Malignant Glioma as a Secondary Malignant Neoplasm after Radiation Therapy for Craniopharyngioma. Report of a Case and Review of Reported Cases

2001 ◽  
Vol 24 (1) ◽  
pp. 66-72 ◽  
Author(s):  
M. Kranzinger ◽  
N. Jones ◽  
O. Rittinger ◽  
P. Pilz ◽  
W.P. Piotrowski ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Malignant Glioma ◽  
Malignant Neoplasm ◽  
Secondary Malignant Neoplasm

scholarly journals Nasal adenocarcinoma as a suspected secondary malignant neoplasm in a cat previously treated for nasal lymphoma

2020 ◽  
Vol 6 (1) ◽  
pp. 205511692090835
Author(s):  
Gabrielle F Callanan ◽  
Kaitlin M Curran ◽  
Cyril Parachini-Winter ◽  
Shay Bracha ◽  
Sean Spagnoli ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Radiation Treatment ◽  
Present Report ◽  
Clinical Signs ◽  
Malignant Neoplasm ◽  
Facial Swelling ◽  
Nasal Adenocarcinoma ◽  
Nasal Lymphoma ◽  
Secondary Malignant Neoplasm ◽  
Multiagent Chemotherapy

Case summary A case of nasal adenocarcinoma as a suspected secondary malignant neoplasm following definitive radiation therapy and multiagent chemotherapy for nasal lymphoma is described. An 11-year-old spayed female domestic shorthair cat was presented for a 3-week history of progressive facial swelling located over the nasal planum and extending to the medial canthus of the right eye. The cat was previously diagnosed with nasal lymphoma and treated with chemotherapy and definitive radiation 2.5 years prior. Although a definitive diagnosis could not be obtained via cytology, recurrent lymphoma was suspected based on the cat’s history and recurrent clinical signs. A lymphoma-directed chemotherapy protocol was attempted, but no clinical response was achieved. The cat was euthanased owing to progressive clinical signs and a diagnosis of nasal adenocarcinoma was made on necropsy examination. Both the original diagnosis of nasal lymphoma and the secondary diagnosis of nasal adenocarcinoma were confirmed with immunohistochemistry. Relevance and novel information Secondary malignant neoplasm following radiation therapy is infrequently reported in the veterinary literature. In the few reports that exist, most have described sarcoma development in the dog following radiation therapy. In the present report, we describe a cat with a suspected radiation-induced nasal adenocarcinoma that developed 2.5 years after definitive radiation treatment for nasal lymphoma.

BCNU-POLYMER AND CONCURRENT RADIATION THERAPY PROLONG SURVIVAL IN A MALIGNANT GLIOMA MODEL

1996 ◽  
Vol 89 (Supplement) ◽  
pp. S66-S67
Author(s):  
Matthew G. Ewend ◽  
Jeffery Williams ◽  
Betty Tyler ◽  
Richard Anderson ◽  
Khosrow Tabassi ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Malignant Glioma ◽  
Glioma Model

scholarly journals Intensive Multimodality Treatment for Children With Newly Diagnosed CNS Atypical Teratoid Rhabdoid Tumor

2009 ◽  
Vol 27 (3) ◽  
pp. 385-389 ◽  
Author(s):  
Susan N. Chi ◽  
Mary Ann Zimmerman ◽  
Xiaopan Yao ◽  
Kenneth J. Cohen ◽  
Peter Burger ◽  
...  
Keyword(s):  
Overall Survival ◽  
Radiation Therapy ◽  
Objective Response Rate ◽  
Response Rate ◽  
Objective Response ◽  
Malignant Neoplasm ◽  
Rhabdoid Tumor ◽  
Atypical Teratoid Rhabdoid Tumor ◽  
Newly Diagnosed ◽  
Atypical Teratoid

Purpose Atypical teratoid rhabdoid tumor (ATRT) of the CNS is a highly malignant neoplasm primarily affecting young children, with a historic median survival ranging from 6 to 11 months. Based on a previous pilot series, a prospective multi-institutional trial was conducted for patients with newly diagnosed CNS ATRT. Patients and Methods Treatment was divided into five phases: preirradiation, chemoradiation, consolidation, maintenance, and continuation therapy. Intrathecal chemotherapy was administered, alternating intralumbar and intraventricular routes. Radiation therapy (RT) was prescribed, either focal (54 Gy) or craniospinal (36 Gy, plus primary boost), depending on age and extent of disease at diagnosis. Results Between 2004 and 2006, 25 patients were enrolled; 20 were eligible for evaluation. Median age at diagnosis was 26 months (range, 2.4 months to 19.5 years). Gross total resection of the primary tumor was achieved in 11 patients. Fourteen patients had M0 disease at diagnosis, one patient had M2 disease, and five patients had M3 disease. Fifteen patients received radiation therapy: 11 focal and four craniospinal. Significant toxicities, in addition to the expected, included radiation recall (n = 2) and transverse myelitis (n = 1). There was one toxic death. Of the 12 patients who were assessable for chemotherapeutic response (pre-RT), the objective response rate was 58%. The objective response rate observed after RT was 38%. The 2-year progression-free and overall survival rates are 53% ± 13% and 70% ± 10%, respectively. Median overall survival has not yet been reached. Conclusion This intensive multimodality regimen has resulted in a significant improvement in time to progression and overall survival for patients with this previously poor-prognosis tumor.

scholarly journals Cerebellar Malignant Glioma after Radiation Therapy for Suprasellar Germinoma

1989 ◽  
Vol 29 (3) ◽  
pp. 223-229 ◽  
Author(s):  
Tohru TAMURA ◽  
Saburo NAKAMURA ◽  
Kanji SHIRATA ◽  
Kohten SATO ◽  
Takashi TSUBOKAWA ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Malignant Glioma ◽  
Suprasellar Germinoma

scholarly journals Potentiation of radiation therapy by the oncolytic adenovirus dl1520 (ONYX-015) in human malignant glioma xenografts

2003 ◽  
Vol 89 (3) ◽  
pp. 577-584 ◽  
Author(s):  
B Geoerger ◽  
J Grill ◽  
P Opolon ◽  
J Morizet ◽  
G Aubert ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Malignant Glioma ◽  
Oncolytic Adenovirus ◽  
Human Malignant Glioma
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