Modification of Peanut Allergen Ara h 3: Effects on IgE Binding and T Cell Stimulation

2002 ◽  
Vol 128 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Pat Rabjohn ◽  
C. Michael West ◽  
Cathie Connaughton ◽  
Hugh A. Sampson ◽  
Ricki M. Helm ◽  
...  
Keyword(s):  
T Cell ◽  
Peanut Allergen ◽  
Cell Stimulation ◽  
Ige Binding ◽  
T Cell Stimulation ◽  
Ara H 3

Engineered Alt a 13 Fragment of Alternaria alternata Abrogated IgE Binding without Affecting T-cell Stimulation

2008 ◽  
Vol 29 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Jay Shankar ◽  
Bhanu P. Singh ◽  
Shailendra N. Gaur ◽  
Naveen Arora
Keyword(s):  
T Cell ◽  
Alternaria Alternata ◽  
Cell Stimulation ◽  
Ige Binding ◽  
T Cell Stimulation

Human dendritic cell-derived osteoclasts have the ability for both bone absorption and T cell stimulation

2016 ◽  
Author(s):  
Manabu Narisawa ◽  
Satoshi Kubo ◽  
Shingo Nakayamada ◽  
Jidong Zhao ◽  
Kei Sakata ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Human Dendritic Cell ◽  
Cell Stimulation ◽  
Bone Absorption ◽  
T Cell Stimulation

scholarly journals Robust T-cell stimulation by Epstein-Barr virus–transformed B cells after antigen targeting to DEC-205

Blood ◽  
2013 ◽  
Vol 121 (9) ◽  
pp. 1584-1594 ◽  
Author(s):  
Carol S. Leung ◽  
Michael A. Maurer ◽  
Sonja Meixlsperger ◽  
Anne Lippmann ◽  
Cheolho Cheong ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Epstein Barr Virus ◽  
Cell Stimulation ◽  
Barr Virus ◽  
T Cell Stimulation ◽  
Key Points ◽  
Epstein Barr ◽  
Mhc Presentation ◽  
Activated B Cells

Key Points B cells contribute to MHC presentation of DEC-205–targeted antigen. Activated B cells present DEC-205–targeted antigen efficiently, because they retain it longer.

scholarly journals COP9 signalosome controls the Carma1–Bcl10–Malt1 complex upon T‐cell stimulation

EMBO Reports ◽  
2009 ◽  
Vol 10 (6) ◽  
pp. 642-648 ◽  
Author(s):  
Verena Welteke ◽  
Andrea Eitelhuber ◽  
Michael Düwel ◽  
Katrin Schweitzer ◽  
Michael Naumann ◽  
...  
Keyword(s):  
T Cell ◽  
Cop9 Signalosome ◽  
Cell Stimulation ◽  
T Cell Stimulation

scholarly journals Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells

Blood ◽  
2010 ◽  
Vol 116 (26) ◽  
pp. 5875-5884 ◽  
Author(s):  
Hideaki Tanizaki ◽  
Gyohei Egawa ◽  
Kayo Inaba ◽  
Tetsuya Honda ◽  
Saeko Nakajima ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
T Cell ◽  
Immune Responses ◽  
Lymph Nodes ◽  
Actin Polymerization ◽  
Cell Stimulation ◽  
T Cell Stimulation ◽  
Acquired Immune Responses

Abstract Dendritic cells (DCs) are essential for the initiation of acquired immune responses through antigen acquisition, migration, maturation, and T-cell stimulation. One of the critical mechanisms in this response is the process actin nucleation and polymerization, which is mediated by several groups of proteins, including mammalian Diaphanous-related formins (mDia). However, the role of mDia in DCs remains unknown. Herein, we examined the role of mDia1 (one of the isoforms of mDia) in DCs. Although the proliferation and maturation of bone marrow-derived DCs were comparable between control C57BL/6 and mDia1-deficient (mDia1−/−) mice, adhesion and spreading to cellular matrix were impaired in mDia1−/− bone marrow–derived DCs. In addition, fluorescein isothiocyanate-induced cutaneous DC migration to draining lymph nodes in vivo and invasive migration and directional migration to CCL21 in vitro were suppressed in mDia1−/− DCs. Moreover, sustained T-cell interaction and T-cell stimulation in lymph nodes were impaired by mDia1 deficiency. Consistent with this, the DC-dependent delayed hypersensitivity response was attenuated by mDia1-deficient DCs. These results suggest that actin polymerization, which is mediated by mDia1, is essential for several aspects of DC-initiated acquired immune responses.

Sign in / Sign up

Export Citation Format

Share Document