Progesterone Prevents Estradiol-Induced Dendritic Spine Formation in Cultured Hippocampal Neurons

2000 ◽  
Vol 72 (3) ◽  
pp. 133-143 ◽  
Author(s):  
Diane D. Murphy ◽  
Menahem Segal
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Spine Formation ◽  
Cultured Hippocampal Neurons

scholarly journals Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation

2013 ◽  
Vol 24 (10) ◽  
pp. 1602-1613 ◽  
Author(s):  
Shuhei Ueda ◽  
Manabu Negishi ◽  
Hironori Katoh
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Molecular Mechanisms ◽  
Neuronal Development ◽  
Actin Binding ◽  
Spine Density ◽  
Nucleotide Exchange ◽  
Spine Formation ◽  
Nucleotide Exchange Factor ◽  
Important Interaction

In neuronal development, dendritic spine formation is important for the establishment of excitatory synaptic connectivity and functional neural circuits. Developmental deficiency in spine formation results in multiple neuropsychiatric disorders. Dock4, a guanine nucleotide exchange factor (GEF) for Rac, has been reported as a candidate genetic risk factor for autism, dyslexia, and schizophrenia. We previously showed that Dock4 is expressed in hippocampal neurons. However, the functions of Dock4 in hippocampal neurons and the underlying molecular mechanisms are poorly understood. Here we show that Dock4 is highly concentrated in dendritic spines and implicated in spine formation via interaction with the actin-binding protein cortactin. In cultured neurons, short hairpin RNA (shRNA)–mediated knockdown of Dock4 reduces dendritic spine density, which is rescued by coexpression of shRNA-resistant wild-type Dock4 but not by a GEF-deficient mutant of Dock4 or a truncated mutant lacking the cortactin-binding region. On the other hand, knockdown of cortactin suppresses Dock4-mediated spine formation. Taken together, the results show a novel and functionally important interaction between Dock4 and cortactin for regulating dendritic spine formation via activation of Rac.

scholarly journals Nicotine induces dendritic spine remodeling in cultured hippocampal neurons

2013 ◽  
Vol 128 (2) ◽  
pp. 246-255 ◽  
Author(s):  
Akira Oda ◽  
Kanato Yamagata ◽  
Saya Nakagomi ◽  
Hiroshi Uejima ◽  
Pattama Wiriyasermkul ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Cultured Hippocampal Neurons

Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons

2009 ◽  
Vol 122 (4) ◽  
pp. 524-534 ◽  
Author(s):  
A. Ivanov ◽  
M. Esclapez ◽  
C. Pellegrino ◽  
T. Shirao ◽  
L. Ferhat
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Synaptic Function ◽  
Spine Plasticity ◽  
Cultured Hippocampal Neurons

The Rac activator Dock4 regulates dendritic spine formation in hippocampal neurons

2011 ◽  
Vol 71 ◽  
pp. e336
Author(s):  
Shuhei Ueda ◽  
Manabu Negishi ◽  
Hironori Katoh
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Spine Formation

Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons

2005 ◽  
Vol 8 (2) ◽  
pp. 164-172 ◽  
Author(s):  
Yuanyuan Ji ◽  
Petti T Pang ◽  
Linyin Feng ◽  
Bai Lu
Keyword(s):  
Cyclic Amp ◽  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Spine Formation
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