Enteric Helminth Infection: Immunopathology and Resistance during Intestinal Nematode Infection

1997 ◽  
pp. 41-61 ◽  
Author(s):  
R.K. Grencis
Keyword(s):  
Helminth Infection ◽  
Nematode Infection ◽  
Intestinal Nematode

scholarly journals Intestinal Nematode Infection Ameliorates Experimental Colitis in Mice

2002 ◽  
Vol 70 (11) ◽  
pp. 5931-5937 ◽  
Author(s):  
W. I. Khan ◽  
P. A. Blennerhasset ◽  
A. K. Varghese ◽  
S. K. Chowdhury ◽  
P. Omsted ◽  
...  
Keyword(s):  
Immune Response ◽  
Trichinella Spiralis ◽  
Experimental Colitis ◽  
Developed Countries ◽  
Epidemiological Studies ◽  
Nematode Infection ◽  
Th2 Cells ◽  
Th2 Response ◽  
Th1 Cell ◽  
Intestinal Nematode

ABSTRACT Epidemiological studies suggest that inflammatory bowel disease (IBD) is common in developed countries and rare in countries where intestinal nematode infections are common. T cells are critical in many immune responses, including those associated with IBD and nematode infection. Among the distinct T helper (Th) cell subsets, Th1-type immune response is predominantly associated with Crohn's disease, while many nematode infections generate a strong Th2 response. The reciprocal cross regulation between Th1 and Th2 cells suggests that generation of a Th2 response by nematodes could prevent or reduce the effects of Th1-mediated diseases. In the present study, we investigated the effect of polarizing the immune response toward the Th2 type, using intestinal nematode infection, on subsequent experimental colitis. Mice were infected with the intestinal nematode Trichinella spiralis and allowed to recover before colitis was induced with dinitrobenzene sulfonic acid. The mice were sacrificed postcolitis to assess colonic damage macroscopically, histologically, and by myeloperoxidase (MPO) activity and Th cytokines. Prior nematode infection reduced the severity of colitis both macroscopically and histologically together with a decreased mortality and was correlated with a down-regulation of MPO activity, Th1-type cytokine expression in colonic tissue, and emergence of a Th2-type immune response. These results indicate a protective role of nematode infection in Th1 cell-driven inflammation and prompt consideration of a novel therapeutic strategy in IBD based on immunological distraction.

Seasonal trends in intestinal nematode infection and medicinal plant use among chimpanzees in the Mahale Mountains, Tanzania

Primates ◽  
1997 ◽  
Vol 38 (2) ◽  
pp. 111-125 ◽  
Author(s):  
Michael A. Huffman ◽  
Shunji Gotoh ◽  
Linda A. Turner ◽  
Miya Hamai ◽  
Kozo Yoshida
Keyword(s):  
Medicinal Plant ◽  
Nematode Infection ◽  
Seasonal Trends ◽  
Mahale Mountains ◽  
Plant Use ◽  
Intestinal Nematode

T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection

2009 ◽  
Vol 39 (8) ◽  
pp. 2173-2183 ◽  
Author(s):  
Nicolas Fasnacht ◽  
Marina C. Greweling ◽  
Mariela Bollati-Fogolín ◽  
Angela Schippers ◽  
Werner Müller
Keyword(s):  
T Cell ◽  
Nematode Infection ◽  
Deficient Mouse ◽  
Intestinal Nematode ◽  
Specific Deletion

scholarly journals Maternal Nematode Infection Upregulates Expression of Th2/Treg and Diapedesis Related Genes In The Neonatal Brain

2021 ◽  
Author(s):  
Nawal El Ahdab ◽  
Manjurul Haque ◽  
Kristine G. Koski ◽  
Marilyn E. Scott
Keyword(s):  
Gene Expression ◽  
Secondary Analysis ◽  
Nematode Infection ◽  
Maternal Infection ◽  
Neonatal Brain ◽  
Brain Gene Expression ◽  
Intestinal Nematode ◽  
Expression Of Genes ◽  
Endothelial Migration ◽  
Related Proteins

