Hypermetabolism of the Medial Temporal Lobe in Limbic Encephalitis on 18FDG-PET Scan: A Case Report

2001 ◽  
Vol 45 (3) ◽  
pp. 187-189 ◽  
Author(s):  
Duk L. Na ◽  
Dong Seok Hahm ◽  
Jung Mi Park ◽  
Sang Eun Kim
Keyword(s):  
Case Report ◽  
Temporal Lobe ◽  
Fdg Pet ◽  
Medial Temporal Lobe ◽  
Limbic Encephalitis ◽  
Pet Scan ◽  
Fdg Pet Scan

scholarly journals An evidence-based algorithm for the utility of FDG-PET for diagnosing Alzheimer's disease according to presence of medial temporal lobe atrophy

2016 ◽  
Vol 208 (5) ◽  
pp. 491-496 ◽  
Author(s):  
Michael J. Firbank ◽  
Jim Lloyd ◽  
David Williams ◽  
Robert Barber ◽  
Sean J. Colloby ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Temporal Lobe ◽  
Fdg Pet ◽  
Medial Temporal Lobe ◽  
Diagnostic Information ◽  
Pet Scan ◽  
Medial Temporal Lobe Atrophy ◽  
Fdg Pet Scan ◽  
Lobe Atrophy

BackgroundImaging biomarkers for Alzheimer's disease include medial temporal lobe atrophy (MTLA) depicted on computed tomography (CT) or magnetic resonance imaging (MRI) and patterns of reduced metabolism on fluorodeoxyglucose positron emission tomography (FDG-PET).AimsTo investigate whether MTLA on head CT predicts the diagnostic usefulness of an additional FDG-PET scan.MethodParticipants had a clinical diagnosis of Alzheimer's disease (n = 37) or dementia with Lewy bodies (DLB; n = 30) or were similarly aged controls (n = 30). We visually rated MTLA on coronally reconstructed CT scans and, separately and blind to CT ratings, abnormal appearances on FDG-PET scans.ResultsUsing a pre-defined cut-off of MTLA ⩾5 on the Scheltens (0–8) scale, 0/30 controls, 6/30 DLB and 23/30 Alzheimer's disease had marked MTLA. FDG-PET performed well for diagnosing Alzheimer's disease v. DLB in the low-MTLA group (sensitivity/specificity of 71%/79%), but in the high-MTLA group diagnostic performance of FDG-PET was not better than chance.ConclusionsIn the presence of a high degree of MTLA, the most likely diagnosis is Alzheimer's disease, and an FDG-PET scan will probably not provide significant diagnostic information. However, in cases without MTLA, if the diagnosis is unclear, an FDG-PET scan may provide additional clinically useful diagnostic information.

scholarly journals LGI1 positive paraneoplastic limbic encephalitis: A case report of atypical presentation

2021 ◽  
Vol 26 (4) ◽  
pp. 865-867
Author(s):  
Chien-Chung Cheng ◽  
Jia-Ying Sung ◽  
Chih-Shan Huang
Keyword(s):  
Case Report ◽  
Temporal Lobe ◽  
Rectal Carcinoma ◽  
Medial Temporal Lobe ◽  
Limbic Encephalitis ◽  
Memory Loss ◽  
Atypical Presentation ◽  
Paraneoplastic Limbic Encephalitis ◽  
Sensory Aphasia ◽  
Atypical Presentations

Limbic encephalitis is a rare disorder mainly affecting the medial temporal lobe and is classically paraneoplastic. Autoimmune etiologies also exist, such as antibodies against leucine-rich glioma activated 1 (LGI1). Most cases of anti-LGI1 encephalitis are not associated with tumors. Subacute memory loss is the predominant feature, and most patients develop focal seizures, especially faciobrachial dystonic seizures (FBDSs). Immunotherapies usually show a good response, but are less effective in paraneoplastic cases. We report a case of steroid-responsive anti-LGI1 encephalitis with atypical presentations of sensory aphasia during relapse from rectal carcinoma, an atypical site.

