Pathophysiology and Clinical Importance of Hyperhomocysteinemia: Clinical Intervention Studies

1999 ◽  
Vol 25 (4-6) ◽  
pp. 286-290 ◽  
Author(s):  
Gere Sunder-Plassmann ◽  
Manuela Födinger
Keyword(s):  
Intervention Studies ◽  
Clinical Importance ◽  
Clinical Intervention

scholarly journals Monitoring strategies for clinical intervention studies

2021 ◽  
Vol 2021 (12) ◽  
Author(s):  
Katharina Klatte ◽  
Christiane Pauli-Magnus ◽  
Sharon B Love ◽  
Matthew R Sydes ◽  
Pascal Benkert ◽  
...  
Keyword(s):  
Intervention Studies ◽  
Clinical Intervention ◽  
Monitoring Strategies

A Youth-Provider Connectedness Measure For Use In Clinical Intervention Studies

2009 ◽  
Vol 44 (2) ◽  
pp. S35-S36 ◽  
Author(s):  
Sion K. Harris ◽  
Elizabeth R. Woods ◽  
Lon Sherritt ◽  
Shari Van Hook ◽  
Suzanne Boulter ◽  
...  
Keyword(s):  
Intervention Studies ◽  
Clinical Intervention

Theory-based and evidence-based design of audit and feedback programmes: examples from two clinical intervention studies

2017 ◽  
Vol 26 (4) ◽  
pp. 323-334 ◽  
Author(s):  
Sylvia J Hysong ◽  
Harrison J Kell ◽  
Laura A Petersen ◽  
Bryan A Campbell ◽  
Barbara W Trautner
Keyword(s):  
Intervention Studies ◽  
Clinical Intervention ◽  
Audit And Feedback ◽  
Evidence Based

scholarly journals Speech Outcomes of a National Cohort of Children with Orofacial Cleft at 5 and 10 Years of age

2021 ◽  
pp. 105566562110449
Author(s):  
Maeve M. Morrison ◽  
Nicola T. Mason ◽  
Bryony L. Forde ◽  
Peter R. Stone ◽  
Peter V. Fowler ◽  
...  
Keyword(s):  
New Zealand ◽  
Cleft Lip ◽  
Sound Production ◽  
Cleft Lip And Palate ◽  
Age Groups ◽  
Significant Proportion ◽  
Clinical Importance ◽  
Clinical Intervention ◽  
Orofacial Cleft ◽  
Velopharyngeal Function

Objective To assess speech outcomes at five and ten years of age in a nationwide study of children with orofacial cleft. Design Prospective study. Participants Children born with orofacial cleft and having primary surgery in New Zealand. Speech samples were available for 151 five-year-old, and 163 ten-year-old children. Main outcome measures Intelligibility, Acceptability, Velopharyngeal function, Hypernasality, Hyponasality, severity of airflow evaluated by perceptual speech assessment (using the standardised Rhinocleft assessment), and overall assessment of requirement for clinical intervention. Results A large proportion of five-year-old children had speech that was considered to be not completely intelligible, was not acceptable, and had inadequate velopharyngeal function. The noted deficiencies led to a clinical judgement that further speech and/or surgical intervention was required in 85% with cleft lip and palate, 65% with cleft palate and 26% with cleft lip. The proportion of children with poor speech outcomes in the ten-year-old children was lower, though of clinical importance, further intervention required for 25% with CLP, 15% with CP and 3% with CL. The number of sound production errors in both age groups followed the same pattern with fewest in those with CL and most in those with CLP. Conclusions A significant proportion of children with orofacial cleft were found to have poor speech outcomes requiring further treatment. The outcomes are poor compared to centres reported in the UK and Scandinavia. New Zealand requires a review of the current services for individuals born with cleft to improve speech outcomes and interdisciplinary care.

Does evidence support physiotherapy management of adult female chronic pelvic pain? A systematic review

2012 ◽  
Vol 3 (2) ◽  
pp. 70-81 ◽  
Author(s):  
S. Loving ◽  
J. Nordling ◽  
P. Jaszczak ◽  
T. Thomsen
Keyword(s):  
Clinical Trials ◽  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Intervention Studies ◽  
Clinical Intervention ◽  
Evidence Base ◽  
Risk Of Bias ◽  
Randomised Clinical Trials ◽  
Multidisciplinary Intervention

