Cytokine Levels and Phagocytic Activity in Patients with Alzheimer’s Disease

Gerontology ◽  
2002 ◽  
Vol 48 (3) ◽  
pp. 128-132 ◽  
Author(s):  
Yichayaou Beloosesky ◽  
Hertzel Salman ◽  
Michael Bergman ◽  
Hanna Bessler ◽  
Meir Djaldetti
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Phagocytic Activity ◽  
Cytokine Levels

scholarly journals Oral Infections and Cytokine Levels in Patients with Alzheimer’s Disease and Mild Cognitive Impairment Compared with Controls

2016 ◽  
Vol 54 (2) ◽  
pp. 845-845 ◽  
Author(s):  
José Augusto Ferrari Cestari ◽  
Gisele Maria Campos Fabri ◽  
Jorge Kalil ◽  
Ricardo Nitrini ◽  
Wilson Jacob-Filho ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Oral Infections ◽  
Cytokine Levels

Influence of plasma cytokine levels on the conversion risk from MCI to dementia in the Alzheimer's disease neuroimaging initiative database

2020 ◽  
Vol 414 ◽  
pp. 116829
Author(s):  
Kie Abe ◽  
Yuhei Chiba ◽  
Saki Hattori ◽  
Akihide Tamazawa ◽  
Asuka Yoshimi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Plasma Cytokine ◽  
Cytokine Levels

Oral Infections and Cytokine Levels in Patients with Alzheimer’s Disease and Mild Cognitive Impairment Compared with Controls

2016 ◽  
Vol 52 (4) ◽  
pp. 1479-1485 ◽  
Author(s):  
José Augusto Ferrari Cestari ◽  
Gisele Maria Campos Fabri ◽  
Jorge Kalil ◽  
Ricardo Nitrini ◽  
Wilson Jacob-Filho ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Oral Infections ◽  
Cytokine Levels

scholarly journals Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

2014 ◽  
Vol 50 (2) ◽  
pp. 534-544 ◽  
Author(s):  
Frederic Brosseron ◽  
Marius Krauthausen ◽  
Markus Kummer ◽  
Michael T. Heneka
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Body Fluid ◽  
Cytokine Levels

Increased serum levels of dehydroepiandrosterone (DHEA) and interleukin-6 (IL-6) in women with mild to moderate Alzheimer's disease

2011 ◽  
Vol 23 (9) ◽  
pp. 1386-1392 ◽  
Author(s):  
Sigbritt Rasmuson ◽  
Birgitta Näsman ◽  
Tommy Olsson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Interleukin 6 ◽  
Neuronal Excitability ◽  
Elderly Women ◽  
Serum Levels ◽  
Necrosis Factor Alpha ◽  
Healthy Elderly ◽  
Cytokine Levels ◽  
The Central Nervous System

ABSTRACTBackground: It has been suggested that hypercortisolism contributes to the pathophysiology of Alzheimer's disease (AD), based on the fact that excess glucocorticoid exposure has potent adverse effects on the central nervous system. In contrast, dehydroepiandrosterone (DHEA) has been linked to a broad range of beneficial physiological effects including neuronal excitability and neuroprotection and even memory enhancing properties. Of note, proinflammatory cytokines are present in neuritic plaques (a hallmark of AD) and may regulate cortisol/DHEA release. In this exploratory study, we hypothesized that there is a flattened diurnal curve of cortisol and DHEA in mild to moderate AD, linked to increased cytokine levels.Methods: Diurnal profiles of cortisol, adrenocorticotropic hormone (ACTH), and DHEA were studied in 15 patients with mild to moderate AD (7 men and 8 women, 75.6 ± 5.5 years) and 15 healthy elderly controls (7 men and 8 women, 73.3 ± 5.8 years, respectively). Interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and soluble TNF receptors were analyzed.Results: Women with AD had significantly increased morning levels of ACTH, DHEA, and IL-6 compared to healthy elderly women. Cortisol levels were significantly increased in men with AD at 0300 h versus healthy elderly men, in spite of slightly decreased ACTH levels.Conclusions: Our data suggest important sex differences in hypothalamic–pituitary–adrenal (HPA) axis regulation and steroid hormone clearance in patients with AD. Increased secretion of IL-6 may have a contributory role in this difference.

scholarly journals Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer’s disease

