Influence of Cellular Energy Metabolism on Contractions of Porcine Carotid Artery Smooth Muscle

2000 ◽  
Vol 37 (6) ◽  
pp. 532-539 ◽  
Author(s):  
Patrick F. Dillon
Keyword(s):  
Smooth Muscle ◽  
Energy Metabolism ◽  
Carotid Artery ◽  
Cellular Energy ◽  
Cellular Energy Metabolism ◽  
Porcine Carotid Artery

Fatty acid, tricarboxylic acid cycle metabolites, and energy metabolism in vascular smooth muscle

1994 ◽  
Vol 267 (2) ◽  
pp. H764-H769 ◽  
Author(s):  
J. T. Barron ◽  
S. J. Kopp ◽  
J. Tow ◽  
J. E. Parrillo
Keyword(s):  
Smooth Muscle ◽  
Fatty Acid ◽  
Energy Metabolism ◽  
Carotid Artery ◽  
Vascular Smooth Muscle ◽  
Lactate Production ◽  
Tca Cycle ◽  
High Energy ◽  
Tricarboxylic Acid ◽  
O2 Consumption

The influence of octanoate on O2 consumption, tricarboxylic acid (TCA) cycle intermediates, and high-energy phosphates was examined in intact resting porcine carotid artery to investigate the role of fatty acid in energy metabolism and its integration with glucose metabolism in vascular smooth muscle. Incubation of resting arteries with octanoate (0.5 mM), which was previously shown to inhibit aerobic glycolysis (6), inhibited lactate production by 64% and increased O2 consumption by 30%. The increase in O2 consumption with octanoate was approximately equal to that calculated to account for the ATP production lost by inhibition of aerobic lactate production by octanoate. In glucose-free medium, the level of high-energy phosphate was reduced but was restored when octanoate was included in the incubation medium. This was associated with an increase in O2 consumption. These results suggest that the energy requirements of resting carotid artery can be largely met by the oxidative metabolism of fatty acid. Octanoate induced anaplerosis of the TCA cycle, as indicated by a 70% increase in the level of citrate. Extracellular glucose was necessary for octanoate-induced anaplerosis, probably by providing the extra carbon via pyruvate carboxylation, whereas a coupled transamination involving aspartate was a less important anaplerotic mechanism.

scholarly journals Glucose stimulates intestinal epithelial crypt proliferation by modulating cellular energy metabolism

2017 ◽  
Vol 233 (4) ◽  
pp. 3465-3475 ◽  
Author(s):  
Weinan Zhou ◽  
Deepti Ramachandran ◽  
Abdelhak Mansouri ◽  
Megan J. Dailey
Keyword(s):  
Energy Metabolism ◽  
Intestinal Epithelial ◽  
Cellular Energy ◽  
Cellular Energy Metabolism

scholarly journals Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis

2016 ◽  
Vol 5 (4) ◽  
pp. 283-295 ◽  
Author(s):  
Torsten Schröder ◽  
David Kucharczyk ◽  
Florian Bär ◽  
René Pagel ◽  
Stefanie Derer ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Gene Polymorphisms ◽  
Mitochondrial Gene ◽  
Cellular Energy ◽  
Cellular Energy Metabolism ◽  
Alcoholic Steatohepatitis

scholarly journals The dynamics of mitochondrial-linked gene expression among tissues and life stages in two contrasting strains of laying hens

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262613
Author(s):  
Clara Dreyling ◽  
Martin Hasselmann
Keyword(s):  
Gene Expression ◽  
Energy Metabolism ◽  
Life Span ◽  
Laying Hens ◽  
Mitochondrial Gene ◽  
Model Organisms ◽  
Life Stages ◽  
Mitochondrial Gene Expression ◽  
Cellular Energy ◽  
Cellular Energy Metabolism

The cellular energy metabolism is one of the most conserved processes, as it is present in all living organisms. Mitochondria are providing the eukaryotic cell with energy and thus their genome and gene expression has been of broad interest for a long time. Mitochondrial gene expression changes under different conditions and is regulated by genes encoded in the nucleus of the cell. In this context, little is known about non-model organisms and we provide the first large-scaled gene expression analysis of mitochondrial-linked genes in laying hens. We analysed 28 mitochondrial and nuclear genes in 100 individuals in the context of five life-stages and strain differences among five tissues. Our study showed that mitochondrial gene expression increases during the productive life span, and reacts tissue and strain specific. In addition, the strains react different to potential increased oxidative stress, resulting from the increase in mitochondrial gene expression. The results suggest that the cellular energy metabolism as part of a complex regulatory system is strongly affected by the productive life span in laying hens and thus partly comparable to model organisms. This study provides a starting point for further analyses in this field on non-model organisms, especially in laying-hens.

scholarly journals Simultaneous Multiparameter Cellular Energy Metabolism Profiling of Small Populations of Cells

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Laimonas Kelbauskas ◽  
Shashaanka P. Ashili ◽  
Kristen B. Lee ◽  
Haixin Zhu ◽  
Yanqing Tian ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Small Populations ◽  
Cellular Energy ◽  
Cellular Energy Metabolism
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