AbstractBackground and purposeChronic pelvic pain (CPP) is a debilitating condition among women with a major impact on health-related quality of life, work productivity and health care utilisation. The exact prevalence of chronic pelvic pain is not known, but 3.8% is commonly suggested. Musculoskeletal dysfunction is frequently cited as a possible aetiology. Physiotherapy is therefore recommended as one treatment modality. The aim of this systematic review was to source and critically evaluate the evidence for an effect of physiotherapy on pain, physical activity and quality of life in the treatment of female CPP.MethodsElectronic databases, conference proceedings, text books and clinical guidelines were searched for quantitative, observational, and prospective clinical intervention studies of female chronic pelvic pain where physiotherapy was a sole or significant component of the intervention. Trial inclusion, data extraction according to predefined criteria and risk of bias assessment were performed by two independent authors. Methodological quality of the included clinical intervention studies was assessed using The Cochrane Collaboration’s tool for assessing risk of bias. Review Manager (RevMan) version 5.0 was used for data analysis. Effect estimates (relative risk, mean difference and mean change) with 95% confidence intervals were calculated for the above outcomes. For significant outcomes the numbers needed to treat were calculated.ResultsThe search strategy identified 3469 potential articles. Of these, 11 articles, representing 10 studies, met the inclusion criteria. There were 6 randomised clinical trials, 1 cohort study and 3 case series. Methodological quality was dependent on study type. Accordingly, level of evidence was judged higher in randomised clinical trials than in the other study types. Physiotherapy treatments varied between studies and were provided in combination with psychotherapeutic modalities and medical management. This did not allow for the ‘stand-alone’ value of physiotherapy to be determined. Heterogeneity across the studies, with respect to participants, interventions, outcome measures and times of follow-up, prevented meta-analysis. Narrative synthesis of the results, based on effect estimates and clinically relevant pain improvement, disclosed some evidence to support an effect of multidisciplinary intervention and Mensendieck somatocognitive therapy on female chronic pelvic pain.ConclusionChronic pelvic pain in women is a major health care problem with no specific therapies and poor prognosis. There seems to be some evidence to support the use of a multidisciplinary intervention in the management of female chronic pelvic pain. Somatocognitive therapy is a new approach that appears to be promising and randomised clinical trials are underway in order to establish its evidence base.ImplicationsBased on the findings of this review, recommendations for physiotherapy in chronic pelvic pain clinical guidelines, textbooks and narrative reviews should be interpreted with caution due to the lack of a sufficient evidence base. Only small and largely non-randomised studies have been undertaken of physiotherapeutic interventions and this greatly limits the available evidence on which to base clinical practice. High quality randomised clinical trials are therefore urgently needed.

scholarly journals Monitoring strategies for clinical intervention studies

2019 ◽  
Author(s):  
Katharina Klatte ◽  
Christiane Pauli-Magnus ◽  
Sharon Love ◽  
Matthew Sydes ◽  
Pascal Benkert ◽  
...  
Keyword(s):  
Intervention Studies ◽  
Clinical Intervention ◽  
Monitoring Strategies

Five Features to Look for in Early-Phase Clinical Intervention Studies

2020 ◽  
Vol 35 (1) ◽  
pp. 3-9
Author(s):  
Jonathan S. Tsay ◽  
Carolee J. Winstein
Keyword(s):  
Early Phase ◽  
Intervention Studies ◽  
Clinical Decision Making ◽  
Clinical Intervention ◽  
Daily Practice ◽  
Stroke Care ◽  
Clinical Decision ◽  
Balance Sheets ◽  
Neural Connections ◽  
Busy Clinician

Neurorehabilitation relies on core principles of neuroplasticity to activate and engage latent neural connections, promote detour circuits, and reverse impairments. Clinical interventions incorporating these principles have been shown to promote recovery and demote compensation. However, many clinicians struggle to find interventions centered on these principles in our nascent, rapidly growing body of literature. Not to mention the immense pressure from regulatory bodies and organizational balance sheets that further discourage time-intensive recovery-promoting interventions, incentivizing clinicians to prioritize practical constraints over sound clinical decision making. Modern neurorehabilitation practices that result from these pressures favor strategies that encourage compensation over those that promote recovery. To narrow the gap between the busy clinician and the cutting-edge motor recovery literature, we distilled 5 features found in early-phase clinical intervention studies—ones that value the more enduring biological recovery processes over the more immediate compensatory remedies. Filtering emerging literature through this lens and routinely integrating promising research into daily practice can break down practical barriers for effective clinical translation and ultimately promote durable long-term outcomes. This perspective is meant to serve a new generation of mechanistically minded and caring clinicians, students, activists, and research trainees, who are poised to not only advance rehabilitation science, but also erect evidence-based policy changes to accelerate recovery-based stroke care.

scholarly journals Why epidemiological and clinical intervention studies often give different or diverging results?

IUBMB Life ◽  
2009 ◽  
Vol 61 (4) ◽  
pp. 391-393 ◽  
Author(s):  
Henrik E. Poulsen ◽  
Jon Traerup Andersen ◽  
Niels Keiding ◽  
Tina Ken Schramm ◽  
Rikke Sørensen ◽  
...  
Keyword(s):  
Intervention Studies ◽  
Clinical Intervention
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