Effects of a Meat Meal on Renal Sodium Handling and Sodium Balance

1998 ◽  
Vol 24 (4) ◽  
pp. 279-284 ◽  
Author(s):  
Massimo Cirillo ◽  
Pietro Anastasio ◽  
Lucia Spitali ◽  
Domenico Santoro ◽  
Natale G. De Santo
Keyword(s):  
Sodium Balance ◽  
Meat Meal ◽  
Renal Sodium Handling ◽  
Sodium Handling

scholarly journals Contrasting Effects of Vasodilators on Blood Pressure and Sodium Balance in the Hypertension of Autonomic Failure

1999 ◽  
Vol 10 (1) ◽  
pp. 35-42 ◽  
Author(s):  
JENS JORDAN ◽  
JOHN R. SHANNON ◽  
BOJAN POHAR ◽  
SACHIN Y. PARANJAPE ◽  
DAVID ROBERTSON ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Orthostatic Hypotension ◽  
Autonomic Failure ◽  
Sodium Balance ◽  
Orthostatic Tolerance ◽  
Supine Hypertension ◽  
Renal Sodium Handling ◽  
Pressure Natriuresis ◽  
Depressor Effect ◽  
Sodium Handling

Abstract. Supine hypertension, which is very common in patients with autonomic failure, limits the use of pressor agents and induces nighttime natriuresis. In 13 patients with severe orthostatic hypotension due to autonomic failure (7 women, 6 men, 72 ± 3 yr) and supine hypertension, the effect of 30 mg nifedipine (n = 10) and 0.025 to 0.2 mg/h nitroglycerin patch (n = 11) on supine BP, renal sodium handling, and orthostatic tolerance was determined. Medications were given at 8 p.m.; patients stood up at 8 a.m. Nitroglycerin was removed at 6 a.m. Compared with placebo, nifedipine and nitroglycerin decreased systolic BP during the night by a maximum of 37 ± 9 and 36 ± 10 mmHg, respectively (P < 0.01). At 8 a.m., supine systolic BP was 23 ± 7 mmHg lower with nifedipine than with placebo (P < 0.05), but was similar with nitroglycerin and placebo. Sodium excretion during the night was not reduced with nitroglycerin (0.13 ± 0.02 mmol/mg creatinine [Cr] versus 0.15 ± 0.03 mmol/mg Cr with placebo), but it was increased with nifedipine (0.35 ± 0.06 mmol/mg Cr versus 0.13 ± 0.02 mmol/mg Cr with placebo, P < 0.05). Nifedipine but not nitroglycerin worsened orthostatic hypotension in the morning. It is concluded that nifedipine and transdermal nitroglycerin are effective in controlling supine hypertension in patients with autonomic failure. However, nifedipine has a prolonged depressor effect and worsens orthostatic hypotension in the morning. The decrease in pressure natriuresis that would be expected with the substantial decrease in BP obtained with nitroglycerin and nifedipine may be offset by a direct effect of both drugs on renal sodium handling.

Sodium retention after adrenal enucleation

1986 ◽  
Vol 250 (1) ◽  
pp. E1-E12 ◽  
Author(s):  
R. D. Perrone ◽  
H. H. Bengele ◽  
E. A. Alexander
Keyword(s):  
Adrenal Gland ◽  
Urinary Excretion ◽  
Adrenal Cortex ◽  
Plasma Levels ◽  
Sodium Balance ◽  
Sodium Retention ◽  
Steroid Production ◽  
Adrenal Steroid ◽  
Renal Sodium Handling ◽  
Sodium Handling

Adrenal enucleation (removal of the adrenal gland, leaving the capsule intact) results in regeneration of the adrenal cortex. During the first 1-2 wk of adrenal regeneration, marked renal sodium avidity and positive sodium balance are noted. This renal sodium avidity appears mediated via adrenocorticotropin-stimulated secretion of a potent mineralocorticoid by the regenerating adrenal cortex. In this review, we have examined relationships between the histology and ultrastructure of the regenerating adrenal cortex, renal sodium handling, and adrenal steroid production at various times after the initiation of adrenal regeneration. Plasma levels of known mineralocorticoids are subnormal during the period of most intense sodium avidity, while urinary excretion of a potent mineralocorticoid, 19-nordeoxycorticosterone, has been found to be increased in rats with regenerating adrenals during this period of most intense sodium avidity. This hormone, however, is not elevated in rats with regenerating adrenals after resolution of the period of sodium avidity. In this article, we review the experimental evidence regarding the potency of this mineralocorticoid and its likely role in the sodium retention after adrenal enucleation.

