Greater Resistance and Lower Contribution of Free Radicals to Hypoxic Neurotoxicity in Immature Rat Brain Compared to Adult Brain as Revealed by Dynamic Changes in Glucose Metabolism

2001 ◽  
Vol 23 (6) ◽  
pp. 412-419 ◽  
Author(s):  
Nobuyuki Maruoka ◽  
Tetsuhito Murata ◽  
Naoto Omata ◽  
Yasuhisa Fujibayashi ◽  
Atsuo Waki ◽  
...  
Keyword(s):  
Free Radicals ◽  
Glucose Metabolism ◽  
Rat Brain ◽  
Adult Brain ◽  
Dynamic Changes ◽  
Immature Rat ◽  
Lower Contribution

Neurotoxicity after hypoxia/during ischemia due to glutamate with/without free radicals as revealed by dynamic changes in glucose metabolism

2000 ◽  
Vol 865 (2) ◽  
pp. 259-263 ◽  
Author(s):  
Tetsuhito Murata ◽  
Naoto Omata ◽  
Yasuhisa Fujibayashi ◽  
Atsuo Waki ◽  
Norihiro Sadato ◽  
...  
Keyword(s):  
Free Radicals ◽  
Glucose Metabolism ◽  
Dynamic Changes

Dynamic changes in glucose metabolism of living rat brain slices induced by hypoxia and neurotoxic chemical-loading revealed by positron autoradiography

1999 ◽  
Vol 106 (11-12) ◽  
pp. 1075-1087 ◽  
Author(s):  
T. Murata ◽  
N. Omata ◽  
Y. Fujibayashi ◽  
A. Waki ◽  
N. Sadato ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Rat Brain ◽  
Brain Slices ◽  
Dynamic Changes ◽  
Chemical Loading

scholarly journals Hypoxic but Not Ischemic Neurotoxicity of Free Radicals Revealed by Dynamic Changes in Glucose Metabolism of Fresh Rat Brain Slices on Positron Autoradiography

2000 ◽  
Vol 20 (2) ◽  
pp. 350-358 ◽  
Author(s):  
Naoto Omata ◽  
Tetsuhito Murata ◽  
Yasuhisa Fujibayashi ◽  
Atsuo Waki ◽  
Norihiro Sadato ◽  
...  
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Rat Brain ◽  
Neuroprotective Effect ◽  
Brain Slices ◽  
Nmda Antagonist ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Dynamic Changes ◽  
K Value

Dynamic changes in the regional cerebral glucose metabolic rate induced by hypoxia/reoxygenation or ischemia/reperfusion were investigated with a positron autoradiography technique. Fresh rat brain slices were incubated with [18F]2-fluoro-2-deoxy-D-glucose ([18F]FDG) in oxygenated Krebs-Ringer solution at 36°C, and serial two-dimensional time-resolved images of [18F]FDG uptake in the slices were obtained. In the case of loading hypoxia (oxygen deprivation)/pseudoischemia (oxygen and glucose deprivation) for various periods of time, the net influx constant ( K) of [18F]FDG at preloading and after reoxygenation/pseudoreperfusion (post-loading) was quantitatively evaluated by applying the Patlak graphical method to the image data. Regardless of the brain region, with hypoxia lasting ≥20 minutes, the postloading K value was decreased compared with the unloaded control, whereas with pseudoischemia of ≤40 minutes, approximately the same level as the unloaded control was maintained. Next, the neuroprotective effect against hypoxia/pseudoischemia loading induced by the addition of a free radical scavenger or an N-methyl-D-aspartate (NMDA) antagonist was assessed by determining whether a decrease in the postloading K value was prevented. Whereas with 20-minute hypoxia, both agents exhibited a neuroprotective effect, in the case of 50-minute pseudoischemia, only the NMDA antagonist did so, with the free radical scavenger being ineffective. These results demonstrate that hypoxia causes irreversible neuronal damage within a shorter period than ischemia, with both free radicals and glutamate suggested to be involved in tandem in the neurotoxicity induced by hypoxia, whereas glutamate alone is involved in ischemic neurotoxicity.

Hypoxic tolerance induction in rat brain slices following 3-nitropropionic acid pretreatment as revealed by dynamic changes in glucose metabolism

2002 ◽  
Vol 319 (2) ◽  
pp. 83-86 ◽  
Author(s):  
Nobuyuki Maruoka ◽  
Tetsuhito Murata ◽  
Naoto Omata ◽  
Yasuhisa Fujibayashi ◽  
Yoshiharu Yonekura ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Rat Brain ◽  
Brain Slices ◽  
Tolerance Induction ◽  
Acid Pretreatment ◽  
Dynamic Changes ◽  
Nitropropionic Acid ◽  
Hypoxic Tolerance ◽  
3 Nitropropionic Acid

Biphasic mechanism of the toxicity induced by 1-methyl-4-phenylpyridinium ion (MPP+) as revealed by dynamic changes in glucose metabolism in rat brain slices

2007 ◽  
Vol 28 (3) ◽  
pp. 672-678 ◽  
Author(s):  
Nobuyuki Maruoka ◽  
Tetsuhito Murata ◽  
Naoto Omata ◽  
Yasuhiro Takashima ◽  
Yasuhisa Fujibayashi ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Rat Brain ◽  
Brain Slices ◽  
Dynamic Changes

Distribution of and steroid hormone effects on calbindin-D9k in the immature rat brain

2019 ◽  
Author(s):  
Seon Mi Park ◽  
Seon Young Park ◽  
Dinh Nam Tran ◽  
Eui-Bae Jeung
Keyword(s):  
Rat Brain ◽  
Steroid Hormone ◽  
Immature Rat ◽  
Calbindin D9k ◽  
Hormone Effects

Pre- and postnatal lead exposure affects the serotonergic system in the immature rat brain

1991 ◽  
Vol 47 (5) ◽  
pp. 463-466 ◽  
Author(s):  
H. R. Widmer ◽  
E. E. Bütikofer ◽  
M. Schlumpf ◽  
W. Lichtensteiger
Keyword(s):  
Rat Brain ◽  
Lead Exposure ◽  
Serotonergic System ◽  
Immature Rat

Developmental profile of three enolase isozymes in rat brain determination from one-cell embryo to adult brain

1984 ◽  
Vol 6 (1) ◽  
pp. 51-54 ◽  
Author(s):  
K. Kato ◽  
F. Suzuki ◽  
T. Watanabe ◽  
R. Semba ◽  
H. Keino
Keyword(s):  
Rat Brain ◽  
Adult Brain ◽  
Developmental Profile ◽  
Cell Embryo
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