Environmental Risk Factors for Amyotrophic Lateral Sclerosis

2001 ◽  
Vol 20 (1) ◽  
pp. 2-6 ◽  
Author(s):  
Carmel Armon
Keyword(s):  
Risk Factors ◽  
Amyotrophic Lateral Sclerosis ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Lateral Sclerosis

scholarly journals Environmental Risk Factors and Amyotrophic Lateral Sclerosis: An Umbrella Review and Critical Assessment of Current Evidence from Systematic Reviews and Meta-Analyses of Observational Studies

2016 ◽  
Vol 46 (2) ◽  
pp. 96-105 ◽  
Author(s):  
Lazaros Belbasis ◽  
Vanesa Bellou ◽  
Evangelos Evangelou
Keyword(s):  
Risk Factors ◽  
Amyotrophic Lateral Sclerosis ◽  
Environmental Factors ◽  
Random Effects ◽  
Systematic Reviews ◽  
Environmental Risk ◽  
Observational Studies ◽  
Environmental Risk Factors ◽  
Meta Analyses ◽  
Lateral Sclerosis

Background: The pathogenesis of amyotrophic lateral sclerosis (ALS) involves both environmental and genetic factors. Our study aimed at summarising the environmental risk factors for ALS, assessing the evidence for diverse biases, and pinpointing risk factors with high epidemiological credibility. Methods: We searched PubMed from inception to August 20, 2015, to identify systematic reviews and meta-analyses of observational studies examining associations between environmental factors and ALS. For each meta-analysis, we estimated the summary effect size by the use of random-effects and fixed-effects models, the 95% CI, the 95% prediction interval (PI), and the between-study heterogeneity. We assessed the evidence of small-study effects and excess significance bias. Results: Sixteen unique meta-analyses of different risk factors and ALS were considered. Of them, 5 were statistically significant at p < 0.001 under the random-effects model. Only one factor presented robust evidence for a convincing association. This association pertained to chronic occupational exposure to lead (random-effects OR 1.81, 95% CI 1.39-2.35). Conclusions: A small number of published meta-analyses on environmental factors and risk of ALS was identified, a phenomenon that could be attributed to the challenges in studying a rare neurological disease. More observational studies with adequate sample size and study design are needed to clarify the environmental component of ALS pathogenesis.

scholarly journals Environmental Risk Factors and Amyotrophic Lateral Sclerosis (ALS): A Case-Control Study of ALS in Michigan

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e101186 ◽  
Author(s):  
Yu Yu ◽  
Feng-Chiao Su ◽  
Brian C. Callaghan ◽  
Stephen A. Goutman ◽  
Stuart A. Batterman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Amyotrophic Lateral Sclerosis ◽  
Environmental Risk ◽  
Case Control Study ◽  
Case Control ◽  
Environmental Risk Factors ◽  
Control Study ◽  
Lateral Sclerosis

scholarly journals What causes amyotrophic lateral sclerosis?

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 371 ◽  
Author(s):  
Sarah Martin ◽  
Ahmad Al Khleifat ◽  
Ammar Al-Chalabi
Keyword(s):  
Risk Factors ◽  
Amyotrophic Lateral Sclerosis ◽  
Respiratory Failure ◽  
Neurodegenerative Disease ◽  
Motor Neurons ◽  
Environmental Risk ◽  
Age Of Onset ◽  
Genetic Associations ◽  
Male Predominance ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis is a neurodegenerative disease predominantly affecting upper and lower motor neurons, resulting in progressive paralysis and death from respiratory failure within 2 to 3 years. The peak age of onset is 55 to 70 years, with a male predominance. The causes of amyotrophic lateral sclerosis are only partly known, but they include some environmental risk factors as well as several genes that have been identified as harbouring disease-associated variation. Here we review the nature, epidemiology, genetic associations, and environmental exposures associated with amyotrophic lateral sclerosis.

Self-Control As a Moderator for Environmental Risk Factors

2010 ◽  
Author(s):  
Thomas A. Wills ◽  
Pallav Pokhrel ◽  
Frederick X. Gibbons ◽  
James D. Sargent ◽  
Mike Stoolmiller
Keyword(s):  
Risk Factors ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Self Control

Environmental Risk Factors in Multiple Sclerosis Questionnaire

2012 ◽  
Author(s):  
M. Pugliatti ◽  
I. Casetta ◽  
J. Drulovic ◽  
E. Granieri ◽  
T. Holmøy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Environmental Risk ◽  
Environmental Risk Factors
Sign in / Sign up

Export Citation Format

Share Document