Peak Systolic Velocity Doppler Index Reflects Most Appropriately the Dynamic Time Course of Intact Cerebral Autoregulation

2002 ◽  
Vol 13 (4) ◽  
pp. 230-234 ◽  
Author(s):  
B. Rosengarten ◽  
M. Kaps
Keyword(s):  
Cerebral Autoregulation ◽  
Time Course ◽  
Peak Systolic Velocity ◽  
Dynamic Time

Superoxide dismutase in the nonobese diabetic (NOD) mouse: A dynamic time-course study

Life Sciences ◽  
1995 ◽  
Vol 56 (25) ◽  
pp. 2223-2228 ◽  
Author(s):  
Gianpaolo Papaccio ◽  
Sonia Frascatore ◽  
Francesco Aurelio Pisanti ◽  
Michael V.G. Latronico ◽  
Thomas Linn
Keyword(s):  
Superoxide Dismutase ◽  
Time Course ◽  
Nod Mouse ◽  
Nonobese Diabetic ◽  
Time Course Study ◽  
Dynamic Time

Disease progression and regression in sporadic small vessel disease–insights from neuroimaging

2017 ◽  
Vol 131 (12) ◽  
pp. 1191-1206 ◽  
Author(s):  
Esther M.C. van Leijsen ◽  
Frank-Erik de Leeuw ◽  
Anil M. Tuladhar
Keyword(s):  
Disease Progression ◽  
Time Course ◽  
Temporal Dynamics ◽  
Small Vessel Disease ◽  
Small Vessel ◽  
Course Of Disease ◽  
Vessel Disease ◽  
Clinical Consequences ◽  
Dynamic Time

Cerebral small vessel disease (SVD) is considered the most important vascular contributor to the development of dementia. Comprehensive characterization of the time course of disease progression will result in better understanding of aetiology and clinical consequences of SVD. SVD progression has been studied extensively over the years, usually describing change in SVD markers over time using neuroimaging at two time points. As a consequence, SVD is usually seen as a rather linear, continuously progressive process. This assumption of continuous progression of SVD markers was recently challenged by several studies that showed regression of SVD markers. Here, we provide a review on disease progression in sporadic SVD, thereby taking into account both progression and regression of SVD markers with emphasis on white matter hyperintensities (WMH), lacunes and microbleeds. We will elaborate on temporal dynamics of SVD progression and discuss the view of SVD progression as a dynamic process, rather than the traditional view of SVD as a continuous progressive process, that might better fit evidence from longitudinal neuroimaging studies. We will discuss possible mechanisms and clinical implications of a dynamic time course of SVD, with both progression and regression of SVD markers.

Transcranial Doppler ultrasound studies of cerebral autoregulation and subarachnoid hemorrhage in the rabbit

1990 ◽  
Vol 73 (4) ◽  
pp. 601-610 ◽  
Author(s):  
Richard J. Nelson ◽  
Sheila Perry ◽  
Tony K. Hames ◽  
John D. Pickard
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Flow Velocity ◽  
Doppler Ultrasound ◽  
Transcranial Doppler ◽  
Cerebral Autoregulation ◽  
Time Course ◽  
Cerebrovascular Reactivity ◽  
Waveform Analysis ◽  
Content Type ◽  
Fine Print

✓ The authors describe a method for Doppler ultrasound recording of flow velocity in the basilar artery of normal rabbits and rabbits with experimental subarachnoid hemorrhage (SAH). With this transcranial Doppler (TCD) model, clinical assumptions regarding flow velocity/cerebral blood flow (CBF) relationships, autoregulatory responses, and Doppler spectral waveform analysis can be tested under controlled conditions and compared with established methods of CBF measurement (hydrogen clearance). The time course of changes in flow velocity following SAH (cerebral vasospasm) is successfully demonstrated using the experimental TCD method. There are significant differences in the flow velocity and CBF responses to hypercapnia, hypocapnia, and trimethaphan-induced hypotension which indicate that TCD cannot be considered a simple alternative to CBF measurement for the study of cerebrovascular reactivity and cerebral autoregulation.

The dynamic time course of stereotype activation: Activation, dissipation, and resurrection.

