Veerle Matheeussen ◽

Ilhan Inci ◽

Koen Augustyns ◽

...

Keyword(s):

Reperfusion Injury ◽

Vasoactive Intestinal Peptide ◽

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Pivotal Role ◽

Mouse Lung ◽

Dpp Iv ◽

Lung Transplants

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Emerging Role of Caveolin-1 in GLP-1 Action

Frontiers in Endocrinology ◽

10.3389/fendo.2021.668012 ◽

2021 ◽

Vol 12 ◽

Author(s):

Alessandra Puddu ◽

Davide Maggi

Keyword(s):

Intracellular Signaling ◽

Biological Effects ◽

Receptor Internalization ◽

Intestinal Epithelial ◽

Caveolin 1 ◽

Dpp Iv ◽

Gut Hormone ◽

Glucagon Like Peptide 1 ◽

Main Component

Glucagon-like peptide-1 (GLP-1) is a gut hormone mainly produced in the intestinal epithelial endocrine L cells, involved in maintaining glucose homeostasis. The use of GLP-1 analogous and dipeptidyl peptidase-IV (DPP-IV) inhibitors is well-established in Type 2 Diabetes. The efficacy of these therapies is related to the activation of GLP-1 receptor (GLP-1R), which is widely expressed in several tissues. Therefore, GLP-1 is of great clinical interest not only for its actions at the level of the beta cells, but also for the extra-pancreatic effects. Activation of GLP-1R results in intracellular signaling that is regulated by availability of downstream molecules and receptor internalization. It has been shown that GLP-1R co-localizes with caveolin-1, the main component of caveolae, small invagination of the plasma membrane, which are involved in controlling receptor activity by assembling signaling complexes and regulating receptor trafficking. The aim of this review is to outline the important role of caveolin-1 in mediating biological effects of GLP-1 and its analogous.

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Colonic inflammation induces changes in glucose levels through modulation of incretin system

Pharmacological Reports ◽

10.1007/s43440-021-00327-y ◽

2021 ◽

Author(s):

Hubert Zatorski ◽

Maciej Salaga ◽

Marta Zielińska ◽

Anna Mokrowiecka ◽

Damian Jacenik ◽

...

Keyword(s):

Glucose Level ◽

Healthy Subjects ◽

Fasting Glucose ◽

Control Group ◽

Trinitrobenzenesulfonic Acid ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Dpp Iv ◽

Prohormone Convertase 1

Abstract Background The role of the incretin hormone, glucagon-like peptide (GLP-1), in Crohn’s disease (CD), is still poorly understood. The aim of this study was to investigate whether colitis is associated with changes in blood glucose levels and the possible involvement of the incretin system as an underlaying factor. Methods We used a murine model of colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Macroscopic and microscopic score and expression of inflammatory cytokines were measured. The effect of colitis on glucose level was studied by measurement of fasting glucose and GLP-1, dipeptidyl peptidase IV (DPP IV) levels, prohormone convertase 1/3 (PC 1/3) and GLP-1 receptor (GLP-1R) expression in mice. We also measured the level of GLP-1, DPP IV and expression of glucagon (GCG) and PC 1/3 mRNA in serum and colon samples from healthy controls and CD patients. Results Fasting glucose levels were increased in animals with colitis compared to controls. GLP-1 was decreased in both serum and colon of mice with colitis in comparison to the control group. DPP IV levels were significantly increased in serum, but not in the colon of mice with colitis as compared to healthy animals. Furthermore, PC 1/3 and GLP-1R expression levels were increased in mice with colitis as compared to controls. In humans, no differences were observed in fasting glucose level between healthy subjects and CD patients. GLP-1 levels were significantly decreased in the serum. Interestingly, GLP-1 level was significantly increased in colon samples of CD patients compared to healthy subjects. No significant differences in DPP IV levels in serum and colon samples were observed between groups. Conclusions Changes in the incretin system during colitis seem to contribute to the impaired glucose levels. Differences in incretin levels seem to be modulated by degrading enzyme DPP-IV and PC 1/3. Obtained results suggest that the incretin system may become a novel therapeutic approach in the treatment of CD.

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The Role of CD26/DPP IV in Preservation of Early Pulmonary Graft Function

Advances in Experimental Medicine and Biology - Dipeptidyl Aminopeptidases ◽

10.1007/0-387-32824-6_25 ◽

2006 ◽

pp. 231-235

Author(s):

Florian Johannes Jung ◽

Markus Cardell ◽

Lin Yang ◽

Ingrid De Meester ◽

Koen Augustyns ◽

...

Keyword(s):

Graft Function ◽

Dpp Iv

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Genetic evidence for role of DPP IV in intestinal hydrolysis and assimilation of prolyl peptides

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1993.265.1.g81 ◽

1993 ◽

Vol 265 (1) ◽

pp. G81-G89 ◽

Cited By ~ 5

Author(s):

C. Tiruppathi ◽

Y. Miyamoto ◽

V. Ganapathy ◽

F. H. Leibach

Keyword(s):

Brush Border ◽

Normal Activity ◽

Intestinal Lumen ◽

Brush Border Membranes ◽

In Situ Perfusion ◽

Dpp Iv ◽

Hydrolytic Activities ◽

The Difference ◽

F344 Rats

The functional role of dipeptidyl peptidase IV (DPP IV) in the intestinal hydrolysis and assimilation of prolyl peptides was investigated using Japan F344 rats, which genetically lack this enzyme. USA F344 rats possess normal activity of this enzyme and served as matched controls. Intestinal brush-border membranes from the control rats were able to hydrolyze several proline-containing peptides. The hydrolytic ability of the brush-border membranes from the Japan rats against these peptides was markedly low. The difference in the hydrolytic activities between the two groups of rats was solely due to the absence of DPP IV in the Japan rats. There was no difference in the growth rate between the two groups of rats fed a reference diet whose protein constituents were not rich in proline. When the protein source was changed to gliadin, a proline-rich protein, USA F344 rats maintained their body weight for a 4-wk period on this diet, whereas the Japan rats experienced a significant weight loss under similar conditions. In situ perfusion experiments in intact animals revealed that the ability of morphiceptin (a peptide primarily hydrolyzable by DPP IV), when administered into the intestinal lumen, to block the cholera toxin-induced water secretion was significantly greater in Japan F344 rats than in USA F344 rats, indicating the resistance of morphiceptin to hydrolytic breakdown in the intestinal lumen of the Japan rats. It is concluded that the intestinal DPP IV plays a significant role in the hydrolysis of prolyl peptides and assimilation of proline-rich proteins.

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