Insulin-Like Growth Factors and Insulin-Like Growth Factor Binding Proteins in Adult Patients with Severe Liver Disease before and after Orthotopic Liver Transplantation

2002 ◽  
Vol 57 (3-4) ◽  
pp. 105-112 ◽  
Author(s):  
Matthias M. Weber ◽  
Christoph J. Auernhammer ◽  
Phillip D.K. Lee ◽  
Dieter Engelhardt ◽  
Reinhart Zachoval
Keyword(s):  
Liver Transplantation ◽  
Growth Factors ◽  
Liver Disease ◽  
Growth Factor ◽  
Orthotopic Liver Transplantation ◽  
Binding Proteins ◽  
Severe Liver ◽  
Before And After ◽  
Severe Liver Disease ◽  
Insulin Like Growth Factors

scholarly journals Concentrations of Insulin-like Growth Factors and Insulin-like Growth Factor-Binding Proteins and Respective Gene Expressions in Children before and after Hematopoietic Stem Cell Transplantation

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4333
Author(s):  
Wojciech Strojny ◽  
Wojciech Czogała ◽  
Przemysław Tomasik ◽  
Mirosław Bik-Multanowski ◽  
Małgorzata Wójcik ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factors ◽  
Growth Factor ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Healthy Controls ◽  
Hematopoietic Stem ◽  
Before And After ◽  
Insulin Like Growth Factors

Insulin-like growth factors (IGF-1 and IGF-2) and insulin-like growth factor-binding proteins (IGFBP-1 to -7) are involved in the regulation of cell proliferation and differentiation and may be associated with various metabolic parameters. The aim of our study was to compare levels of IGFs and IGFBPs and the expressions of their genes in children before and after hematopoietic stem cell transplantation (HSCT) to assess their potential as markers of late metabolic complications of HSCT. We also conducted additional comparisons with healthy controls and of correlations of IGF and IGFBP levels with anthropometric and biochemical parameters. We analyzed 19 children treated with HSCT and 21 healthy controls. We found no significant differences in the levels of IGFs and IGFBPs and expressions of their genes before and after HSCT, while IGF and IGFBP levels were significantly lower in children treated with HSCT compared with controls. We conclude that our results did not reveal significant differences between the levels of IGFs and IGFBPs before and after HSCT, which would make them obvious candidates for markers of late complications of the procedure in children. However, due to the very low number of patients this conclusion must be taken with caution and may be altered by further research.

Serum insulin-like growth factors and their binding proteins in patients with hepatic failure and after liver transplantation

Metabolism ◽  
1998 ◽  
Vol 47 (2) ◽  
pp. 200-206 ◽  
Author(s):  
Don S. Schalch ◽  
Munci Kalayoglu ◽  
John D. Pirsch ◽  
Huan Yang ◽  
Marc Raslich ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Growth Factors ◽  
Hepatic Failure ◽  
Binding Proteins ◽  
Serum Insulin ◽  
Insulin Like Growth Factors
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