Role of the Fas System in Liver Regeneration after a Partial Hepatectomy in Rats

2001 ◽  
Vol 33 (5-6) ◽  
pp. 334-341 ◽  
Author(s):  
K. Taira ◽  
S. Hiroyasu ◽  
M. Shiraishi ◽  
Y. Muto ◽  
T. Koji
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy

531 THE ROLE OF PLACENTAL GROWTH FACTOR AND ITS RECEPTOR IN LIVER REGENERATION AFTER PARTIAL HEPATECTOMY

2008 ◽  
Vol 48 ◽  
pp. S199-S200
Author(s):  
E. Vanheule ◽  
Y.-D. Fan ◽  
J. Van Huysse ◽  
D. Meester ◽  
M. Praet ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Placental Growth Factor

scholarly journals Delayed liver regeneration in mice lacking liver serum response factor

2007 ◽  
Vol 292 (4) ◽  
pp. G996-G1001 ◽  
Author(s):  
M. Ujue Latasa ◽  
Dominique Couton ◽  
Claude Charvet ◽  
Aurélie Lafanechère ◽  
Jacques-Emmanuel Guidotti ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Serum Response Factor ◽  
Early Response ◽  
Mutant Mice ◽  
Response Factor ◽  
Impaired Liver ◽  
Serum Response

Various immediate early genes (IEGs) upregulated during the early process of liver regeneration are transcriptional targets of the serum response factor (SRF). We show here that the expression of SRF is rapidly induced in rodent liver after partial hepatectomy. Because the inactivation of the SRF gene in mice is embryonic lethal, the in vivo role of SRF in liver regeneration after partial hepatectomy was analyzed in mutant mice conditionally deleted for SRF in the liver. We demonstrate that SRF is not an essential factor for liver ontogenesis. However, adult mutant mice show impaired liver regeneration after partial hepatectomy, associated with a blunted upregulation of various SRF target IEGs. In conclusion, our work suggests that SRF is an early response transcription factor that may contribute to the initial phases of liver regeneration through its activation of IEGs.

Role of heparin-binding epidermal growth factor–like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy

Hepatology ◽  
1995 ◽  
Vol 22 (5) ◽  
pp. 1584-1590 ◽  
Author(s):  
Shinichi Kiso ◽  
Sumio Kawata ◽  
Shinji Tamura ◽  
Shigeki Higashiyama ◽  
Nobuyuki Ito ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Heparin Binding ◽  
Rat Liver Regeneration ◽  
Epidermal Growth

The Role of TWEAK/Fn14 Signaling in Liver Regeneration after Mouse Partial Hepatectomy

2012 ◽  
Vol 94 (10S) ◽  
pp. 654
Author(s):  
S. R. Cader ◽  
T. Kawahara ◽  
C. H. Pu ◽  
J. T. Lewis ◽  
T. A. Churchill ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy

SUN-P071: The Role of Glucose, Insulin, and Glucagon During Liver Regeneration After Partial Hepatectomy

2017 ◽  
Vol 36 ◽  
pp. S79-S80
Author(s):  
H.-S. Lai ◽  
S.-L. Lai ◽  
S.-C. Wu ◽  
W.-J. Chen
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy

scholarly journals IL-22 is involved in liver regeneration after hepatectomy

2010 ◽  
Vol 298 (1) ◽  
pp. G74-G80 ◽  
Author(s):  
Xiaodan Ren ◽  
Bin Hu ◽  
Lisa M. Colletti
Keyword(s):  
Liver Regeneration ◽  
General Anesthesia ◽  
Partial Hepatectomy ◽  
Potential Role ◽  
Cellular Proliferation ◽  
Cell Types ◽  
In Vitro Studies ◽  
Hepatocyte Proliferation

Hepatocyte proliferation following partial hepatectomy is an important component of liver regeneration, and recent in vitro studies have shown that IL-22 is involved in cellular proliferation in a variety of cell types, including hepatocytes. IL-22 functions through IL-10Rβ and IL-22Rα. The goal of this study was to investigate the potential role of IL-22 in liver regeneration after 70% hepatectomy. Following 70% hepatectomy, done under general anesthesia in mice, serum IL-22 and hepatic IL-22Rα mRNA were significantly increased. Although administration of exogenous IL-22 prior to hepatectomy did not increase hepatocyte proliferation, administration of anti-IL-22 antibody before hepatectomy did significantly decrease hepatocyte proliferation. Furthermore, IL-22 treatment prior to 70% hepatectomy induced stat-3 activation; no significant changes were seen in ERK1/2 activation, stat-1 activation, or stat-5 activation. IL-22 pretreatment also significantly increased hepatic and serum IL-6 levels. In addition, animals treated with anti-IL-22 antibody also expressed less TGF-α. In conclusion, these data suggest that IL-22 is involved in liver regeneration and this may be due to interaction with IL-6 and TGF-α cascades.

Role of the hepatic branch of the vagus nerve in liver regeneration in rats

1987 ◽  
Vol 253 (4) ◽  
pp. G439-G444 ◽  
Author(s):  
K. Tanaka ◽  
S. Ohkawa ◽  
T. Nishino ◽  
A. Niijima ◽  
S. Inoue
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Vagus Nerve ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Specific Effect ◽  
The Body ◽  
Subdiaphragmatic Vagotomy ◽  
Hepatic Branch

The role of the vagus nerve in liver regeneration after partial hepatectomy was examined by comparing the effects of hepatic vagotomy (sectioning of the hepatic branch of the vagus nerve) with those of subdiaphragmatic vagotomy in rats. Hepatic vagotomy delayed but did not suppress the increase in the rate of hepatic DNA synthesis and the activity of thymidine kinase after partial hepatectomy. On the other hand, subdiaphragmatic vagotomy delayed and suppressed these indices. The time courses of restoration of liver DNA content after partial hepatectomy were not affected by hepatic vagotomy. However, this index was both delayed and suppressed in subdiaphragmatic vagotomized rats. Hepatic vagotomy did not affect the daily food intake or the body weight increase after partial hepatectomy. However, subdiaphragmatic vagotomy caused considerably more loss of food intake and body weight. There were no differences in the plasma insulin levels after partial hepatectomy among three groups. We concluded that a vagal specific effect is evident in the delay but fails to suppress liver regeneration.

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