2002 ◽  
Vol 82 (3) ◽  
pp. 283-299 ◽  
Author(s):  
Ziva Kunda ◽  
Paul G. Davies ◽  
Barbara D. Adams ◽  
Steven J. Spencer
Keyword(s):  
Time Course ◽  
Stereotype Activation ◽  
Dynamic Time

Abstract 6189: Stent Fracture does not Affect Long Term Patency in the Femoro-popliteal Artery: Four Years Experience

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Osamu Iida ◽  
Shinsuke Nanto ◽  
Masaaki Uematsu ◽  
Takakazu Morozumi ◽  
Tetsuya Watanabe ◽  
...  
Keyword(s):  
Time Course ◽  
Velocity Ratio ◽  
Peak Systolic Velocity ◽  
Primary Patency ◽  
Stent Fracture ◽  
X Ray ◽  
Nitinol Stents ◽  
Provisional Stenting

[Background] Stent fracture in the femoro-popiteal (FP) artery has been related to poor long term patency. However, time course of patency with and without stent fracture beyond 2 years has not been explored. [Methods] We studied consecutive 334 FP lesions that received provisional stenting with metallic or nitinol stents (Luminexx, Bard: 90 lesions and Smart, Cordis: 243 lesions). Stent fracture was determined by X-ray with multiple projections. Patency was either assessed by Duplex ultrasonography as peak systolic velocity ratio > 2.5 or by angiography (% diameter stenosis > 50%). [Results] Stent fracture occurred in 19% (55/334) lesions and restenosis rate at mean follow up (16+/−12 months) was 20% (67/334). Primary patency with or without stent fracture was 83% with fracture versus 68% without fracture at 1 year, p=0.03; 75% versus 60% at 2 years, p=0.04; 68% versus. 60% at 3 years, p=0.05; 63% versus 60% at 4 years, p=0.06. [Conclusion] Stent fracture affected the patency during the first 2 years, but unlikely affected the patency beyond 4 years.

Dynamic Time-Course Studies of the Spontaneously Diabetic BB Wistar Rat. II. Insulin-, Glucagon-, and Somatostatin-Reactive Cells in the Pancreas*

Endocrinology ◽  
1981 ◽  
Vol 109 (6) ◽  
pp. 1880-1887 ◽  
Author(s):  
GLORIA SHAFFER TANNENBAUM ◽  
ELEANOR COLLE ◽  
LAURA WANAMAKER ◽  
WENDY GURD ◽  
HY GOLDMAN ◽  
...  
Keyword(s):  
Time Course ◽  
Wistar Rat ◽  
Dynamic Time

scholarly journals Enhancing carbohydrate repartitioning into lipid and carotenoid by disruption of microalgae starch debranching enzyme

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Yuichi Kato ◽  
Tomoki Oyama ◽  
Kentaro Inokuma ◽  
Christopher J. Vavricka ◽  
Mami Matsuda ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Time Course ◽  
Biofuel Production ◽  
Microalgae Cultivation ◽  
Dark Cycle ◽  
Gene Encoding ◽  
Debranching Enzyme ◽  
Carbohydrate Degradation ◽  
Starch Debranching Enzyme ◽  
Dynamic Time

AbstractLight/dark cycling is an inherent condition of outdoor microalgae cultivation, but is often unfavorable for lipid accumulation. This study aims to identify promising targets for metabolic engineering of improved lipid accumulation under outdoor conditions. Consequently, the lipid-rich mutant Chlamydomonas sp. KOR1 was developed through light/dark-conditioned screening. During dark periods with depressed CO2 fixation, KOR1 shows rapid carbohydrate degradation together with increased lipid and carotenoid contents. KOR1 was subsequently characterized with extensive mutation of the ISA1 gene encoding a starch debranching enzyme (DBE). Dynamic time-course profiling and metabolomics reveal dramatic changes in KOR1 metabolism throughout light/dark cycles. During light periods, increased flux from CO2 through glycolytic intermediates is directly observed to accompany enhanced formation of small starch-like particles, which are then efficiently repartitioned in the next dark cycle. This study demonstrates that disruption of DBE can improve biofuel production under light/dark conditions, through accelerated carbohydrate repartitioning into lipid and carotenoid.

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