Establishment and Characterization of a Murine Mast Cell Line Derived from NC/Nga Mice

2001 ◽  
Vol 125 (1) ◽  
pp. 67-70
Author(s):  
Kayako Hira ◽  
Kouichi Mitsuishi ◽  
Keiko Kawamoto ◽  
Hajime Suto ◽  
Atsuhito Nakao ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Line ◽  
Murine Mast Cell ◽  
Mast Cell Line

Phenotypic Characterization of the Human Mast-Cell Line HMC-1

1994 ◽  
Vol 39 (5) ◽  
pp. 489-498 ◽  
Author(s):  
G. NILSSON ◽  
T. BLOM ◽  
M. KUSCHE-GULLBERG ◽  
L. KJELLEN ◽  
J. H. BUTTERFIELD ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Line ◽  
Human Mast Cell ◽  
Phenotypic Characterization ◽  
Mast Cell Line

scholarly journals Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcεRI

2011 ◽  
Vol 127 (3) ◽  
pp. 815-822.e5 ◽  
Author(s):  
Tanya M. Laidlaw ◽  
John W. Steinke ◽  
Adrienne M. Tiñana ◽  
Chunli Feng ◽  
Wei Xing ◽  
...  
Keyword(s):  
Mast Cell ◽  
Stem Cell ◽  
Cell Line ◽  
Stem Cell Factor ◽  
Human Mast Cell ◽  
Mast Cell Line

Signaling pathways activated in a unique mast cell line where interleukin-3 supports survival and stem cell factor is required for a proliferative response

Blood ◽  
1996 ◽  
Vol 87 (9) ◽  
pp. 3655-3668 ◽  
Author(s):  
AM O'Farrell ◽  
M Ichihara ◽  
AL Mui ◽  
A Miyajima
Keyword(s):  
Mast Cell ◽  
Stem Cell ◽  
Mast Cells ◽  
Cell Line ◽  
Stem Cell Factor ◽  
Mapk Pathway ◽  
Interleukin 3 ◽  
Murine Mast Cell ◽  
Mast Cell Line

Stem cell factor (SCF) and interleukin-3 (IL-3) both act on several target hematopoietic populations, including mast cells. We have isolated a unique murine mast cell line, B6M, that is phenotypically similar to immature mast cells. For B6M cells, IL-3 is a survival factor and alone does not stimulate proliferation. SCF can stimulate proliferation of B6M cells, and together IL-3 and SCF synergize to stimulate optimal proliferation and long-term growth. A sustained induction of c-myc is observed only in the presence of SCF (with or without IL-3). In B6M cells, both IL-3 and SCF stimulate phosphorylation of Shc and activation of the Ras, Raf-1, MAPK pathway. Interestingly, IL-3 plus SCF synergistically activate MAPK. IL-3, but not SCF, leads to activation of Jak 2 and Stat 5 and induces pim-1 expression. From these data, we suggest that the induction of pim-1 and c-myc is independently regulated. Furthermore, IL-3-stimulated activation of the Jak 2/Stat 5 pathway, induction of pim-1, and activation of the Ras/MAPK pathway are insufficient to mediate proliferation of B6M cells. The unusual IL-3 response of B6M cells provides a useful model to dissect signals required for IL-3-stimulated survival and proliferation.

scholarly journals Interleukin-4-Mediated Suppression of Histamine Synthesis in a Murine Mast Cell Line, BNu-2cl3

2009 ◽  
Vol 32 (10) ◽  
pp. 1800-1802
Author(s):  
Norio Sato ◽  
Satoshi Tanaka ◽  
Junji Matsuura ◽  
Yuhji Takasu ◽  
Atsushi Ichikawa
Keyword(s):  
Mast Cell ◽  
Cell Line ◽  
Interleukin 4 ◽  
Histamine Synthesis ◽  
Murine Mast Cell ◽  
Mast Cell Line

scholarly journals Generation and characterization of novel canine malignant mast cell line CL1

2009 ◽  
Vol 127 (1-2) ◽  
pp. 114-124 ◽  
Author(s):  
Tzu-Yin Lin ◽  
Rachael Thomas ◽  
Pei-Chien Tsai ◽  
Matthew Breen ◽  
Cheryl A. London
Keyword(s):  
Mast Cell ◽  
Cell Line ◽  
Mast Cell Line

524 Single ion channels measured in a transformed murine mast cell line

1988 ◽  
Vol 81 (1) ◽  
pp. 299
Author(s):  
L.P. McKean ◽  
T.F. Smith ◽  
Y. Marunaka ◽  
D.C. Eaton
Keyword(s):  
Mast Cell ◽  
Ion Channels ◽  
Cell Line ◽  
Murine Mast Cell ◽  
Mast Cell Line

scholarly journals Characterization of a mast cell line that lacks the extracellular domain of membrane c‐kit

Immunology ◽  
1997 ◽  
Vol 90 (4) ◽  
pp. 518-525 ◽  
Author(s):  
Y. A. MEKORI ◽  
C. K. OH ◽  
J. DASTYCH ◽  
J. P. GOFF ◽  
S. ADACHI ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Line ◽  
Extracellular Domain ◽  
Mast Cell Line
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