Oligoclonal Analysis of the Atopic T Cell Response to the Group 1 Allergen of Cynodon dactylon (Bermuda Grass) Pollen: Pre- and Post-Allergen-Specific Immunotherapy

2002 ◽  
Vol 127 (3) ◽  
pp. 234-244 ◽  
Author(s):  
Nirupama P. Eusebius ◽  
Lina Papalia ◽  
Cenk Suphioglu ◽  
Susan C. McLellan ◽  
Michael Varney ◽  
...  
Keyword(s):  
T Cell ◽  
Grass Pollen ◽  
Cell Response ◽  
Specific Immunotherapy ◽  
Cynodon Dactylon ◽  
T Cell Response ◽  
Bermuda Grass ◽  
Allergen Specific Immunotherapy ◽  
Bermuda Grass Pollen ◽  
Group 1

Characterization of the T Cell Response Targeting Timothy Grass Antigens in Allergic, Healthy and Specific Immunotherapy-Treated Patients

2015 ◽  
Vol 135 (2) ◽  
pp. AB277
Author(s):  
Véronique M. Schulten ◽  
Victoria Tripple ◽  
April Frazier ◽  
Rafeul Alam ◽  
David Broide ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Specific Immunotherapy ◽  
T Cell Response ◽  
Timothy Grass

Characterization of the human T cell response to rye grass pollen allergens Lol p 1 and Lol p 5

Allergy ◽  
2002 ◽  
Vol 57 (12) ◽  
pp. 1136-1144 ◽  
Author(s):  
M. D. Burton ◽  
L. Papalia ◽  
N. P. Eusebius ◽  
R. E. O'Hehir ◽  
J. M. Rolland
Keyword(s):  
T Cell ◽  
Grass Pollen ◽  
Cell Response ◽  
T Cell Response ◽  
Pollen Allergens ◽  
Rye Grass ◽  
Human T Cell

Monoclonal Antibody-Based ELISA to Quantify the Major Allergen of Cynodon dactylon (Bermuda Grass) Pollen, Cyn d 1

2004 ◽  
Vol 135 (4) ◽  
pp. 277-283 ◽  
Author(s):  
O. Duffort ◽  
B. Calabozo ◽  
R. González ◽  
J.A. Carpizo ◽  
D. Barber ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Grass Pollen ◽  
Cynodon Dactylon ◽  
Major Allergen ◽  
Bermuda Grass ◽  
Bermuda Grass Pollen

T cell response to grass pollen allergens: Correlation with skin test reactivity and serum IgE levels

1995 ◽  
Vol 73 (1) ◽  
pp. 17-22 ◽  
Author(s):  
B. BLAHER ◽  
J. McCLUSKEY ◽  
R. PUY ◽  
D. CZARNY ◽  
J. M. ROLLAND
Keyword(s):  
T Cell ◽  
Skin Test ◽  
Grass Pollen ◽  
Cell Response ◽  
T Cell Response ◽  
Pollen Allergens ◽  
Skin Test Reactivity ◽  
Serum Ige

scholarly journals Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection

2015 ◽  
Vol 89 (21) ◽  
pp. 10802-10820 ◽  
Author(s):  
Mauricio A. Martins ◽  
Damien C. Tully ◽  
Michael A. Cruz ◽  
Karen A. Power ◽  
Marlon G. Veloso de Santana ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Response ◽  
Rhesus Macaques ◽  
T Cell Responses ◽  
T Cell Response ◽  
Cell Responses ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Group 1

