Haplotype Analysis of BRCA2 8765delAG Mutation Carriers in French Canadian and Yemenite Jewish Hereditary Breast Cancer Families

2001 ◽  
Vol 52 (2) ◽  
pp. 116-120 ◽  
Author(s):  
Andrew P. Manning ◽  
Dvorah Abelovich ◽  
Parviz Ghadirian ◽  
Julie A. Lambert ◽  
Danielle Frappier ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hereditary Breast Cancer ◽  
Haplotype Analysis ◽  
French Canadian ◽  
Mutation Carriers

scholarly journals Prophylactic Mastectomy in BRCA1/2 Mutation Carriers and Women at Risk of Hereditary Breast Cancer: Long-Term Experiences at the Rotterdam Family Cancer Clinic

2007 ◽  
Vol 14 (12) ◽  
pp. 3335-3344 ◽  
Author(s):  
Bernadette A. M. Heemskerk-Gerritsen ◽  
Cecile T. M. Brekelmans ◽  
Marian B. E. Menke-Pluymers ◽  
Albert N. van Geel ◽  
Madeleine M. A. Tilanus-Linthorst ◽  
...  
Keyword(s):  
Breast Cancer ◽  
At Risk ◽  
Hereditary Breast Cancer ◽  
Prophylactic Mastectomy ◽  
Mutation Carriers ◽  
Cancer Clinic

scholarly journals Genetic sequence variations and ADPRT haplotype analysis in French Canadian families with high risk of breast cancer

2007 ◽  
Vol 52 (12) ◽  
pp. 963-977 ◽  
Author(s):  
Francine Durocher ◽  
◽  
Yvan Labrie ◽  
Geneviève Ouellette ◽  
Jacques Simard
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Haplotype Analysis ◽  
French Canadian ◽  
Genetic Sequence ◽  
Sequence Variations

Comparison of Breast Magnetic Resonance Imaging, Mammography, and Ultrasound for Surveillance of Women at High Risk for Hereditary Breast Cancer

2001 ◽  
Vol 19 (15) ◽  
pp. 3524-3531 ◽  
Author(s):  
E. Warner ◽  
D. B. Plewes ◽  
R. S. Shumak ◽  
G. C. Catzavelos ◽  
L. S. Di Prospero ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Hereditary Breast Cancer ◽  
Breast Magnetic Resonance Imaging ◽  
Clinical Breast Examination ◽  
Breast Cancers ◽  
Mutation Carriers ◽  
Breast Examination ◽  
Clinical Breast ◽  
Breast Magnetic Resonance

PURPOSE: Recommended surveillance for BRCA1 and BRCA2 mutation carriers includes regular mammography and clinical breast examination, although the effectiveness of these screening techniques in mutation carriers has not been established. The purpose of the present study was to compare breast magnetic resonance imaging (MRI) with ultrasound, mammography, and physical examination in women at high risk for hereditary breast cancer. PATIENTS AND METHODS: A total of 196 women, aged 26 to 59 years, with proven BRCA1 or BRCA2 mutations or strong family histories of breast or ovarian cancer underwent mammography, ultrasound, MRI, and clinical breast examination on a single day. A biopsy was performed when any of the four investigations was judged to be suspicious for malignancy. RESULTS: Six invasive breast cancers and one noninvasive breast cancer were detected among the 196 high-risk women. Five of the invasive cancers occurred in mutation carriers, and the sixth occurred in a woman with a previous history of breast cancer. The prevalence of invasive or noninvasive breast cancer in the 96 mutation carriers was 6.2%. All six invasive cancers were detected by MRI, all were 1.0 cm or less in diameter, and all were node-negative. In contrast, only three invasive cancers were detected by ultrasound, two by mammography, and two by physical examination. The addition of MRI to the more commonly available triad of mammography, ultrasound, and breast examination identified two additional invasive breast cancers that would otherwise have been missed. CONCLUSION: Breast MRI may be superior to mammography and ultrasound for the screening of women at high risk for hereditary breast cancer.

scholarly journals Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent

BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Luca Cavallone ◽  
Suzanna L Arcand ◽  
Christine Maugard ◽  
Parviz Ghadirian ◽  
Anne-Marie Mes-Masson ◽  
...  
Keyword(s):  
Haplotype Analysis ◽  
Brca2 Mutation ◽  
French Canadian ◽  
Brca1 And Brca2 ◽  
Mutation Carriers

scholarly journals Double PALB2 and BRCA1/BRCA2 mutation carriers are rare in breast cancer and breast-ovarian cancer syndrome families from the French Canadian founder population

2015 ◽  
Vol 9 (6) ◽  
pp. 2787-2790 ◽  
Author(s):  
FRÉDÉRIC ANCOT ◽  
SUZANNA L. ARCAND ◽  
ANNE-MARIE MES-MASSON ◽  
DIANE M. PROVENCHER ◽  
PATRICIA N. TONIN
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Brca2 Mutation ◽  
Founder Population ◽  
French Canadian ◽  
Cancer Syndrome ◽  
Mutation Carriers ◽  
Brca1 Brca2

Truncating variants in DNA-repair genes and their effect on AAO of hereditary breast cancer

2018 ◽  
Author(s):  
I Sepahi ◽  
U Faust ◽  
M Sturm ◽  
K Bosse ◽  
M Kehrer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Hereditary Breast Cancer ◽  
Dna Repair Genes ◽  
Repair Genes
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