Suppressive Effect of Topically Applied CX-659S, a Novel Diaminouracil Derivative, on the Contact Hypersensitivity Reaction in Various Animal Models

2000 ◽  
Vol 123 (4) ◽  
pp. 341-348 ◽  
Author(s):  
Yuso Goto ◽  
Yoshifumi Inoue ◽  
Masami Tsuchiya ◽  
Masakazu Isobe ◽  
Takamasa Ueno ◽  
...  
Keyword(s):  
Animal Models ◽  
Hypersensitivity Reaction ◽  
Suppressive Effect ◽  
Contact Hypersensitivity

Inhibitory Activities of Novel Pyrimidine Derivatives on the Contact Hypersensitivity Reaction.

ChemInform ◽  
2003 ◽  
Vol 34 (33) ◽  
Author(s):  
Yoshiaki Isobe ◽  
Masanori Tobe ◽  
Yoshifumi Inoue ◽  
Yuso Goto ◽  
Fumihiro Obara ◽  
...  
Keyword(s):  
Hypersensitivity Reaction ◽  
Contact Hypersensitivity ◽  
Pyrimidine Derivatives ◽  
Inhibitory Activities

scholarly journals Itraconazole Suppresses an Elicitation Phase of a Contact Hypersensitivity Reaction

2006 ◽  
Vol 126 (5) ◽  
pp. 1028-1035 ◽  
Author(s):  
Urupongsa Ausaneya ◽  
Akira Kawada ◽  
Yoshinori Aragane
Keyword(s):  
Hypersensitivity Reaction ◽  
Contact Hypersensitivity

Modification of LC Phenotype and Suppression of Contact Hypersensitivity Response by Stress

1998 ◽  
Vol 3 (2) ◽  
pp. 79-84 ◽  
Author(s):  
Junichi Hosoi ◽  
Toru Tsuchiya ◽  
Mitsuhiro Denda ◽  
Yutaka Ashida ◽  
Akira Takashima ◽  
...  
Keyword(s):  
Immune System ◽  
Hypersensitivity Reaction ◽  
Laser Scanning ◽  
Immobilization Stress ◽  
Confocal Laser Scanning Microscope ◽  
Contact Hypersensitivity ◽  
Confocal Laser ◽  
Scanning Microscope ◽  
Histocompatibility Complex ◽  
Epidermal Langerhans Cells

Background: Stress is thought to exacerbate a number of diseases, some of which are skin disorders. Epidermal Langerhans' cells play a major role in cutaneous immune reactions. Objective: The effects of two types of stress on the cutaneous immune system were to be assessed in mice. Methods: Mice received stress by immobilization or housing at various population densities. Epidermal sheets were stained for I-A molecules (a member of class II major histocompatibility complex) and analyzed with a confocal-laser-scanning microscope. Contact hypersensitivity reaction to 2,4,6-trinitrochlorobenzene was elicited in mouse ears. Results: The cell density, intensity of I-A expression, and number of dendrites were decreased as the population density increased. Elicitation of contact hypersensitivity was suppressed in mice that received either population or immobilization stress. Increased I-A expression and number of dendrites were observed in adrenalectomized compared to sham-operated mice. The population-dependent suppression of contact hypersensitivity reaction was not observed in adrenalectomized mice. After incubation with serum from mice that received either immobilization stress or population stress, the expression of I-A molecules on a XS52 Langerhans' cell-like cell line was reduced. Conclusion: Stress affected the cutaneous immune system. There were indications that adrenergic hormones played a role in the regulation of the system.

scholarly journals Diet-induced obesity aggravates NK cell-mediated contact hypersensitivity reaction in Rag1-/- mice

2020 ◽  
Author(s):  
Paulina Kowalczyk ◽  
Monika Majewska Szczepanik ◽  
Anna Strz pa ◽  
Dominika Bia a ◽  
Marian Szczepanik
Keyword(s):  
Hypersensitivity Reaction ◽  
Nk Cell ◽  
Contact Hypersensitivity ◽  
Diet Induced Obesity ◽  
Mediated Contact

Crosstalk between contact hypersensitivity reaction and antidepressant drugs

2013 ◽  
Vol 65 (6) ◽  
pp. 1673-1680 ◽  
Author(s):  
Katarzyna Curzytek ◽  
Marta Kubera ◽  
Marian Szczepanik ◽  
Agnieszka Basta-Kaim ◽  
Monika Leśkiewicz ◽  
...  
Keyword(s):  
Hypersensitivity Reaction ◽  
Antidepressant Drugs ◽  
Contact Hypersensitivity

scholarly journals Inhibitory Activities of Novel Pyrimidine Derivatives on the Contact Hypersensitivity Reaction

2003 ◽  
Vol 51 (3) ◽  
pp. 309-312 ◽  
Author(s):  
Yoshiaki Isobe ◽  
Masanori Tobe ◽  
Yoshifumi Inoue ◽  
Yuso Goto ◽  
Fumihiro Obara ◽  
...  
Keyword(s):  
Hypersensitivity Reaction ◽  
Contact Hypersensitivity ◽  
Pyrimidine Derivatives ◽  
Inhibitory Activities
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