Ibuprofen Affects Pro- and Anti-Inflammatory Cytokine Production by Mononuclear Cells of Preterm Newborns

Neonatology ◽  
2001 ◽  
Vol 79 (2) ◽  
pp. 103-108 ◽  
Author(s):  
L. Sirota ◽  
D. Shacham ◽  
I. Punsky ◽  
H. Bessler
Keyword(s):  
Inflammatory Cytokine ◽  
Mononuclear Cells ◽  
Cytokine Production ◽  
Inflammatory Cytokine Production ◽  
Anti Inflammatory ◽  
Preterm Newborns ◽  
Anti Inflammatory Cytokine

scholarly journals TLR Costimulation Causes Oxidative Stress with Unbalance of Proinflammatory and Anti-Inflammatory Cytokine Production

2014 ◽  
Vol 192 (11) ◽  
pp. 5373-5381 ◽  
Author(s):  
Rosa Lavieri ◽  
Patrizia Piccioli ◽  
Sonia Carta ◽  
Laura Delfino ◽  
Patrizia Castellani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Inflammatory Cytokine Production ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

Modulation of pro- and anti-inflammatory cytokine production in very preterm infants

Cytokine ◽  
2003 ◽  
Vol 21 (4) ◽  
pp. 200-206 ◽  
Author(s):  
Joerg Dembinski ◽  
Daniela Behrendt ◽  
Rainer Martini ◽  
A Heep ◽  
Peter Bartmann
Keyword(s):  
Preterm Infants ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Inflammatory Cytokine Production ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

scholarly journals Downregulation of Inflammatory Cytokine Release from IL-1β and LPS-Stimulated PBMC Orchestrated by ST2825, a MyD88 Dimerisation Inhibitor

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4322
Author(s):  
Sergio Ramírez-Pérez ◽  
Luis Alexis Hernández-Palma ◽  
Edith Oregon-Romero ◽  
Brian Uriel Anaya-Macías ◽  
Samuel García-Arellano ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Inflammatory Cytokine ◽  
Mononuclear Cells ◽  
Cytokine Production ◽  
Primary Response ◽  
Peripheral Blood Mononuclear ◽  
Inflammatory Cytokine Production ◽  
Ifn Γ ◽  
Anti Inflammatory ◽  
Pathway Inhibition

The inflammatory process implicates homeostasis disruption and increased production of inflammatory mediators. Myeloid differentiation primary response 88 (MyD88) is an essential protein recruited after lipopolysaccharide (LPS) and interleukin (IL)-1β stimulation, a process that converges in nuclear factor kappa B (NF-κB) activation, as well as a transcription of several genes of both pro- and anti-inflammatory cytokines. The inhibition of MyD88 has shown efficacy by decrease inflammatory response, and has demonstrated potential application as a therapeutic target in chronic diseases. In this study, we investigate the effect of MyD88 dimerisation inhibitor ST2825 on cytokine production from rhIL-1β and LPS-stimulated peripheral blood mononuclear cells (PBMC) from healthy blood donors (HBD). ST2825 significantly downregulates the production of IFN-γ, IL-6, IL-12, IL-2, IL-15, IL-7, VEGF, IL-1Ra, IL-4, IL-5, IL-13 and IL-9 (p < 0.05) in LPS-stimulated PBMC. Moreover, ST2825 had a relatively low impact on IL-1β signalling pathway inhibition, showing that only a few specific cytokines, such as IFN-γ and IL-1Ra, are inhibited in rhIL-1β-stimulated PBMC (p < 0.01). In conclusion, MyD88 dimerisation inhibitor ST2825 showed high efficacy by inhibiting pro- and anti-inflammatory cytokine production in LPS-stimulated PBMC. Moreover, although rhIL-1β induced a sustained cytokine production (p < 0.05), ST2825 did not show a significant effect in the secretion of neither pro- nor anti-inflammatory cytokines in rhIL-1β-stimulated PBMC.

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