Intracellular Cysteines of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulate Channel Gating

Christian Ketchum; Hongwen Yue; Karen Alessi; Shreenivas Devidas; William Guggino; Peter Maloney

doi:10.1159/000047821

Intracellular Cysteines of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulate Channel Gating

Cellular Physiology and Biochemistry ◽

10.1159/000047821 ◽

2002 ◽

Vol 12 (1) ◽

pp. 1-008 ◽

Cited By ~ 6

Author(s):

Christian Ketchum ◽

Hongwen Yue ◽

Karen Alessi ◽

Shreenivas Devidas ◽

William Guggino ◽

...

Keyword(s):

Cystic Fibrosis ◽

Channel Gating ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane

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Conformational Changes in a Pore-lining Helix Coupled to Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating

Journal of Biological Chemistry ◽

10.1074/jbc.m702235200 ◽

2007 ◽

Vol 283 (8) ◽

pp. 4957-4966 ◽

Cited By ~ 36

Author(s):

Edward J. Beck ◽

Yu Yang ◽

Sirin Yaemsiri ◽

Viswanathan Raghuram

Keyword(s):

Cystic Fibrosis ◽

Conformational Changes ◽

Channel Gating ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane ◽

Pore Lining

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Antihypertensive 1,4-Dihydropyridines as Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating Defect Caused by Cystic Fibrosis Mutations

Molecular Pharmacology ◽

10.1124/mol.105.015149 ◽

2005 ◽

Vol 68 (6) ◽

pp. 1736-1746 ◽

Cited By ~ 40

Author(s):

Nicoletta Pedemonte ◽

Tullia Diena ◽

Emanuela Caci ◽

Erika Nieddu ◽

Mauro Mazzei ◽

...

Keyword(s):

Cystic Fibrosis ◽

Channel Gating ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane

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Redox Reagents and Divalent Cations Alter the Kinetics of Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating

Journal of Biological Chemistry ◽

10.1074/jbc.274.39.27536 ◽

1999 ◽

Vol 274 (39) ◽

pp. 27536-27544 ◽

Cited By ~ 33

Author(s):

Melissa A. Harrington ◽

Kevin L. Gunderson ◽

Ron R. Kopito

Keyword(s):

Cystic Fibrosis ◽

Divalent Cations ◽

Channel Gating ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane ◽

Kinetics Of

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Phenylglycine and Sulfonamide Correctors of Defective ΔF508 and G551D Cystic Fibrosis Transmembrane Conductance Regulator Chloride-Channel Gating

Molecular Pharmacology ◽

10.1124/mol.105.010959 ◽

2005 ◽

Vol 67 (5) ◽

pp. 1797-1807 ◽

Cited By ~ 113

Author(s):

Nicoletta Pedemonte ◽

N. D. Sonawane ◽

Alessandro Taddei ◽

Jie Hu ◽

Olga Zegarra-Moran ◽

...

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Channel Gating ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane

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Faculty Opinions recommendation of Antihypertensive 1,4-dihydropyridines as correctors of the cystic fibrosis transmembrane conductance regulator channel gating defect caused by cystic fibrosis mutations.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1030591.358702 ◽

2006 ◽

Author(s):

Charles Coutelle

Keyword(s):

Cystic Fibrosis ◽

Channel Gating ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane

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Sulfamoyl-4-oxoquinoline-3-carboxamides: Novel potentiators of defective ΔF508-cystic fibrosis transmembrane conductance regulator chloride channel gating

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.10.050 ◽

2006 ◽

Vol 16 (3) ◽

pp. 537-540 ◽

Cited By ~ 25

Author(s):

Yat Fan Suen ◽

Lori Robins ◽

Baoxue Yang ◽

A.S. Verkman ◽

Michael H. Nantz ◽

...

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Channel Gating ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane

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Sulfamoyl-4-oxoquinoline-3-carboxamides: Novel Potentiators of Defective ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Gating.

ChemInform ◽

10.1002/chin.200618136 ◽

2006 ◽

Vol 37 (18) ◽

Author(s):

Yat Fan Suen ◽

Lori Robins ◽

Baoxue Yang ◽

A. S. Verkman ◽

Michael H. Nantz ◽

...

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Channel Gating ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane

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Cysteine Substitutions Reveal Dual Functions of the Amino-terminal Tail in Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating

Journal of Biological Chemistry ◽

10.1074/jbc.m105079200 ◽

2001 ◽

Vol 276 (38) ◽

pp. 35660-35668 ◽

Cited By ~ 9

Author(s):

Jian Fu ◽

Kevin L. Kirk

Keyword(s):

Cystic Fibrosis ◽

Channel Gating ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Amino Terminal ◽

Cystic Fibrosis Transmembrane ◽

Dual Functions

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The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating

The Journal of Physiology ◽

10.1113/jphysiol.2005.099457 ◽

2006 ◽

Vol 572 (2) ◽

pp. 347-358 ◽

Cited By ~ 50

Author(s):

Liying Cui ◽

Luba Aleksandrov ◽

Yue-Xian Hou ◽

Martina Gentzsch ◽

Jey-Hsin Chen ◽

...

Keyword(s):

Cystic Fibrosis ◽

Ion Channel ◽

Channel Gating ◽

Side Chain ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Ion Channel Gating ◽

Cystic Fibrosis Transmembrane

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Regulation of Channel Gating by AMP-activated Protein Kinase Modulates Cystic Fibrosis Transmembrane Conductance Regulator Activity in Lung Submucosal Cells

Journal of Biological Chemistry ◽

10.1074/jbc.m210621200 ◽

2002 ◽

Vol 278 (2) ◽

pp. 998-1004 ◽

Cited By ~ 82

Author(s):

Kenneth R. Hallows ◽

Jill E. McCane ◽

Bruce E. Kemp ◽

Lee A. Witters ◽

J. Kevin Foskett

Keyword(s):

Cystic Fibrosis ◽

Protein Kinase ◽

Channel Gating ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Amp Activated Protein Kinase ◽

Cystic Fibrosis Transmembrane

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