p53 Protein Accumulation in Multiple Oesophageal Squamous Cell Carcinoma: Relationship to Risk Factors

Oncology ◽  
2002 ◽  
Vol 62 (2) ◽  
pp. 175-179 ◽  
Author(s):  
Hiroshi Saeki ◽  
Shinji Ohno ◽  
Mitsuhiro Miyazaki ◽  
Koshi Araki ◽  
Akinori Egashira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P53 Protein ◽  
Protein Accumulation ◽  
Oesophageal Squamous Cell Carcinoma

scholarly journals MicroRNA Polymorphisms and Environmental Smoke Exposure as Risk Factors for Oesophageal Squamous Cell Carcinoma

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e78520 ◽  
Author(s):  
Yabing Wang ◽  
Matjaz Vogelsang ◽  
Georgia Schäfer ◽  
Marco Matejcic ◽  
M. Iqbal Parker
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Smoke Exposure ◽  
Oesophageal Squamous Cell Carcinoma

scholarly journals Gender Differences in Oesophageal Squamous Cell Carcinoma in a South African Tertiary Hospital

2020 ◽  
Vol 17 (19) ◽  
pp. 7086
Author(s):  
Lucien Ferndale ◽  
Colleen Aldous ◽  
Richard Hift ◽  
Sandie Thomson
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Risk Factor ◽  
Alcohol Consumption ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Presentation ◽  
Tertiary Hospital ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Males And Females

(1) Oesophageal squamous cell carcinoma is common in Africa and has a male preponderance. The gender-based differences in clinical presentation and risk factor exposure are poorly studied in the African context. Our aim was to compare males and females with this disease. We analyzed the differences in clinical features and risk factor exposure between males and females with oesophageal cancer. (2) Data from patients presenting to a tertiary hospital in South Africa with oesophageal squamous cell carcinoma were analyzed. Data collected included patient demographics, clinical presentation, pathology and risk factor exposure. (3) Three hundred and sixty three patients were included in the study. The male to female ratio was 1.4:1. The mean age was 66 years for females and 61 years for males (p < 0.0001). A significantly larger percentage of males were underweight compared to females (60% vs. 32%, p < 0.001). There were no differences between the genders with regards to performance status, dysphagia grade and duration and tumor length, location and degree of differentiation. There were significant differences between risk factor exposure between the two genders. Smoking and alcohol consumption was an association in more than 70% of males but in less than 10% of females There was no difference survival. (4) Female patients with oesophageal squamous cell carcinoma (OSCC) are older and have a higher body mass index (BMI) than their male counterparts. Traditionally purported risk factors of smoking and alcohol consumption are infrequent associations with OSCC in female patients and other environmental risk factors may be more relevant in this gender.

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