Characterization of Interactions between Transcription Factors and a Regulatory Region Spanning nt –320 to –281 of the HIV-1 LTR in T-Lymphoid and Non-T-Lymphoid Cells

2002 ◽  
Vol 9 (1) ◽  
pp. 68-81
Author(s):  
Lloyd A. Pereira ◽  
Melissa J. Churchill ◽  
Andrew G. Elefanty ◽  
Theo Gouskos ◽  
Paul F. Lambert ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Regulatory Region ◽  
Lymphoid Cells ◽  
Hiv 1

Characterization of interactions between transcription factors and a regulatory region spanning nt −320 to −281 of the HIV-1 LTR in T-lymphoid and non-T-lymphoid cells

2002 ◽  
Vol 9 (1) ◽  
pp. 68-81
Author(s):  
Lloyd A. Pereira ◽  
Melissa J. Churchill ◽  
Andrew G. Elefanty ◽  
Theo Gouskos ◽  
Paul F. Lambert ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Regulatory Region ◽  
Lymphoid Cells ◽  
Hiv 1

scholarly journals The characterization of MCEF : an AFF transcription factor associated with acute lymphoglastic leukemia and HIV-1

2021 ◽  
Author(s):  
Zainab Al Shawaf
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Acute Lymphoblastic Leukemia ◽  
Virus Replication ◽  
Lymphoblastic Leukemia ◽  
Mixed Lineage Leukemia ◽  
Live Virus ◽  
Partner Gene ◽  
Hiv 1

Acute Lymphoblastic Leukemia (ALL) results from environmentally-triggered in utero translocations between the Mixed Lineage Leukemia (MLL) gene and partner genes. In the most frequent cases of ALL, this partner gene is one of the AF4 family (AFF) of transcription factors. The newest AFF member to be discovered and cloned is AFF-4/AF5q31/MCEF. MCEF interacts with a transcription factor necessary for transcription of HIV-1. In addition, evidence suggests that male knockout mice are azoospermic. Therefore, the characterization of MCEF is clinically and theoretically important. The purpose of my research was to further characterize MCEF. In this paper, I first review the AFF members, focusing on MCEF. I then show a series of experimental results addressing MCEF isoforms and HIV-1 repression domains, as well as the generation of anti-MCEF antisera. Finally, I highlight intriguing results with live virus replication assays that suggest how MCEF could be exploited as a therapeutic target for AIDS.

scholarly journals The characterization of MCEF : an AFF transcription factor associated with acute lymphoglastic leukemia and HIV-1

2021 ◽  
Author(s):  
Zainab Al Shawaf
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Acute Lymphoblastic Leukemia ◽  
Virus Replication ◽  
Lymphoblastic Leukemia ◽  
Mixed Lineage Leukemia ◽  
Live Virus ◽  
Partner Gene ◽  
Hiv 1

Acute Lymphoblastic Leukemia (ALL) results from environmentally-triggered in utero translocations between the Mixed Lineage Leukemia (MLL) gene and partner genes. In the most frequent cases of ALL, this partner gene is one of the AF4 family (AFF) of transcription factors. The newest AFF member to be discovered and cloned is AFF-4/AF5q31/MCEF. MCEF interacts with a transcription factor necessary for transcription of HIV-1. In addition, evidence suggests that male knockout mice are azoospermic. Therefore, the characterization of MCEF is clinically and theoretically important. The purpose of my research was to further characterize MCEF. In this paper, I first review the AFF members, focusing on MCEF. I then show a series of experimental results addressing MCEF isoforms and HIV-1 repression domains, as well as the generation of anti-MCEF antisera. Finally, I highlight intriguing results with live virus replication assays that suggest how MCEF could be exploited as a therapeutic target for AIDS.

Characterization of pituitary adenomas by immunohistochemistry of pituitary-specific transcription factors and their correlation with hormonal subtypes

2020 ◽  
Author(s):  
Araceli García-Martínez ◽  
Sandra Silva-Ortega ◽  
Beatriz López-Muñoz ◽  
Óscar Moreno-Pérez ◽  
Irene Monjas ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Pituitary Adenomas
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