Role of Estrogen and Estrogen-Related Growth Factor in the Mechanism of Hormone Dependency of Endometrial Carcinoma Cells

Oncology ◽  
1998 ◽  
Vol 55 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Hiroki Hata ◽  
Mieko Hamano ◽  
Jun Watanabe ◽  
Hiroyuki Kuramoto
Keyword(s):  
Growth Factor ◽  
Endometrial Carcinoma ◽  
Carcinoma Cells ◽  
Hormone Dependency

The role of Ha-ras oncogenes in growth factor independence in rat mammary carcinoma cells

1991 ◽  
Vol 4 (4) ◽  
pp. 286-296 ◽  
Author(s):  
Caterina Chiodino ◽  
Richard F. Jones ◽  
Stephen P. Ethier
Keyword(s):  
Growth Factor ◽  
Mammary Carcinoma ◽  
Carcinoma Cells ◽  
Mammary Carcinoma Cells ◽  
Ras Oncogenes

scholarly journals Transforming Growth Factor-β3 Increases the Invasiveness of Endometrial Carcinoma Cells through Phosphatidylinositol 3-Kinase-dependent Up-regulation of X-linked Inhibitor of Apoptosis and Protein Kinase C-dependent Induction of Matrix Metalloproteinase-9

2006 ◽  
Vol 282 (7) ◽  
pp. 4794-4802 ◽  
Author(s):  
Céline Van Themsche ◽  
Isabelle Mathieu ◽  
Sophie Parent ◽  
Eric Asselin
Keyword(s):  
Protein Kinase C ◽  
Growth Factor ◽  
Endometrial Carcinoma ◽  
Transforming Growth Factor ◽  
Carcinoma Cells ◽  
Inhibitor Of Apoptosis ◽  
Phosphatidylinositol 3 Kinase ◽  
Kinase C ◽  
Apoptotic Effects ◽  
Metalloproteinase 9

Tumor cells often acquire intrinsic resistance to the growth inhibitory and pro-apoptotic effects of transforming growth factor-β (TGF-β); moreover, TGF-β can confer invasive properties to established tumor cells. In the present study, we show that TGF-β isoforms (TGF-β1, TGF-β2, and TGF-β3) trigger proper Smad signaling in human endometrial carcinoma cell lines and efficiently inhibit cellular proliferation. These cells, however, exhibit a high degree of resistance to TGF-β pro-apoptotic effects; we found that this resistant phenotype would be acquired through up-regulation of X-linked inhibitor of apoptosis protein (XIAP) levels. In addition, using RNA interference and pharmacological inhibitors, we show that TGF-β increases cellular invasiveness via two distinct signaling pathways in endometrial carcinoma cells: phosphatidylinositol 3-kinase/AKT-dependent up-regulation of XIAP and protein kinase C-dependent induction of matrix-metalloproteinase-9 (MMP-9) expression. Additionally, these findings were correlated with clinical observations showing abundant TGF-β immunoreactivity in human endometrial carcinoma tumors in vivo, extending from the epithelial compartment to the stroma upon acquisition of an invasive phenotype (gradually from grades I to III). Collectively our results describe for the first time a role for TGF-β3 in tumor invasiveness.

scholarly journals Role of the aging vasculature andErb B-2 signaling in epidermal growth factor-dependent intravasion of breast carcinoma cells

Cancer ◽  
2004 ◽  
Vol 101 (1) ◽  
pp. 198-205 ◽  
Author(s):  
Daniel J. Price ◽  
Shalom Avraham ◽  
Shuxian Jiang ◽  
Yigong Fu ◽  
Hava Karsenty Avraham
Keyword(s):  
Growth Factor ◽  
Breast Carcinoma ◽  
Epidermal Growth Factor ◽  
Carcinoma Cells ◽  
Breast Carcinoma Cells ◽  
Epidermal Growth
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