ABSTRACTCertain major histocompatibility complex class I (MHC-I) alleles (e.g.,HLA-B*27) are enriched among human immunodeficiency virus type 1 (HIV-1)-infected individuals who suppress viremia without treatment (termed “elite controllers” [ECs]). Likewise,Mamu-B*08expression also predisposes rhesus macaques to control simian immunodeficiency virus (SIV) replication. Given the similarities between Mamu-B*08 and HLA-B*27, SIV-infectedMamu-B*08+animals provide a model to investigate HLA-B*27-mediated elite control. We have recently shown that vaccination with three immunodominant Mamu-B*08-restricted epitopes (Vif RL8, Vif RL9, and Nef RL10) increased the incidence of elite control inMamu-B*08+macaques after challenge with the pathogenic SIVmac239 clone. Furthermore, a correlate analysis revealed that CD8+T cells targeting Nef RL10 was correlated with improved outcome. Interestingly, this epitope is conserved between SIV and HIV-1 and exhibits a delayed and atypical escape pattern. These features led us to postulate that a monotypic vaccine-induced Nef RL10-specific CD8+T-cell response would facilitate the development of elite control inMamu-B*08+animals following repeated intrarectal challenges with SIVmac239. To test this, we vaccinatedMamu-B*08+animals withnefinserts in which Nef RL10 was either left intact (group 1) or disrupted by mutations (group 2). Although monkeys in both groups mounted Nef-specific cellular responses, only those in group 1 developed Nef RL10-specific CD8+T cells. These vaccine-induced effector memory CD8+T cells did not prevent infection. Escape variants emerged rapidly in the group 1 vaccinees, and ultimately, the numbers of ECs were similar in groups 1 and 2. High-frequency vaccine-induced CD8+T cells focused on a single conserved epitope and therefore did not prevent infection or increase the incidence of elite control inMamu-B*08+macaques.IMPORTANCESince elite control of chronic-phase viremia is a classic example of an effective immune response against HIV/SIV, elucidating the basis of this phenomenon may provide useful insights into how to elicit such responses by vaccination. We have previously established that vaccine-induced CD8+T-cell responses against three immunodominant epitopes can increase the incidence of elite control in SIV-infectedMamu-B*08+rhesus macaques—a model of HLA-B*27-mediated elite control. Here, we investigated whether a monotypic vaccine-induced CD8+T-cell response targeting the conserved “late-escaping” Nef RL10 epitope can increase the incidence of elite control inMamu-B*08+monkeys. Surprisingly, vaccine-induced Nef RL10-specific CD8+T cells selected for variants within days after infection and, ultimately, did not facilitate the development of elite control. Elite control is, therefore, likely to involve CD8+T-cell responses against more than one epitope. Together, these results underscore the complexity and multidimensional nature of virologic control of lentivirus infection.

scholarly journals IL-10 and TGF-β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy

2003 ◽  
Vol 33 (5) ◽  
pp. 1205-1214 ◽  
Author(s):  
Marek Jutel ◽  
Mübeccel Akdis ◽  
Ferah Budak ◽  
Carmen Aebischer-Casaulta ◽  
Maria Wrzyszcz ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Cell Response ◽  
Specific Immunotherapy ◽  
T Cell Response

scholarly journals Dimorphism in the TCRγ-chain repertoire defines 2 types of human immunity to Epstein-Barr virus

2020 ◽  
Vol 4 (7) ◽  
pp. 1198-1205 ◽  
Author(s):  
Zakia Djaoud ◽  
Peter Parham
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Response ◽  
Nk Cell ◽  
Γδ T Cells ◽  
T Cell Response ◽  
Γδ T Cell ◽  
Barr Virus ◽  
Group 2 ◽  
Group 1

Abstract Humans form 2 groups based on their innate immunity to Epstein-Barr virus (EBV). Group 1 makes a strong natural killer (NK)–cell and γδ T-cell response, whereas group 2 makes a strong NK-cell response, but a weak γδ T-cell response. To investigate the underlying basis for this difference in γδ T-cell immunity to EBV, we used next-generation sequencing to compare the γδ T-cell receptor (TCR) repertoires of groups 1 and 2. In the absence of EBV, group 1 TCRγ chains are enriched for complementarity determining region 3 (CDR3s) containing JγP, whereas group 2 TCRγ chains are enriched for CDR3s containing Jγ2. In group 1 donors, EBV activates many γδ T cells expressing Vγ9JγP, inducing proliferation that produces a large population of activated effector cells. The TCRs using Vγ9JγP are closely related to the TCRs of γδ T cells that respond to phosphoantigens. In group 2 donors, EBV activates a small subpopulation of γδ T cells, most expressing Vγ9JγP. In conclusion, we find that differences in the TCRγ-chain repertoire underlie the differential response of group 1 and group 2 to EBV.

Sign in / Sign up

Export Citation Format

Share Document