Association Analysis for the Genetic Variants of the NMDA Receptor Subunit 2b and Alzheimer’s Disease

2002 ◽  
Vol 13 (2) ◽  
pp. 91-94 ◽  
Author(s):  
Shih-Jen Tsai ◽  
Hsiu-Chih Liu ◽  
Tsung-Yun Liu ◽  
Chih-Ya Cheng ◽  
Chen-Jee Hong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nmda Receptor ◽  
Association Analysis ◽  
Genetic Variants ◽  
Receptor Subunit ◽  
Nmda Receptor Subunit

scholarly journals Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease

2008 ◽  
Vol 29 (10) ◽  
pp. 1524-1532 ◽  
Author(s):  
Shirley W.Y. Tsang ◽  
Harry V. Vinters ◽  
Jeffrey L. Cummings ◽  
Peter T.-H. Wong ◽  
Christopher P.L.-H. Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nmda Receptor ◽  
Ligand Binding ◽  
Receptor Subunit ◽  
Nmda Receptor Subunit ◽  
Recognition Sites ◽  
Chronic Anxiety

Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A

2021 ◽  
Author(s):  
Weiwei Zhong ◽  
Anika Wu ◽  
Ken Berglund ◽  
Xiaohuan Gu ◽  
Michael Qize Jiang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nmda Receptor ◽  
Receptor Subunit ◽  
Sporadic Alzheimer’S Disease ◽  
Nmda Receptor Subunit

Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer’s disease

2013 ◽  
Author(s):  
Virginia Andreoli ◽  
Elvira Valeria De Marco ◽  
Francesca Trecroci ◽  
Rita Cittadella ◽  
Gemma Di Palma ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nmda Receptor ◽  
Receptor Subunit ◽  
Nmda Receptor Subunit

Association analysis of polymorphisms in the N-methyl-d-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia

2007 ◽  
Vol 153 (3) ◽  
pp. 271-275 ◽  
Author(s):  
Ying-Jay Liou ◽  
Ying-Chieh Wang ◽  
Jen-Yeu Chen ◽  
Ya-Mei Bai ◽  
Chao-Cheng Lin ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Tardive Dyskinesia ◽  
Association Analysis ◽  
Receptor Subunit ◽  
Nmda Receptor Subunit

Electroacupuncture ameliorates CUMS-induced depression-like behavior: involvement of the glutamatergic system and apoptosis in rats

2020 ◽  
Vol 23 ◽  
Author(s):  
Qin Guo ◽  
Xian-Ming Lin ◽  
Zhong Di ◽  
Quan-Ai Zhang ◽  
Shuo Jiang
Keyword(s):  
Nmda Receptor ◽  
Caspase 3 ◽  
B Cell Lymphoma ◽  
Sucrose Preference ◽  
Expression Level ◽  
Receptor Subunit ◽  
Glutamatergic System ◽  
Ionotropic Receptor ◽  
Nmda Receptor Subunit ◽  
Expression Levels

Background: Converging evidence indicates that glutamatergic system and glia are directly implicated in the pathophysiology of depression. Clinical studies indicate that electroacupuncture (EA) has antidepressant-like effect with low side effects for depression. However, the underlying antidepressant mechanism of acupuncture remains obscure. Methods: Chronic unpredictable mild stress (CUMS)-induced depressive rats were used to induce depressive-like behavior, and evaluated by the weight change, open field test, sucrose preference test, and novelty suppressed feeding test. EA, NMDA receptor subunit 2A antagonist (NR2A RA) or NMDA receptor subunit 2B antagonist (NR2B RA) was used for comparison. High performance liquid chromatography (HPLC) was performed to detect the content of hippocampal glutamate, while western blot for the hippocampal protein expression levels of calcium/calmodulin-dependent protein kinase II (CaMKII), Bax, caspase 3 and B-cell lymphoma-2 (Bcl-2). The distribution of glutamate ionotropic receptor NMDA type subunit 2A (NR2A), neuronal nuclear protein (NeuN), glutamate ionotropic receptor NMDA type subunit 2B (NR2B) and glial fibrillary acidic protein (GFAP) were detected by immunofluorescence. Results: Significant depression behavior (reduced body weight and sucrose preference, increased feeding and immobility time) was produced in CUMS-induced depressive rats, which was reversed significantly by EA. EA decreased hippocampal glutamate level. EA led to a significant decrease in expression levels of Bax, caspase 3 and CaMKⅡ accompanied by increased Bcl-2 expression level. Furthermore, EA significantly increased NR2A expression level as well as decreased NR2B expression level in hippocampus. Conclusion: EA ameliorated depression-like behavior in CUMS rats, which might be mediated, at least in part, by regulating the glutamate, NMDA receptors and apoptosis in the hippocampus.

CCL8/MCP-2 association analysis in patients with Alzheimer’s disease and frontotemporal lobar degeneration

2009 ◽  
Vol 256 (8) ◽  
pp. 1379-1381 ◽  
Author(s):  
Chiara Villa ◽  
Eliana Venturelli ◽  
Chiara Fenoglio ◽  
Francesca Clerici ◽  
Alessandra Marcone ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Analysis ◽  
Frontotemporal Lobar Degeneration
Sign in / Sign up

Export Citation Format

Share Document