Effect of Long-Term Treatment with the Antiestrogen EM-652.HCl on Pituitary Estrogen Receptor Alpha and Prolactin mRNA Expression in Intact, Ovariectomized and Gonadotropin- Releasing Hormone-Treated Female Rats

2001 ◽  
Vol 74 (6) ◽  
pp. 367-374 ◽  
Author(s):  
Georges Pelletier ◽  
Mohamed El-Alfy ◽  
Claude Labrie ◽  
Céline Martel ◽  
Fernand Labrie
Keyword(s):  
Estrogen Receptor ◽  
Mrna Expression ◽  
Estrogen Receptor Alpha ◽  
Term Treatment ◽  
Gonadotropin Releasing Hormone ◽  
Female Rats ◽  
Receptor Alpha ◽  
Long Term Treatment ◽  
Prolactin Mrna

Long-term treatment with angiotensin II type 1 receptor antagonist, CV-11974, restores β-catenin mRNA expression in volume-overloaded rabbit hearts

2002 ◽  
Vol 17 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Makoto Itoh ◽  
Y. Takeishi ◽  
Shigekazu Nakada ◽  
Takuya Miyamoto ◽  
Yuichi Tsunoda ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Mrna Expression ◽  
Term Treatment ◽  
Long Term Treatment

Aromatase and estrogen receptor alpha mRNA expression as prognostic biomarkers in patients with astrocytomas

2014 ◽  
Vol 119 (2) ◽  
pp. 275-284 ◽  
Author(s):  
J. M. Dueñas Jiménez ◽  
A. Candanedo Arellano ◽  
A. Santerre ◽  
S. Orozco Suárez ◽  
H. Sandoval Sánchez ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Mrna Expression ◽  
Estrogen Receptor Alpha ◽  
Prognostic Biomarkers ◽  
Receptor Alpha

Abstract P053: Enhanced Exercise Capacity By Muscadine Grape Extract Treatment Is Only Evident In Older Hypertensive Female Rats And Is Independent Of Blood Pressure

Hypertension ◽  
2020 ◽  
Vol 76 (Suppl_1) ◽  
Author(s):  
Nildris Cruz Diaz ◽  
A'ja V Duncan ◽  
Wayne Graham ◽  
Brian Westwood ◽  
Patricia E. Gallagher ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Exercise Capacity ◽  
Physical Performance ◽  
Term Treatment ◽  
Female Rats ◽  
Sprague Dawley ◽  
Grape Extract ◽  
Long Term Treatment ◽  
Muscadine Grape

Physical performance and systolic blood pressure (SBP) during aging in normotensive female Sprague-Dawley (SD) and hypertensive (mRen2)27 transgenic rats were assessed following long-term treatment with a Muscadine Grape Extract (MGE, Piedmont Research and Development Corp). MGE was administered at a dose of 0.2 mg/mL in the drinking water starting at 14 weeks (wks) of age with an endpoint at 70 wks of age (total time of treatment of 56 wks). At 20-, 40- and 70-wks of age, physical performance (exercise capacity in seconds and workload in grams - meters) was determined using a treadmill at a velocity of 17 cm/second with a 5% incline. SBP was determined by tail-cuff plethysmography in trained rats. There were no significant differences in physical performance between SD and (mRen2)27 female rats at any age despite the higher SBP in the (mRen2)27 rats at all ages. Long-term treatment with MGE had no significant effect on physical performance or SBP in SD rats at any age. In contrast, MGE treatment markedly increased exercise capacity (40 wks: 1615 ± 166 vs 4943 ± 442 seconds, p<0.01, n = 4-9; 70 wks: 2520 ± 374 vs 4117 ± 245 seconds, p<0.01, n = 4-8) and workload (40 wks: 4579 ± 490 vs 14730 ± 1353 grams - meters, p<0.01, n = 4-9; 70 wks: 8338 ± 1340 vs 13659 ± 933 grams - meters, p<0.01, n = 4-8) at the later ages in female (mRen2)27 rats, while there was no effect on SBP (20 wks: 167 ± 4 vs 173 ± 4 mm Hg, n = 4-6; 40 wks: 177 ± 8 vs 170 ± 7 mm Hg, n = 6-7; 70 wks:154 ± 6 vs 172 ± 6 mm Hg, n = 5) at any age. These data suggest that MGE treatment is effective in improving physical performance only in hypertensive female rats and may be independent of changes in blood pressure. The benefit of MGE in the older hypertensive female may reflect reductions in vascular stiffness and oxidative stress. Support: Chronic Disease Research Fund, Hypertension & Vascular Research Center

INFLUENCE OF GONADAL HORMONES ON THE ACTION OF CALCITONIN IN THE RAT

1971 ◽  
Vol 68 (3) ◽  
pp. 585-596 ◽  
Author(s):  
O. Helmer Serensen ◽  
Inge Hindberg
Keyword(s):  
Serum Calcium ◽  
Thyroid Tissue ◽  
Gonadal Hormones ◽  
Term Treatment ◽  
Female Rats ◽  
Short Term ◽  
Oestrogen Treatment ◽  
Male And Female Rats ◽  
Long Term Treatment

ABSTRACT The influence of short-term and long-term treatment with gonadal hormones on the response to calcitonin was investigated in the rat. Oestrogen-treatment, short-term as well as long-term, resulted in a reduced responsiveness to calcitonin. Long-term treatment with androgens enhanced the hypocalcaemic effect of calcitonin in castrated rats of either sex, but reduced the effect in intact animals. No sex differences could be registered in the sensitivity to calcitonin, when intact animals were compared according to age, while marked differences were observed, when the animals were compared according to weight. There was a linear decrease in the response to calcitonin with increasing age in rats of both sexes. An intraperitoneal calcium load was followed by an acute rise in the serum calcium levels. The adult animals counteracted the hypercalcaemia more slowly than the young ones. Significant differences also occurred between male and female rats, the rise in the serum calcium concentration being much more pronounced in the latter group. The hypocalcaemic activity of thyroid tissue from rats of both sexes and of various ages showed considerable variations, but no differences correlated to age or sex.

scholarly journals Lipid-Lowering Effects of Tetradecylthioacetic Acid in Antipsychotic-Exposed, Female Rats: Challenges with Long-Term Treatment

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e50853 ◽  
Author(s):  
Silje Skrede ◽  
Johan Fernø ◽  
Bodil Bjørndal ◽  
Wenche Rødseth Brede ◽  
Pavol Bohov ◽  
...  
Keyword(s):  
Term Treatment ◽  
Female Rats ◽  
Lipid Lowering ◽  
Tetradecylthioacetic Acid ◽  
Long Term Treatment
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