Brain ◽  
2021 ◽  
Author(s):  
Daniel Asby ◽  
Delphine Boche ◽  
Stuart Allan ◽  
Seth Love ◽  
J Scott Miners
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Factor ◽  
Vascular Function ◽  
Temporal Cortex ◽  
Systemic Infection ◽  
Cerebral Hypoperfusion ◽  
Cerebrovascular Function ◽  
Tnf Α ◽  
Cytokine Levels

Abstract We studied the effects of systemic infection on brain cytokine level and cerebral vascular function in Alzheimer’s disease (AD) and vascular dementia (VaD), in superior temporal cortex (BA22) from AD (n = 75), VaD (n = 22) and age-matched controls (n = 46), stratified according to the presence or absence of terminal systemic infection. Brain cytokine levels were measured using Mesoscale Discovery Multiplex Assays and markers of cerebrovascular function were assessed by ELISA. Multiple brain cytokines were elevated in AD and VaD: Interleukin (IL)-15 and IL-17A were maximally elevated in end-stage Alzheimer’s disease (Braak tangle stage V-VI) whereas IL-2, IL-5, IL12p40 and IL-16 were highest in intermediate Braak tangle stage III-IV disease. Several cytokines (IL-1β, IL-6, TNF-α, IL-8 and IL-15) were further raised in AD with systemic infection. Cerebral hypoperfusion, indicated by decreased myelin-associated glycoprotein: Proteolipid protein-1 (MAG: PLP1) and increased vascular endothelial growth factor-A (VEGF), and blood-brain barrier leakiness, indicated by raised levels of fibrinogen, were exacerbated in AD and VaD, and also in non-dementia controls, with systemic infection. Aβ42 level did not vary with infection or in association with brain cytokine levels. In controls, cortical perfusion declined with increasing interferon-γ (IFN-γ), IL-2, IL-4, IL-6, IL-10, IL-12p70, IL-13 and tumour necrosis factor-α (TNF-α) but these relationships were lost with progression of AD, and with infection (even in BS 0-II brains). Cortical platelet-derived growth factor receptor-β (PDGFRβ), a pericyte marker, was reduced, and endothelin-1 (EDN1) level was increased in AD; these were related to Aβ level and disease progression and only modestly affected by systemic infection. Our findings indicate that systemic infection alters brain cytokine levels and exacerbates cerebral hypoperfusion and BBB leakiness associated with AD and VaD, independently of the level of insoluble Aβ. Our findings highlight systemic infection as an important contributor to dementia, requiring early identification and treatment in the elderly population.

scholarly journals NEUTROPHILS’ FUNCTIONAL STATE IN ALZHEIMER’S DISEASE

2019 ◽  
Vol 19 (1S) ◽  
pp. 81-82
Author(s):  
P A Ivanov ◽  
A A Shmakova ◽  
N M Mikhailova
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional State ◽  
Phagocytic Activity ◽  
Control Group ◽  
Amino Acid Residues ◽  
Activity Increase ◽  
Microglial Phagocytosis ◽  
Key Factor ◽  
Peripheral Markers

Alzheimer’s disease (AD) is the most widespread neurodegenerative disease of older age, which is associated with the deposition of amyloid-beta polymerized peptide (consisting of 42 amino-acid residues) in the brain. The microglial phagocytosis disturbance, which is observed during AD, is possibly the key factor in the process. The research of neutrophils in patients with AD is of special interest due to the pressing problem of finding peripheral markers of AD. Analysis of neutrophils’ functional state in patients with AD is the objective of the present study. A reliable decrease of neutrophils’ phagocytic activity was established in group of patients with AD in comparison with control group (p < 0,05) (PI = 1.16 [0.64; 2.68] and PI = 2.34 [2.06; 2.85], respectively). A reliable increase of leukocytic elastase (LE) enzymatic activity (p < 0.05) was discovered in neutrophil lysate in AD group compared to control (LE = 0.43 [0.29; 0.77] and 0.29 [0.26; 0.38], respectively) at the same time. Comparison of PI and LE indicators in neutrophils’ lysate of AD group showed negative correlation between these parameters (r = 0.49, p < 0.05), which means that phagocytosis reduction during AD is accompanied by simultaneous LE activity increase in lysate of these cells.The obtained results allow to draw a conclusion that neutrophils’ phagocytic activity decreases during AD. Thus, discovered changes in neutrophils’ functional state can be considered as a potential peripheral AD marker.

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