Abstract Intestinal nematode infections common during pregnancy have recently been shown to have impacts that extend to their uninfected offspring including altered brain gene expression. If maternal immune signals reach the neonatal brain, they might alter neuroimmune development. We explored expression of genes associated with four distinct types of T cells (Th1, Th2, Th17, Treg) and with leukocyte trans-endothelial migration and endocytosis transport across the blood-brain barrier (BBB) in the postnatal brain of offspring of nematode-infected mice, through secondary analysis of a whole brain gene expression database. Th1/Th17 expression was lowered by maternal infection as evidenced by down-regulated expression of IL-1β, Th1 receptors and related proteins, and of IL22 and several Th17 genes associated immunopathology. In contrast, Th2/Treg related pathways were upregulated as shown by higher expression of IL-4 and TGF-β family genes. Maternal infection also upregulated expression of pathways and integrin genes involved in transport of leukocytes in between endothelial cells but downregulated endosome vesicle formation related genes that are necessary for endocytosis of immunoglobulins across the BBB. Taken together, pup brain gene expression indicates that maternal nematode infection enhanced movement of leukocytes across the neonatal BBB and promoted a Th2/Treg environment that presumably minimizes the proinflammatory Th1 response in the pup brain.

Intestinal nematode infection exacerbates experimental visceral leishmaniasis

2019 ◽  
Vol 41 (4) ◽  
pp. e12618 ◽  
Author(s):  
Cajsa Classon ◽  
Xiaogang Feng ◽  
Liv Eidsmo ◽  
Susanne Nylén
Keyword(s):  
Visceral Leishmaniasis ◽  
Nematode Infection ◽  
Intestinal Nematode

Stat6 dependent goblet cell hyperplasia during intestinal nematode infection

2001 ◽  
Vol 23 (1) ◽  
pp. 39-42 ◽  
Author(s):  
W.I. Khan ◽  
P. Blennerhasset ◽  
C. Ma ◽  
K.I. Matthaei ◽  
S.M. Collins
Keyword(s):  
Goblet Cell ◽  
Nematode Infection ◽  
Cell Hyperplasia ◽  
Goblet Cell Hyperplasia ◽  
Intestinal Nematode

Levels of helminth infection in the flat lizard Tropidurus semitaeniatus from north-eastern Brazil

2015 ◽  
Vol 90 (6) ◽  
pp. 779-783 ◽  
Author(s):  
C.H. Bezerra ◽  
R.W. Ávila ◽  
D.C. Passos ◽  
D. Zanchi-Silva ◽  
C.A.B. Galdino
Keyword(s):  
Body Size ◽  
Helminth Infection ◽  
Helminth Species ◽  
Intestinal Helminth ◽  
Helminth Parasites ◽  
Intestinal Nematode ◽  
Eastern Brazil ◽  
Host Sex ◽  
North Eastern ◽  
First Time

AbstractParasites represent a great, unknown component of animal biodiversity. Recent efforts have begun to uncover patterns of infection by helminth parasites in several Neotropical lizards. The present study reports, for the first time, levels of helminth infection in a population of the flat lizard Tropidurus semitaeniatus. One hundred and thirty-nine lizards were examined and evidence of five intestinal helminth species was found, comprising four species of nematodes, one species of cestode and an unidentified encysted larval nematode. The most frequently occurring species was the intestinal nematode Parapharyngodon alvarengai, which did not exhibit differences in prevalence and intensity of infection relative to host sex or age/body size. Furthermore, helminth species richness was not related to host body size.

WITHDRAWN: Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection

2005 ◽  
Author(s):  
Joseph D. Turner ◽  
Helen Faulkner ◽  
Joseph Kamgno ◽  
Malcolm W. Kennedy ◽  
Jerzy Behnke ◽  
...  
Keyword(s):  
Specific Ige ◽  
Nematode Infection ◽  
Intestinal Nematode
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