Renal sodium handling in acute and chronic salt loading/depletion protocols

2000 ◽  
Vol 18 (11) ◽  
pp. 1657-1664 ◽  
Author(s):  
Michel Burnier ◽  
Marie-Laure Monod ◽  
Arnaud Chioléro ◽  
Marc Maillard ◽  
Jurg Nussberger ◽  
...  
Keyword(s):  
Salt Loading ◽  
Renal Sodium Handling ◽  
Sodium Handling

Renal Sodium Handling in Relation to Environmental and Genetic Factors in Untreated Chinese

2020 ◽  
Author(s):  
Yuan-Yuan Kang ◽  
Yi-Bang Cheng ◽  
Qian-Hui Guo ◽  
Chang-Sheng Sheng ◽  
Qi-Fang Huang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Multiple Testing ◽  
Genetic Factors ◽  
Blood Pressure Monitoring ◽  
Lithium Concentration ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Renal Sodium Handling ◽  
Renal Tubular ◽  
Sodium Handling

Abstract Background We investigated proximal and distal renal tubular sodium handling, as assessed by fractional excretion of lithium (FELi) and fractional distal reabsorption rate of sodium (FDRNa), in relation to environmental and genetic factors in untreated patients. Methods Our study participants were suspected hypertensive patients being off antihypertensive medication for ≥2 weeks and referred for 24-hour ambulatory blood pressure monitoring. We collected serum and 24-hour urine for measurement of sodium, creatinine and lithium concentration, and calculated FELi and FDRNa. We genotyped 19 SNPs associated with renal sodium handling or blood pressure using the ABI SNapShot method. Results The 1409 participants (664 men, 47.1%) had a mean (±SD) age of 51.0±10.5 years. After adjustment for host factors, both FELi and FDRNa were significantly (P≤0.01) associated with season and humidity, explaining ~1.3% and ~3.5% of the variance, respectively. FELi was highest in autumn and lowest in summer and intermediate in spring and winter (P=0.007). FDRNa was also highest in autumn but lowest in winter and intermediate in spring and summer (P&lt;0.001). Neither FELi nor FDRNa was associated with outdoor temperature or atmospheric pressure (P≥0.13). After adjustment for host and environmental factors and Bonferroni multiple testing, among the 19 studied genetic variants, only rs12513375 was significantly associated with FELi and FDRNa (P≤0.004) and explained about 1.7% of the variance. Conclusions Renal sodium handling as measured by endogenous lithium clearance was sensitive to major environmental and genetic factors. Our finding is towards the use of these indexes for the definition of renal tubular dysfunction.

Effects of insulin and lipid emulsion on renal haemodynamics and renal sodium handling in IDDM patients

Diabetologia ◽  
1996 ◽  
Vol 39 (9) ◽  
pp. 1074-1082 ◽  
Author(s):  
T. Pelikánová ◽  
I. Smrčková ◽  
J. KŘíŽová ◽  
J. StŘíbrná ◽  
V. Lánská
Keyword(s):  
Lipid Emulsion ◽  
Renal Haemodynamics ◽  
Renal Sodium Handling ◽  
Sodium Handling

Antioxidant treatment normalizes nitric oxide production, renal sodium handling and blood pressure in experimental hyperleptinemia

Life Sciences ◽  
2005 ◽  
Vol 77 (15) ◽  
pp. 1855-1868 ◽  
Author(s):  
Jerzy Beltowski ◽  
Grażyna Wójcicka ◽  
Anna Jamroz-Wiśniewska ◽  
Ewelina Borkowska ◽  
Andrzej Marciniak
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Nitric Oxide Production ◽  
Antioxidant Treatment ◽  
Oxide Production ◽  
Renal Sodium Handling ◽  
Sodium Handling

Renal sodium handling abnormalities in hypertensive and normotensive patients with a family history of hypertension

1989 ◽  
Vol 7 ◽  
pp. S178-179 ◽  
Author(s):  
Agustin J. Ramirez ◽  
Maria I. Gimenez ◽  
Javier Gallo ◽  
Enrique J. Marco ◽  
Ramiro A. Sanchez
Keyword(s):  
Family History ◽  
History Of ◽  
Family History Of Hypertension ◽  
Renal Sodium Handling ◽  
Sodium Handling
Sign in / Sign up

Export Citation Format

Share Document