Anticarcinogenic Effects of Isoflavones May Be Mediated by Genistein in Mouse Mammary Tumor Virus-Induced Breast Cancer

Oncology ◽  
2002 ◽  
Vol 62 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Hirobumi Mizunuma ◽  
Kyotaro Kanazawa ◽  
Shigeto Ogura ◽  
Shin Otsuka ◽  
Hideo Nagai
Keyword(s):  
Breast Cancer ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

scholarly journals Heregulin Co-opts PR Transcriptional Action Via Stat3 Role As a Coregulator to Drive Cancer Growth

2015 ◽  
Vol 29 (10) ◽  
pp. 1468-1485 ◽  
Author(s):  
Cecilia J. Proietti ◽  
Franco Izzo ◽  
María Celeste Díaz Flaqué ◽  
Rosalía Cordo Russo ◽  
Leandro Venturutti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathways ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Cancer Growth ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Virus Promoter

Abstract Accumulated findings have demonstrated the presence of bidirectional interactions between progesterone receptor (PR) and the ErbB family of receptor tyrosine kinases signaling pathways in breast cancer. We previously revealed signal transducer and activator of transcription 3 (Stat3) as a nodal convergence point between said signaling pathways proving that Stat3 is activated by one of the ErbBs' ligands, heregulin (HRG)β1 via ErbB2 and through the co-option of PR as a signaling molecule. Here, we found that HRGβ1 induced Stat3 recruitment to the promoters of the progestin-regulated cell cycle modulators Bcl-XL and p21CIP1 and also stimulated Stat3 binding to the mouse mammary tumor virus promoter, which carries consensus progesterone response elements. Interestingly, HRGβ1-activated Stat3 displayed differential functions on PR activity depending on the promoter bound. Indeed, Stat3 was required for PR binding in bcl-X, p21CIP1, and c-myc promoters while exerting a PR coactivator function on the mouse mammary tumor virus promoter. Stat3 also proved to be necessary for HRGβ1-induced in vivo tumor growth. Our results endow Stat3 a novel function as a coregulator of HRGβ1-activated PR to promote breast cancer growth. These findings underscore the importance of understanding the complex interactions between PR and other regulatory factors, such as Stat3, that contribute to determine the context-dependent transcriptional actions of PR.

A Mouse Mammary Tumor Virus-Like Long Terminal Repeat Superantigen in Human Breast Cancer

2004 ◽  
Vol 64 (12) ◽  
pp. 4105-4111 ◽  
Author(s):  
Yue Wang ◽  
Jian-Dong Jiang ◽  
Dongping Xu ◽  
Yan Li ◽  
Chunfeng Qu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Long Terminal Repeat ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Human Breast Cancer ◽  
Terminal Repeat ◽  
Human Breast ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

scholarly journals No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with Breast Cancer in Mexican Women

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Abigail Morales-Sánchez ◽  
Tzindilú Molina-Muñoz ◽  
Juan L. E. Martínez-López ◽  
Paulina Hernández-Sancén ◽  
Alejandra Mantilla ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Epstein Barr Virus ◽  
Mexican Women ◽  
Mammary Tumor Virus ◽  
Barr Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Epstein Barr

Increased incidence of mouse mammary tumor virus-related antigen in tunisian patients with breast cancer

1984 ◽  
Vol 33 (3) ◽  
pp. 305-308 ◽  
Author(s):  
P. H. Levine ◽  
R. Mesa-Tejada ◽  
I. Keydar ◽  
F. Tabbane ◽  
S. Spiefelman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tunisian Patients ◽  
Tumor Virus

No association of mouse mammary tumor virus-related retrovirus with Japanese cases of breast cancer

2008 ◽  
Vol 80 (8) ◽  
pp. 1447-1451 ◽  
Author(s):  
Hidetoshi Fukuoka ◽  
Masako Moriuchi ◽  
Hiroshi Yano ◽  
Takeshi Nagayasu ◽  
Hiroyuki Moriuchi
Keyword(s):  
Breast Cancer ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

Antibodies reactive with the mouse mammary tumor virus in sera of breast cancer patients

1980 ◽  
Vol 25 (6) ◽  
pp. 721-725 ◽  
Author(s):  
Steven S. Witkin ◽  
Nurul H. Sarkar ◽  
David W. Kinne ◽  
Robert A. Good ◽  
Noorbibi K. Day
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Breast Cancer Patients ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus
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