Neuropeptide Y Innervation and Neuropeptide-Y-Y1-Receptor-Expressing Neurons in the Paraventricular Hypothalamic Nucleus of the Mouse

1999 ◽  
Vol 70 (5) ◽  
pp. 295-305 ◽  
Author(s):  
Christian Broberger ◽  
Theo J. Visser ◽  
Michael J. Kuhar ◽  
Tomas Hökfelt
1992 ◽  
Vol 575 (2) ◽  
pp. 265-271 ◽  
Author(s):  
Emilio Merlo Pich ◽  
Beatrice Messori ◽  
Michele Zoli ◽  
Francesco Ferraguti ◽  
Paolo Marrama ◽  
...  

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Shengjie Fan ◽  
Janani Dakshinamoorthy ◽  
Eun Ran Kim ◽  
Yong Xu ◽  
Cheng Huang ◽  
...  

2000 ◽  
Vol 279 (3) ◽  
pp. R1025-R1034 ◽  
Author(s):  
Yuwaraj K. Narnaware ◽  
Pierre P. Peyon ◽  
Xinwei Lin ◽  
Richard E. Peter

In mammals, neuropeptide Y (NPY) is a potent orexigenic factor. In the present study, third brain ventricle (intracerebroventricular) injection of goldfish NPY (gNPY) caused a dose-dependent increase in food intake in goldfish, and intracerebroventricular administration of NPY Y1-receptor antagonist BIBP-3226 decreased food intake; the actions of gNPY were blocked by simultaneous injection of BIBP-3226. Goldfish maintained on a daily scheduled feeding regimen display an increase in NPY mRNA levels in the telencephalon-preoptic area and hypothalamus shortly before feeding; however, a decrease occured in optic tectum-thalamus. In both fed and unfed fish, brain NPY mRNA levels decreased after scheduled feeding. Restriction in daily food ration intake for 1 wk or food deprivation for 72 h resulted in increased brain NPY mRNA levels. Results from these studies demonstrate that NPY is a physiological brain signal involved in feeding behavior in goldfish, mediating its effects, at least in part, through Y1-like receptors in the brain.


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