Blunted Nocturnal Blood Pressure Decrease and Left-Ventricular Mass in Hypertensive Hemodialysis Patients

Nephron ◽  
2002 ◽  
Vol 91 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Riccardo M. Fagugli ◽  
Giuseppe Quintaliani ◽  
Paolo Pasini ◽  
Giovanni Ciao ◽  
Beatrice Cicconi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Mass ◽  
Hemodialysis Patients ◽  
Left Ventricular ◽  
Blood Pressure Decrease ◽  
Nocturnal Blood Pressure ◽  
Ventricular Mass ◽  
Pressure Decrease

Blood Pressure Measurements and Left Ventricular Mass Index in Hemodialysis Patients

2012 ◽  
Vol 36 (6) ◽  
pp. 517-524 ◽  
Author(s):  
Robert Ekart ◽  
Vojko Kanič ◽  
Breda Pečovnik-Balon ◽  
Sebastjan Bevc ◽  
Benjamin Dvoršak ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Hemodialysis Patients ◽  
Left Ventricular ◽  
Pressure Measurements ◽  
Ventricular Mass Index ◽  
Ventricular Mass

scholarly journals Nocturnal antihypertensive treatment in patients with type 1 diabetes with autonomic neuropathy and non-dipping of blood pressure during night time: protocol for a randomised, placebo-controlled, double-blind, two-way crossover study

BMJ Open ◽  
2014 ◽  
Vol 4 (10) ◽  
pp. e006142 ◽  
Author(s):  
Henrik Hjortkær ◽  
Tonny Jensen ◽  
Klaus Kofoed ◽  
Ulrik Mogensen ◽  
Lars Køber ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Treatment Period ◽  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Night Time ◽  
Double Blind ◽  
Nocturnal Blood Pressure ◽  
Ventricular Mass

IntroductionCardiac autonomic neuropathy (CAN) and elevated nocturnal blood pressure are independent risk factors for cardiovascular disease in patients with diabetes. Previously, associations between CAN, non-dipping of nocturnal blood pressure and coronary artery calcification have been demonstrated. The present protocol describes a trial to test the efficacy of bedtime dosing of the ACE inhibitor enalapril on night time blood pressure and left ventricular mass in patients with type 1 diabetes.Materials and methodsIn a randomised, double-blind, two-way cross-over study, 24 normoalbuminuric patients with type 1 diabetes with CAN will be treated for 12 weeks with either morning or bedtime dosing of 20 mg enalapril, followed by 12 weeks of switched treatment regimen. During each treatment period, two 24 h ambulatory blood pressure measurements will be performed and after each treatment period left ventricular mass will be determined by multisliced CT. Primary end points will be reduction in blood pressure and reduction in left ventricular mass.Ethics and disseminationThe study has been approved by the Danish Medicines Agency, the Scientific-Ethical Committee of the Capital Region of Denmark and the Danish Data Protection Agency. An external monitoring committee (the Good Clinical Practice Unit at Copenhagen University Hospital) will oversee the study. The results of the study will be presented at national and international scientific meetings and publications will be submitted to peer-reviewed journals.Trial registration numberEudraCT (2012- 002136-90).

scholarly journals Predialysis systolic blood pressure correlates strongly with mean 24-hour systolic blood pressure and left ventricular mass in stable hemodialysis patients.

1996 ◽  
Vol 7 (12) ◽  
pp. 2658-2663
Author(s):  
P J Conion ◽  
J J Walshe ◽  
S K Heinle ◽  
S Minda ◽  
M Krucoff ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Left Ventricular Mass ◽  
Hemodialysis Patients ◽  
Left Ventricular ◽  
Antihypertensive Medications ◽  
Ventricular Mass ◽  
Time Period ◽  
Lv Mass ◽  
Blood Pressure Data

This study used a 24-h ambulatory blood pressure (ABP) monitor to study the relationship between dialysis room-measured blood pressures (BP) and mean 24-h systolic and diastolic ambulatory BP (SABP and DABP) with left ventricular mass (LV) in a group of 35 stable hemodialysis patients. Predialysis and postdialysis systolic and diastolic blood pressure data were collected for the 12 dialysis treatments before the wearing of the ABP device, and the means of these values are reported. All patients were maintained on the same antihypertensive medications for 3 months before the study and had a stable hematocrit value of 30 +/- 3% during this time period. There was no difference detected between daytime and nighttime ABP. SABP was a mean of 4.7 mm Hg below predialysis systolic BP (P = 0.004) and DABP was a mean of 3.7 mm Hg below predialysis diastolic BP. There was a strong correlation between SABP and predialysis systolic BP (r = 0.67, P = 0.0001); however, postdialysis diastolic BP correlated better with DABP than did predialysis diastolic BP. In addition, LV mass correlated with SABP (r = 0.35, P = 0.03) and predialysis systolic BP (r = 0.35, P = 0.03). There was no apparent correlation between either pre- or postdialysis diastolic BP with LV mass. It was concluded that predialysis systolic BP and postdialysis diastolic BP correlates strongly with SABP and DABP. Furthermore, predialysis systolic BP correlates with LV mass in hemodialysis patients. If the deleterious effects of hypertension in this patient population are to be avoided, it is the predialysis systolic BP that needs to be controlled: It is insufficient to be satisfied with good postdialysis BP control, if patients are hypertensive before beginning dialysis.

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