scholarly journals Primary Seminoma Localized in Mediastinum: Case Report

2019 ◽  
Vol 7 (3) ◽  
pp. 384-387
Author(s):  
Deva Petrova ◽  
Slavica Kraleva ◽  
Lilijana Muratovska ◽  
Biljana Crcareva
Keyword(s):  
Case Report ◽  
Fdg Pet ◽  
Pet Scan ◽  
Histopathological Analysis ◽  
Tumour Mass ◽  
Residual Tumour ◽  
Term Survival ◽  
Fdg Pet Scan ◽  
Β Hcg ◽  
Mediastinal Seminoma

BACKGROUND: Primary mediastinal seminomas most commonly occur in young men, and they are localised in the anterior mediastinum. CASE PRESENTATION: The presented study is a case report of a 34-year-old man suffering from a mediastinal tumour in size of 19 cm, with pleural and pericardial effusion. The patient complains of cough, difficulty breathing, weight loss, and pronounced tiredness. CT of lungs and biopsy of the mediastinal change was performed. The histopathological analysis was in favour of a primary mediastinal seminoma. The patient initially had pronouncedly increased levels of LDH and β-hCG tumour marker. Pericardiocentesis was realised due to threatening tamponade of the heart, followed by 4 cycles of chemotherapy by BEP protocol. Following 2 cycles of chemotherapy, normalisation of LDH and β-HCG levels and significantly improved the clinical condition in the patient was found. Upon completion of 4 chemotherapy cycles by BEP protocol, the patient performed an FDG-PET scan with partial response and reduced dimension of a primary tumour in the mediastinum. Radiotherapy of residual tumour mass up to a total dose of 40Gy in 20 fractions was realised. Control FDG-PET scan had a finding of complete response to a tumour and absence of FDG uptake. The last follow-up examination was performed in October 2018, and the patient was disease-free for 54 months. CONCLUSION: Multimodality treatment approach of chemotherapy followed by radiation consolidation ensured long-term survival in primary advanced mediastinal seminoma.

scholarly journals Insulinoma: is it still a diagnosis of exclusion? A case report

2016 ◽  
Vol 4 (1) ◽  
pp. 440
Author(s):  
Vipan Kumar ◽  
Vikrant Sharma ◽  
Ankur Sharma ◽  
Amit Rattan
Keyword(s):  
Case Report ◽  
Peripheral Neuropathy ◽  
High Resolution ◽  
Fdg Pet ◽  
Pet Scan ◽  
Dual Phase ◽  
Intractable Seizures ◽  
Progressive Encephalopathy ◽  
Fdg Pet Scan ◽  
Neurological Features

Few cases of hypoglycaemic peripheral neuropathy due to insulinoma have been reported in literature. We are reporting a case of insulinoma manifesting with chronic progressive encephalopathy, intractable seizures, and neuropathy-a triad of neurological features in insulinoma. The diagnosis was delayed as the repeated investigations including dual phase CECT abdomen was normal. This case report highlights the importance of evaluation of patients for insulinoma with high resolution CECT abdomen and FDG PET scan. A keen suspicion and investigation with appropriate modality can prevent the irreversible neuroglycopenic damage, as reported in this case.

Primary cardiac lymphoma detected by 18F-FDG PET scan: A case report

2011 ◽  
Vol 18 (5) ◽  
pp. 974-977 ◽  
Author(s):  
Jussara Bianchi Castelli ◽  
Leonardo Alexandre ◽  
Guilherme Futuro ◽  
Maurício Scanavacca ◽  
José Soares Júnior
Keyword(s):  
Case Report ◽  
Fdg Pet ◽  
Pet Scan ◽  
Cardiac Lymphoma ◽  
Primary Cardiac Lymphoma ◽  
Fdg Pet Scan ◽  
18F Fdg
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